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ลำดับ ชื่อบทความ ชื่อบทความภาษาอังกฤษ บทคัดย่อ ผู้ตีพิมพ์ กลุ่ม/รูปแบบการนำเสนอ ระดับ รายละเอียด
1 Synthesis and cytotoxic activity of azanaphoquinone annelated pyrrole derivatives Synthesis and Cytotoxic Activity of Azanaphthoquinone Annelated Pyrrole Derivatives

Azanaphthoquinone annelated pyrroles have been developed from the natural anticancer drug, mitoxantrone to reduce cardiotoxic side-effects. This paper reports the synthesis of azanaphthoquinone annelated pyrrole derivatives as cytostatic compounds. The synthetic pathway was started from the commercially-available 5-hydroxyisoquinoline via a three step reaction to obtain 1H-pyrrolo[3,2-g]isoquinoline-4,9-dione. N-Alkylation of nitrogen atom in pyrrole ring was carried out under basic conditions with different side chains to obtain mono-substituted azanaphthoquinone annelated pyrroles (2a-e) with 2 to 3-carbon side chains in moderate to good yields. The hydrazone and thiosemicarbazone derivatives were synthesized by a condensation reaction of mono-substituted products 2 with hydrazine and thiosemicarbazide respectively. The reactions occurred regio-selectively at C-4 to give hydrazones (3a-e) and thiosemicarbazones (4a-e) respectively. The synthesized compounds were purified by column chromatography and characterized by spectroscopic techniques, including 1H NMR, 13C NMR, IR, UV and LC-MS. The antiproliferative activity of the synthesized compounds was evaluated on cervical carcinoma: KB/HeLa by using xCELLigence from Roche. The results showed that the mono-substituted products with 2-carbon side chain (2b) exhibited the highest activity with IC50 value of 0.008 M. The mono-substituted product 2 showed higher inhibition in comparison to hydrazone and thiosemicarbazone derivatives. These results lead to the optimization of the target molecules in further works. 

นิภาวรรณ พองพรหม TCI กลุ่ม 2 ชาติ
    วันที่ตีพิมพ์
  • 2017-09-01
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  • วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยอุบลราชธานี
    DOI
2 ชุดการทดลองเคมีแบบย่อส่วนต้นทุนต่ำเพื่อสนับสนุนความเข้าใจมโนมติ เรื่อง สมดุลเคมี สำหรับนักเรียนระดับมัธยมศึกษาปีที่ 5 0

The main purpose of this research was to develop low-cost small-scale chemistry experimental kit on chemical equilibrium, and then investigate students’ conceptual understanding from learning with the developed kit. The samples were 37 of 11-grade students studying in a large-size high school in Ubon Ratchathani. The data collecting tools included a two-tier diagnostic test and a survey of students’ attitudes and experiences towards chemistry subject. The implementation of the small-scale experimental kit through 5E-inquiry cycle resulted that students’ averaged percentages for each of the pretest, posttest and retentiontest were 20.48,60.64and59.60, respectively, in which the normalized gain was in the medium level. The dependent samples t-test analysis indicated that their posttest scores were statistically higher than those of pretest scores, but not statistically different from the retention-test scores at the 95% significance level. After the intervention, the total percentage of students in the partial and sound conceptual understanding (PU+SU) categories was increased by 51.48, while the total percentage of students in the mis- and no-conceptual understanding (MU+NU) decreased by51.89. In addition, theirpost-attitudes and experiences towards chemistry subject were statistically higher than those before learning using the kit. This verified that the intervention of low-cost small-scale chemistry experimental kit was the effective tool for promoting students to change to the more correct conceptual understanding and to the more positive attitudes and experiences towards chemistry.

ศักดิ์ศรี สุภาษร TCI กลุ่ม 1 ชาติ
    วันที่ตีพิมพ์
  • 2017-07-01
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  • วารสารหน่วยวิจัยวิทยาศาสตร์ เทคโนโลยี และสิ่งแวดล้อมเพื่อการเรียนรู้
    DOI
3 การสร้างเซลล์กัลวานิกอย่างง่ายที่ทําจากเส้นด้ายเพื่อศึกษาไฟฟ้าเคมี Fabricationof Simple Galvanic Cells Using Cotton Thread to Investigate Electrochemistry

The main purpose of this research article was to fabricate simple galvanic cellsusing cotton thread. This device contains various metal strips (Cu, Ag, Zn, Pb, Sn, Fe, Al and Mg), metal solutions, and potassium nitrate solution serving as electrodes, metal ions, and electrolyte, respectively. In this article, cotton thread is not only used to be a support for reactions between each half-cell, but also a salt bridge for electrolyte. The results showed that the observed cell potentials, Ecell (Obsd) were slightly different from the theoretical cell potentials, Ecell (Theor), calculated from the Nernst equation. This device also can be used to investigate the effect of concentrations on the electromotive force (emf). This device can be applied as a teaching tool of electrochemistry for students at the secondary school level because of an easy way to fabricate galvanic cells.

เสนอ ชัยรัมย์ TCI กลุ่ม 1 ชาติ
    วันที่ตีพิมพ์
  • 2017-07-01
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  • วารสารหน่วยวิจัยวิทยาศาสตร์ เทคโนโลยี และสิ่งแวดล้อมเพื่อการเรียนรู้
    DOI
4 การใช้กระติกน้ำสุญญากาศเป็นแคลอริมิเตอร์อย่างง่าย เพื่อหามวลโมเลกุลของสารประกอบจากสมบัติคอลลิเกตีฟ Using vacuum flask as a simple calorimeter for determination of molecular weight of compounds from colligative properties

This research aimed to develop an experimental demonstration in the laboratory to determine the molecular weight of compound from freezing point depression by using a vacuum flask as a simple calorimeter. Colligative properties depend on the number, not the identity of molecule be measuring. All the substances used in this study were environmental-friendly: water was used as a solvent, while allsolutes were rock salt, monosodium glutamate and sugar. In experiment, the solvent or solution was placed in a vial with a thermometer, put into a vacuum flask containing sprinkle rock salt on the ice, and then record the decreasing temperature every minute. The relationship between the temperature and time was plotted to determine the freezing point of the solvent (T) or solution (Tf ). Furthermore, this approach was applied to determine the molecular weight of compound  in red or yellow food color. The calculated molecular weight of all solutes was closed to the actual value. The percentage error of rock salt, monosodium glutamate, sugar, red food colour and yellow food colour was 0.53%, 1.12%, 1.86%, 0.31%, and 0.11% respectively. This experimental demonstration ought to be interesting to science teachers for the instruction of colligative properties at all levels in laboratory.             

เสนอ ชัยรัมย์ TCI กลุ่ม 2 ชาติ
    วันที่ตีพิมพ์
  • 2017-05-01
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  • วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยอุบลราชธานี
    DOI
5 Development of corn waste for reuse as a catalyst สายสมร ลำลอง TCI กลุ่ม 1 ชาติ
    วันที่ตีพิมพ์
  • 2018-12-07
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  • Global Society For Research And Development international conference
    DOI
6 ผลการจัดการเรียนรู้สะเต็มศึกษาของนักเรียนชั้นมัธยมศึกษาปีที่ 6 เรื่องไฟฟ้าเคมี กานต์ตะรัตน์ วุฒิเสลา TCI กลุ่ม 1 ชาติ
    วันที่ตีพิมพ์
  • 2018-12-06
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  • การประชุมวิชาการระดับชาติ ครั้งที่ 15 มหาวิทยาลัยเกษตรศาสตร์วิทยาเขต กำแพงแสน
    DOI
7 Ready-to-Use Titanium Dioxide Slurry for Cosmetics Application Ready-to-Use Titanium Dioxide Slurry for Cosmetics Application

The objective of research was to prepare ready-to-use TiO2 in slurry form for easy use in cosmetics. Three types of TiO2 source were prepared as TiO2 slurry, namely commercial TiO2 (TiO2 -A and TiO2 -P25) and synthesized TiO2 (TiO2 -S) The suitable of solvents and amount of TiO2 , including optimum sonication time were studied. The experiments were set up as two groups of solvent, i.e. (1) six types of pure solvent and (2) nine types of mixed solvent. In order to achieve the best result of using solvent, 0.0075 g TiO2 powder was added to each of 15 mL solvent and sonicated for 10 minutes. The results showed that butylene glycol (BG) was the best of pure solvent, and mixture of propylene glycol (PG) and BG ratio 1:1 was the best of mixed solvent. Due to lower cost of PG than BG, PG mixed with BG was chose as the solvent for slurry preparation. The amount of TiO2was varied from 10-60% w/v of BG. Best slurry texture obtained using 60 %w/v of TiO2 . The study of sonication time was varied from 10-60 minutes. It was found that the optimum time was at 30 minutes. Texture and stability of prepared slurry were similar to commercial. Different sunscreen were formulated by containing prepared and commercial slurry separately and evaluated. There were no significant difference results between prepared slurry and commercial. In order to investigate the satisfaction of products, 40 volunteers were asked to use products for one week and answer in the questionnaires. The product containing prepared slurry was satisfied by 96% of volunteers, whereas the product containing commercial slurry was satisfied by 76% of volunteers. 

นุชนาพร พิจารณ์ TCI กลุ่ม 1 ชาติ
    วันที่ตีพิมพ์
  • 2019-01-01
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  • The Journal of Industrial Technology Suan Sunandha Rajabhat University
    DOI
8 ไบโอซาร์ (วัสดุมหัศจรรย์) : การสังเคราะห์ พิสูจน์เอกลักษณ์ และศักยภาพการประยุกต์ใช้งาน Biochar (Magical Material) : Synthesis, Characterization and Potential Applications

ไบโอชาร์ที่ผลิตจากสารชีวมวลเป็นไบโอชาร์ที่อุดมไปด้วยคาร์บอน การผลิตไบโอชาร์จากสารชีวมวลอาศัยกระบวนการไพโรไลซิสซึ่งเป็นกระบวนการเผาไหม้ด้วยความร้อนโดยไม่ใช้ออกซิเจนหรือในสภาวะจํากัดออกซิเจนไบโอชาร์มักถูกใช้เพื่อลดปัญหาสิ่งแวดล้อมด้านต่าง ๆ เช่น ช่วยลดปริมาณแก๊สคาร์บอนไดออกไซด์ในชั้นบรรยากาศได้โดยกักเก็บคาร์บอนในดิน และใช้เพื่อปรับปรุงดินสําหรับทําการเกษตรเนื่องจากถ่านคาร์บอนมีพื้นที่ผิวสูงและมีปริมาณรูพรุนสูง จึงสามารถช่วยกักเก็บน้ําและธาตุอาหารในดินให้กับพืชได้เป็นอย่างดี นอกจากนี้ไบโอชาร์ยังสามารถแก้ปัญหามลภาวะทางน้ําได้ด้วย โดยการดูดซับสารหรือโลหะหนักเอาไว้ในโครงสร้างและรูพรุนของไบโอชาร์ เนื่องจากไบโอชาร์มีประโยชน์ใช้งานที่หลากหลายและมีต้นทุนในการผลิตต่ํา จึงทําให้ไบโอชาร์เป็นวัสดุที่น่าสนใจในการนําไปศึกษาวิจัยต่อยอดเพื่อพัฒนาเป็นผลิตภัณฑ์ที่สามารถนําไปประยุกต์ใช้ในด้านอื่น ๆ ได้อีกมากมาย บทความนี้นําเสนอวิธีการเตรียม การพิสูจน์เอกลักษณ์ และการประยุกต์ใช้ไบโอชาร์ทั้งในปัจจุบันและในอนาคต

สายันต์ แสงสุวรรณ TCI กลุ่ม 1 ชาติ
    วันที่ตีพิมพ์
  • 2023-01-01
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  • วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยอุบลราชธานี
    DOI
9 การสังเคราะห์และปรับปรุงคุณสมบัติของโคบอลต์ซิงค์อะลูมิเนียมเลเยอร์ดับเบิลไฮดรอกไซด์ด้วยอนุภาคแม่เหล็กระดับนาโนและไคโตซานสำหรับการดูดซับสีย้อมบริลเลียน กรีน Synthesis and Modification of CoZnAl Layered Double Hydroxides with Magnetic Nanoparticle and Chitosan for Brilliant Green Dye Adsorption

Cobalt-zinc-aluminum layered double hydroxides (CoZnAl-LDHs) have been prepared and successfully modified with magnetic nanoparticles and chitosan (Fe3O4CS@CoZnAl-LDHs) for being used as Brilliant Green (BG) dye adsorbent to solve the dye contamination in water problem. Magnetic nanoparticles (Fe3O4) allow easy separation of the adsorbent from the solution, and chitosan (CS) will increase the hydroxyl group density for the interaction with the positively charged BG dye. The materials were characterized by XRD and it revealed that the modified materials exhibited the structural characteristics of LDHs. From dye adsorption studies at pH 7 and 25 ?C with initial dye concentration of 20 ppm, Fe3O4CS@CoZnAl-LDHs exhibited 99% dye removal, which was greater than that of CoZnAl-LDHs (58%). The adsorption process reached equilibrium within 360 min. In addition, the adsorption isotherm followed the Langmuir model, and from the kinetic studies, this adsorption process corresponded to a pseudo second-order reaction. The synthesized material is promising for being used as an adsorbent to remove the dye from polluted water.

สุภาพ ตาเมือง TCI กลุ่ม 2 ชาติ
    วันที่ตีพิมพ์
  • 2023-07-01
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  • วารสารวารสารวิทยาศาสตร์และวิทยาศาสตร์ศึกษา
10 การศึกษาสมรรถนะการแก้ปัญหาแบบร่วมมือของนักเรียนชั้นมัธยมศึกษาปีที่ 4 เรื่อง สารละลาย โดยใช้การจัดการเรียนรู้สืบเสาะร่วมกับชุดการทดลองสะตีมศึกษา The Study of the Collaborative Problem-Solving Competency of Grade-10 Students on Solution using Inquiry-based learning with a set of STEAM Education Experiments

งานวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาสมรรถนะการแก้ปัญหาแบบร่วมมือ เรื่อง สารละลาย ของนักเรียนชั้นมัธยมศึกษาปีที่ 4 ด้วยการจัดการเรียนรู้สืบเสาะร่วมกับชุดการทดลองสะตีมศึกษา แบบแผนการวิจัยเป็นแบบกลุ่มตัวอย่างเดียวและประเมินระหว่างเรียนครั้งเดียว กลุ่มตัวอย่างจำนวน 40 คนได้จากการเลือกแบบเจาะจง เครื่องมือที่ใช้ในการวิจัยคือ แผนการจัดการเรียนรู้สืบเสาะร่วมกับชุดการทดลองสะตีมศึกษา จำนวน 5 แผน และแบบประเมินสมรรถนะการแก้ปัญหาแบบร่วมมือ แผนการจัดการเรียนรู้สืบเสาะ นักเรียนทดลองเตรียมสารละลาย 2 M CuSO4 จาก CuSO4.5H2O  นักเรียนทดลองเจือจางสารละลาย 2 M เป็น 1 M CuSO4 นักเรียนผสมสารละลาย 1 M และ 2 M CuSO4 ได้ความเข้มข้นของสารละลายผสม 1.5 M CuSO4 แผนการจัดการเรียนรู้สะตีมศึกษาจะอยู่ภายใต้หัวข้อเรื่อง สารละลาย ได้แก่ สบู่เหลวกลิ่นธรรมชาติ สบู่ก้อนหอมสดชื่น น้ำยาล้างจานสมุนไพร ยาหม่องน้ำ และสเลอปี้หรรษา โดยใช้เวลาในการจัดการเรียนรู้ 10 ชั่วโมง จากการวิเคราะห์สมรรถนะการแก้ปัญหาแบบร่วมมือจากใบงานสะตีมศึกษาด้วยการวิเคราะห์เนื้อหาเพื่อตีความคำตอบของนักเรียนและสรุปข้อมูลและและจัดระดับสมรรถนะของนักเรียนตามกรอบการประเมินสมรรถนะการแก้ปัญหาแบบร่วมมือของ PISA พบว่าสมรรถนะการแก้ปัญหาแบบร่วมมือเฉลี่ยทุกด้านมีคะแนนอยู่ที่ 2.73 คะแนน คิดเป็นร้อยละ 91 ซึ่งอยู่ในระดับสมรรถนะสูง

กานต์ตะรัตน์ วุฒิเสลา TCI กลุ่ม 2 ชาติ
    วันที่ตีพิมพ์
  • 2024-01-01
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  • วารสารวิทยาศาสตร์และวิทยาศาสตร์ศึกษา
11 ไฮโดรเจลพอลิเมอร์ผสม(2-อะคริลามิโด-2-เมทิลโพรเพนซัลโฟนิค เอซิด-อะคลิลิค เอซิด) รองรับอนุภาคคอปเปอร์ระดับนาโนและการใช้ประโยชน์เป็นตัวเร่งปฏิกิริยาสำหรับการผลิตแก๊สไฮโดรเจนจากปฏิกิริยาการย่อยสลายน้ำด้วยโซเดียมโบโรไฮไดรด์ Hydrogel poly(2-acrylmido-2-methylpropanesulfonic acid-co-acrylic acid) supported copper nanoparticles and their use as catalyst for hydrogen production from hydrolysis of sodium borohydride

ในงานวิจัยนี้ ไฮโดรเจลพอลิเมอร์ผสมที่มาจาก 2-อะคริลามิโด-2-เมทิลโพรเพนซัลโฟนิค เอซิด กับ อะคลิลิค เอซิด ด้วยอัตราส่วนต่าง ๆ สามารถสังเคราะห์ขึ้นได้โดยอาศัยปฏิกิริยาฟรีแรดิคอลพอลิเมอไรเซชันเพื่อใช้ในการดูดซับไอออนคอปเปอร์ด้วยหมู่ฟังก์ชันที่มีอยู่ภายในโครงร่างข่ายไฮโดรเจล หลังจากนั้น ไอออนคอปเปอร์ที่ถูกตรึงภายในโครงสร้างไฮโดรเจลถูกเปลี่ยนให้เป็นอนุภาคคอปเปอร์ระดับนาโนโดยอาศัยปฏิกิริยารีดักชันจากการใช้โซเดียมโบโรไฮไดรด์ทำหน้าที่เป็นตัวรีดิวซ์  ศึกษาการบวมตัวของไฮโดรเจล ตลอดจนวิเคราะห์อนุภาคคอปเปอร์ระดับนาโนในไฮโดรเจลพอลิเมอร์โดยอาศัยเทคนิคฟูเรียร์ทรานส์ฟอร์มอินฟราเรดสเปกโตรสโคปีและการเปลี่ยนแปลงน้ำหนักของสารโดยอาศัยคุณสมบัติทางความร้อน หลังจากนั้น ศึกษาประสิทธิภาพในการเร่งปฏิกิริยาของไฮโดรเจลพอลิเมอร์ผสมที่รองรับอนุภาคคอปเปอร์ระดับนาโนในการย่อยสลายน้ำด้วยโซเดียมโบโรไฮไดรด์สำหรับการผลิตแก๊สไฮโดรเจน คำนวณพารามิเตอร์จำเพาะของปฏิกิริยาจากสมการอาร์รีเนียสและสมการอายริงก์ ผลการคำนวณที่ได้พบว่า พลังงานก่อกัมมันต์ (Ea) มีค่า 18.20 kJ mol-1 ในขณะที่เอนทาลปีพลังงานกระตุ้นและเอนโทรปีพลังงานกระตุ้นมีค่า 20.84 kJ mol-1 และ -197.54 kJ mol-1 K-1 ตามลำดับ นอกจากนี้ ไฮโดรเจลพอลิเมอร์ผสมที่รองรับอนุภาคคอปเปอร์ระดับนาโนยังสามารถนำกลับมาใช้ใหม่ได้หลายครั้งโดยยังคงประสิทธิภาพในการเร่งปฏิกิริยา งานวิจัยนี้แสดงให้เห็นว่า ไฮโดรเจลพอลิเมอร์ผสมที่รองรับอนุภาคคอปเปอร์ระดับนาโนมีประโยชน์อย่างมากในการย่อยสลายน้ำด้วยโซเดียมโบโรไฮไดรด์สำหรับการผลิตแก๊สไฮโดรเจน รวมทั้งในการเร่งปฏิกิริยาอื่น ๆ ที่น่าสนใจ

เสนอ ชัยรัมย์ TCI กลุ่ม 2 ชาติ
    วันที่ตีพิมพ์
  • 2024-01-01
    ชื่อวารสาร
  • วารสารวิทยาศาสตร์และวิทยาศาสตร์ศึกษา (JSSE)


ระดับนานาชาติ 6qwCQR.png
ลำดับ ชื่อบทความ ชื่อบทความภาษาอังกฤษ บทคัดย่อ ผู้ตีพิมพ์ กลุ่ม/รูปแบบการนำเสนอ ระดับ รายละเอียด
1 A DFT study of volatile organic compounds adsorption on transition metal deposited graphene A DFT study of volatile organic compounds adsorption on transition metal deposited graphene

Recently, elevated global emission of volatile organic compounds (VOCs) was associated to the acceleration and increasing severity of climate change worldwide. In this work, we investigated the performance of VOCs removal via modified carbon-based adsorbent using density functional theory. Here, four transition metals (TMs) including Pd, Pt, Ag, and Au were deposited onto single-vacancy defective graphene (SDG) surface to increase the adsorption efficiency. Five prototypical VOCs including benzene, furan, pyrrole, pyridine, and thiophene were used to study the adsorption capability of metal-deposited graphene adsorbent. Calculation results revealed that Pd, Pt, Au, and Ag atoms and nanoclusters bind strongly onto
the SDG surface. In this study, benzene, furan and pyrrole bind in the
-interaction mode using delocalized -electron in aromatic ring, while pyridine and thiophene favor X- interaction mode, donating
lone pair electron from heteroatom. In terms of adsorption, pyridine VOC adsorption strengths to the TM-cluster doped SDG surfaces are Pt
4 (-2.11 eV) > Pd4 (-2.05 eV) > Ag4 (-1.53 eV) > Au4 (-1.87 eV). Our findings indicate that TM-doped SDG is a suitable adsorbent material for VOC removal. In addition, partial density of states analysis suggests that benzene, furan, and pyrrole interactions with TM cluster are based on p-orbitals of carbon atoms, while pyridine and thiophene interactions are facilitated by hybridized sp2-orbitals of heteroatoms. This work provides a key insight into the fundamentals of VOCs adsorption on carbon-based adsorbent.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2016-02-28
    ชื่อวารสาร
  • Applied Surface Science
    DOI
2 Preparation and characterization of modified telechelic natural rubber-based pressure-sensitive adhesive ศิริวัฒน์ ระดาบุตร Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-12-31
    ชื่อวารสาร
  • JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
    DOI
3 Photoresponsive Nano-Coumarin with Indole Auxin Hormone รักเกียรติ จิตคติ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-11-30
    ชื่อวารสาร
  • Defect and Diffusion Forum
    DOI
4 Non-Enzymatic Glucose Sensors for Sensitive Amperometric Detection Based on Simple Method of Nickel Nanoparticles Decorated on Magnetite Carbon Nanotubes Modified Glassy Carbon Electrode มะลิวรรณ อมตธงไชย Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-11-30
    ชื่อวารสาร
  • International Journal of Electrochemical Science
    DOI
5 Synthesis and properties biodegradable hydrogels based on cross-linked natural rubber and cassava starch ชัยวุฒิ วัดจัง Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-11-01
    ชื่อวารสาร
  • Journal of Elastomers and Plastics
    DOI
6 Push-Pull N-Annulated Perylene-Based Sensitizers for Dye-Sensitized Solar Cells: Theoretical Property Tuning by DFT/TDDFT Push-Pull N-Annulated Perylene-Based Sensitizers for Dye-Sensitized Solar Cells: Theoretical Property Tuning by DFT/TDDFT

We evaluate the effects of donor and p-linker moieties on power-conversion efficiency for a series of push-pull type, Nannulated perylene dyes for dye-sensitized solar cells. Triphenylamine and diphenylamine are used as electron donors. We investigate the structural, optical, and electronic properties of dyes by performing density functional theory (DFT) calculations at the B3LYP level, using the 6-311G(d,p) basis set. Electronic absorption wavelengths were investigated using time dependent DFT (TD-DFT) calculations on M062x/6-311G(d,p) in THF. Our calculated results reveal that the diphenylamine (DPA) donor provides a small dihedral angle between diphenylamine and the perylene core, resulting in a red-shifted absorption spectrum. Introduction of an O-methoxy substituent into diphenylamine improves its donor properties, red-shifts the absorption wavelength, and increases the dipole moment, indicating increased intramolecular charge transfer in the Omethoxy substituted dye. Incorporation of a C-C triple bond in linker extends the p-conjugation system and decreases the dihedral angle between N-annulated perylene and cyanoacrylic acid; the dye adopts a planar structure, causing a red-shift in the absorption spectrum. Our results demonstrate that use of computational design can to help the experimentalist for out looking future developments to identify push-pull perylene sensitizers for highly efficient solar cells.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-10-25
    ชื่อวารสาร
  • CHEMISTRYSELECT
    DOI
7 Gold nanoparticles stabilized by starch polymer and their use as catalyst in homocoupling of phenylboronic acid Gold nanoparticles stabilized by starch polymer and their use as catalyst in homocoupling of phenylboronic acid

In this study, gold nanoparticles (Au NPs) stabilized by a starch polymer have been successfully prepared and characterized via a number of techniques including X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), UV-visible spectroscopy (UV-vis), transmission electron microscopy (TEM), and dynamic light scattering (DLS) measurements. The catalytic activity of starch-stabilized Au NPs was also examined toward the homocoupling of phenylboronic acid in water using oxygen in air as oxidant at an ambient temperature (25 ± 1 °C). Several parameters including the catalyst loading, base equivalent (eq.), base type, and reaction time were studied. This study offers a simple, inexpensive and environmentally friendly procedure for the stabilization of colloidal gold catalysts using a hydroxyl-rich structure of starch polymer with a great promise through potential applications in related fields.

เสนอ ชัยรัมย์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-10-01
    ชื่อวารสาร
  • 0
8 Starch-supported gold nanoparticles and their use in 4-nitrophenol reduction Starch-supported gold nanoparticles and their use in 4-nitrophenol reduction

Gold nanoparticles (AuNPs) have been synthesized through a green synthesis method using mung bean starch (MBS) as both reducing and stabilizing agents. The chemical state was analyzed by X-ray photoelectron spectroscopy (XPS). The crystalline structures were characterized by X-ray diffraction (XRD). The thermal properties were measured by thermogravimetric analysis and differential thermal analysis (TGA/DTA). The surface morphology was investigated by scanning electron microscopy (SEM). In order to investigate the catalytic activity, the mung bean starch-supported AuNPs (MBS-AuNPs) was utilized as a heterogeneous catalyst in the reduction of 4-nitrophenol (4-NP) in the presence of sodium borohydride (NaBH4). The kinetic studies under the different experimental conditions were performed in order to determine the activation parameters from the Arrhenius and Eyring equations. It was found that the activation energy (Ea), activation enthalpy (DH# ) and activation entropy (DS# ) were calculated to be 47.42 kJ mol1 , 44.78 kJ mol1 and 261.49 kJ mol1 , respectively. In addition, the catalytic activity was 73% reduction after recycling at the end of the fifth use. This work offers a non-toxic procedure for the synthesis of nanoparticles using starch-rich polymers with a great promise toward other potential applications.

เสนอ ชัยรัมย์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-09-30
    ชื่อวารสาร
  • Journal of Saudi Chemical Society
    DOI
9 Influence of Pyrolytic Carbon Black Prepared from Waste Tires on Mechanical Properties of Natural Rubber Vulcanizates Influence of Pyrolytic Carbon Black Prepared from Waste Tires on Mechanical Properties of Natural Rubber Vulcanizates

This research aimed to investigate the possibility of pyrolytic carbon black (PCB) used as filler in natural rubber (NR) and its effect on Mooney viscosity, cure characteristics and mechanical properties compared with commercial carbon black (N774). The results revealed that Mooney viscosity, stiffness and heat build-up tended to increase with increasing both PCB and N774 loading, whereas elongation at break decreased. However, the maximum tensile and tear strengths appeared at the optimum filler loading for both PCB and N774. At similar filler content, PCB-filled NR compounds have higher cure time, heat build-up and thermal resistance. Nevertheless, they exhibited lower Mooney viscosity and mechanical properties compared to N774-filled NR. Finally, it can be concluded that PCB could be utilized as filler in NR compound to act as semi-reinforcing filler and was classified as a filler to reduce costs.

สราวุธ ประเสริฐศรี Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-08-23
    ชื่อวารสาร
  • Key Engineering Materials
10 Significant enhancement in the performance of porphyrin for dye-sensitized solar cells: aggregation control using chenodeoxycholic acid

In this work, a series of porphyrin-based sensitizers, coded as ZnTEP, ZnTTEP, and ZnTTTD in which different kinds of thienyl groups are used as the p-linker, have been designed and successfully synthesized. Their synthesis, photophysical and electrochemical properties, and theoretical DFT calculations, as well as their applications in dye-sensitized solar cells (DSSCs) are reported. The results showed that the power conversion efficiency (Z) increases in the order of 1.14, 2.15 and 3.51% for ZnTEP, ZnTTEP and ZnTTTD, respectively. A significant improvement in the Z value was achieved with ZnTTTD-based solar cells, which was approximately three times the magnitude when compared to the lowest ZnTEP-based solar cells. Moreover, the effects of chenodeoxycholic acid (CDCA) in a dye solution as a co-adsorbent on the photovoltaic performance of DSSCs were investigated. It was found that the coadsorption of CDCA can hinder the formation of dye aggregates and the improve electron injection yield and thus Jsc. The Z value for ZnTTTD with the CDCA co-sensitizer dramatically increases up to 6.51%. This understanding of p-linker and co-sensitizer effects on the performance of porphyrins will serve as a guideline for the design of future dye sensitizers for DSSCs.

ทินกร แก้วอินทร์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2017-06-14
    ชื่อวารสาร
  • NEW JOURNAL OF CHEMISTRY
    DOI
11 A spectroscopic study of indigo dye in aqueous solution: A combined experimental and TD-DFT study

This study reports UV–Visible spectra and electronic structures of indigo (IG) in aqueous solution using a combination of experimental and theoretical methods. In the visible region, the experimental absorption spectrum of the solution showed a broad peak with the longest wavelength of maximal absorption (λmax) value at 708 nm. For the theoretical method, a trans-IG monomer and a trans-IG bound with two water molecules (IG.2W) were optimized in the ground state using the B3LYP and B3LYP-D3 calculations with the 6-31 + G(d,p) basis set and the SCRF-CPCM model for taking solvent effect into account was also applied. Sequentially, the UV–Visible spectra and λmax of the optimized trans-IG and IG.2W models in the implicit water were simulated by the time-dependent density functional theory (TD-DFT) calculations. The TD-DFT methods including BLYP, B3LYP, PBE0, CAM-B3LYP, M06-2X, ωB97XD, LC-BLYP, and LC-ωPBE functionals without and with the D3 correction and the 6-31 + G(d,p) basis set were selected. The results pointed out that BLYP and BLYP-D3 were the best methods because they could reproduce the experimental λmax value of IG in aqueous solution. The predicted λmax values of IG.2W were almost equal to 708 nm (the experimental data), indicating that IG.2W could be responsible for optical properties of IG.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-12-01
    ชื่อวารสาร
  • JOURNAL OF LUMINESCENCE
12 Development of interactive particulate-level visualization in chemistry by using augmented reality technology: Collision theory and chemical reaction rate ศักดิ์ศรี สุภาษร Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-11-18
    ชื่อวารสาร
  • Turkish Online Journal of Educational Technology
    DOI
13 Multi step energy transfer between three Si_LTL and SiGe_LTL zeoliteloaded dyes ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-10-01
    ชื่อวารสาร
  • Journal of Porous Materials
    DOI
14 Fabrication of a three-dimensional electrochemical paper-based device (3D-ePAD) for individual and simultaneous detection of ascorbic acid, dopamine and uric acid Fabrication of a three-dimensional electrochemical paper-based device (3D-ePAD) for individual and simultaneous detection of ascorbic acid, dopamine and uric acid

We report the development of a three-dimensional electrochemical paper-based analytical device (3DePAD) for the individual and simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA). The device was fabricated by alkyl ketene dimer (AKD)-inkjet printing of a circularly hydrophobic zone on filter paper for application of aqueous samples coupled with screen-printing of the electrodes on the paper which was folded underneath hydrophobic zone. A self-assembled threeelectrode system, comprising a graphite paste modified with Fe3O4@Au-Cys/PANI was fabricated on the patterned paper by screen printed through the pre-designed transparent film slit. The three electrodes of Fe3O4@Au-Cys/PANI modified graphite electrodes (Fe3O4@Au-Cys/PANI/GFE) on the layout paper were served as the working electrode, the reference electrode, and the counter electrode, respectively. Cyclic voltammetry (CV) was used to study the electrochemical mechanism of AA, DA and UA. The results indicated that a high sensitivity towards AA, DA and UA was observed. Our results suggested that coating the working electrode with anionic surfactant, SDS (1 mM, pH 2), provides the distinguishable oxidation peak potential of AA and did not overlap with the oxidation peak of DA and UA. As a result, simultaneous determination of these three molecules in a mixture can be achieved. Examples of individual quantification of DA and UA in pharmaceutical and urine samples were demonstrated using differential pulse voltammetry (DPV). Under the optimum condition, the developed 3D-ePAD gave a linearity ranged from 20 to 1,000 µM for both DA and UA. The detection limits were 2.19 and 1.80 µM for DA and UA, respectively. There are no significant matrix interferences in the analyzed samples which can be concluded that the proposed method is suitable for the quantification of DA and UA with sufficient accuracy and precision.

มะลิวรรณ อมตธงไชย Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-07-01
    ชื่อวารสาร
  • International Journal of Electrochemical Science
15 การพัฒนาความเข้าใจมโนมติของนักเรียนระดับมัธยมศึกษาปีที่ 5 เรื่อง อัตราการเกิดปฏิกิริยาเคมี ด้วยการทดลองแบบสืบเสาะ สุภาพ ตาเมือง Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-07-01
    ชื่อวารสาร
  • วารสารศึกษาศาสตร์ มหาวิทยาลัยเชียงใหม่
    DOI
16 Carbon-doped boron nitride nanosheet as a promising metal-free catalyst for NO reduction: DFT mechanistic study ศิริพร จึงสุทธิวงษ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-05-05
    ชื่อวารสาร
  • Applied Catalysis A: General
    DOI
17 Monitoring of glucose and ethanol during winefermentation by bienzymatic biosensor อัญชลี สำเภา Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-05-01
    ชื่อวารสาร
  • Journal of Electroanalytical Chemistry
    DOI
18 Selective amperometric flow-injection analysis of carbonfuran using a molecularly-imprinted polymer and gold coated magnetite modified carbon nanotube-paste electrode มะลิวรรณ อมตธงไชย Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-03-01
    ชื่อวารสาร
  • Talanta
    DOI
19 Complexometric and argentometric titrations using thread-based analytical devices ปุริม จารุจำรัส Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-17
    ชื่อวารสาร
  • Talanta
    DOI
20 Molecular docking study of pyrrolyl benzohydrazide derivatives to explore the structure requirements of InhA inhibitors พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    DOI
21 Rational design of PknB inhibitors in class of 4-oxo-crotonic acid derivatives as highly potent anti-tuberculosis agents พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    DOI
22 Computer aided molecular design of ATPase inhibitors in a series of 7-chloro-4-piperazinoquinoline derivatives: Molecular docking and 3D-QSAR study พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    DOI
23 Elucidating structural basis of 4-aminoquinoline derivatives as novel M. tuberculosis DNA GyrB inhibiters: molecular docking study พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    DOI
24 Structure based drug design of 2-(1H-benzo[d]imidazol-2-yl)-2-cyanovinyl as DNA gyrase subunit B inhibitors for anti-tuberculosis agent พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    DOI
25 carboxamide analogues as DNA gyrase subunit B inhibitors for anti-tuberculosis agents: 3D-QSAR Molecular docking calculations พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    DOI
26 Molecular modeling of InhA inhibitors in the class of Benzimidazole derivatives as a novel Anti-tuberculosis agents พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON 2018)
    DOI
27 The equilibrium study of methylene blue from aqueous solution using zeolite synthesized as highly potential adsorbent from water sludge พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    DOI
28 Utilization of zeolites synthesized from water sludge for heavy metal treatment in wastewater พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2018 (PACCON2018)
    DOI
29 A Novel Benzo[d,e]Chromene for Organic Light Emitting Diodes (OLEDs) รักเกียรติ จิตคติ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-01
    ชื่อวารสาร
  • Applied Mechanics and Materials
    DOI
30 Poly(m-ferrocenylaniline) modified carbon nanotubes-paste electrode encapsulated in nafion film for selective and sensitive determination of dopamine and uric acid in the presence of ascorbic acid เสนอ ชัยรัมย์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-01
    ชื่อวารสาร
  • Journal of Saudi Chemical Society
    DOI
31 Fabricating Simple Wax Screen-Printing Paper-Based Analytical Devices To Demonstrate the Concept of Limiting Reagent in Acid−Base Reactions เสนอ ชัยรัมย์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-02-01
    ชื่อวารสาร
  • Journal of Chemical Education
    DOI
32 Atomic force microscopy investigation of phase morphology correlated with adhesive properties for modified telechelic natural rubber based-pressure sensitive adhesive ศิริวัฒน์ ระดาบุตร Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-01-18
    ชื่อวารสาร
  • JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
    DOI
33 Use of a smartphone as a Colorimetric Analyzer in Paper-based Devices for Sensitive and Selective determination of Mercury in Water Samples ปุริม จารุจำรัส Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-01-10
    ชื่อวารสาร
  • Analytical Sciences
    DOI
34 Comparison of reinforcing efficiency between calcium carbonate/carbon black and calcium carbonate/silica hybrid filled natural rubber composites สราวุธ ประเสริฐศรี Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-01-01
    ชื่อวารสาร
  • Defect and Diffusion Forum
    DOI
35 Thiocyanate Free Ruthenium(II) Complexes for Dye Sensitized Solar Cells (DSSCs) รักเกียรติ จิตคติ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2018-01-01
    ชื่อวารสาร
  • Defect & Diffusion Forum
    DOI
36 DFT Study of Catalytic CO2 Hydrogenation over Pt-Decorated Carbon Nanocones: H2 Dissociation Combined with the Spillover Mechanism DFT Study of Catalytic CO2 Hydrogenation over Pt-Decorated Carbon Nanocones: H2 Dissociation Combined with the Spillover Mechanism

In this work, we investigate the catalytic role of platinum-decorated defective CNC (Pt/dCNC) in CO2 hydrogenation to formic acid (FA) by a density functional theory (DFT) approach. The reaction follows the equation CO2(g) + H2(g) → HCOOH(g). Combining highly reactive Pt atoms with defective CNC provides Pt/dCNC, a reactive monodispersed atomic catalyst for CO2 hydrogenation. We propose our new mechanism of CO2 hydrogenation over the Pt/dCNC catalyst involving a H2 dissociation and H spillover sequence that is energetically favorable. The rate-determining step is formic acid desorption that requires an energy barrier of 1.11 eV. Furthermore, our findings show that the rate of FA production is dependent on H2 concentration. Altogether, the theoretical results support the concept of the spillover mechanism, playing a key role in promoting CO2 hydrogenation via a formate intermediate. These results improve our understanding of the mechanism involving H2 dissociation with the H spillover process and the catalytic reactions that are very important for the development of highly efficient catalysts for CO2 conversion into FA.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-12-26
    ชื่อวารสาร
  • The Journal of Physical Chemistry C
37 A highly sensitive fenobucarb electrochemical sensor based on graphene nanoribbons-ionic liquid-cobalt phthalocyanine composites modified on screen-printed carbon electrode coupled with a flow injection analysis A highly sensitive fenobucarb electrochemical sensor based on graphene nanoribbons-ionic liquid-cobalt phthalocyanine composites modified on screen-printed carbon electrode coupled with a flow injection analysis

A sensitive and rapid method for the determination of fenobucarb by using screen-printed carbon electrode modified with graphene nanoribbons - ionic liquid - cobalt phthalocyanine (GNRs-IL-CoPc/SPCE) composites based on flow injection analysis (FIA) was developed and applied to vegetable samples. The prepared GNRs-IL-CoPc composite was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and atomic force microscopy (AFM). Moreover, cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) were used to characterize the electrochemical behavior of the modified SPCE. The amperometric current responses were obtained from the oxidation of 2-sec-butyl-phenol, which is the product of alkaline hydrolysis of fenobucarb. The optimization of chemical variables and instrumental analysis such as composite amounts, pH, applied potential, and flow rate were carried out to obtain the best measurement. Under the optimal conditions, the proposed sensor yielded sensitivity of 0.0884 M/A·cm2, a wide linear range for detection of fenobucarb from 0.025 to 110 μM with a low detection, and quantification limits of 0.0089 μM and 0.0252 μM, respectively. Additionally, the developed sensor showed good repeatability (RSD = 3.5%, n = 10 measurements) and good reproducibility (RSD = 3.9%, n = 5 sensors). The proposed method could be effectively applied for the determination of fenobucarb in vegetable samples.

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-12-15
    ชื่อวารสาร
  • Journal of Electroanalytical Chemistry
38 Screen-printed microfluidic paper-based analytical device (μPAD) as a barcode sensor for magnesium detection using rubber latex waste as a novel hydrophobic reagent Screen-printed microfluidic paper-based analytical device (μPAD) as a barcode sensor for magnesium detection using rubber latex waste as a novel hydrophobic reagent

This work reports the first use of cis-1,4-polyisoprene obtained from rubber latex (RL) waste as the hydrophobic reagent for the fabrication of a microfluidic paper-based analytical device (mPAD), providing a user-friendly means for magnesium detection. The mPAD was fabricated using a screen printing technique and the barcode-like paper sensor was then used for the detection of Mg(II) ions in RL and water samples. Using different types of paper media (paper towel, Whatman No.1 and Whatman No.4), the results indicate that the key factors in optimizing the quality of the fabricated mPAD include the viscosity of cis-1,4-polyisoprene solution which could be adjusted using different solvents and heating temperatures, the mesh screen size, the pore size of the paper substrates, and the dimension of the sample zone. The fabricated mPAD, which showed high chemical resistance, durability and design flexibility, was tested for the detection of Mg(II) ions using the reaction based on complexometric titration with EDTA where Eriochrome Black T was used as an indicator. An Android application “UBU OMg Sensor” was also developed to provide a simple, fast, and accurate means for end-users to interpret results generated by our developed mPAD .

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-11-15
    ชื่อวารสาร
  • Analytica Chimica Acta
39 Novel amperometric flow-injection analysis of creatinine using a molecularly-imprinted polymer coated copper oxide nanoparticle-modified carbon-paste-electrode Novel amperometric flow-injection analysis of creatinine using a molecularly-imprinted polymer coated copper oxide nanoparticle-modified carbon-paste-electrode

We report a novel amperometric flow-injection (FI) analysis of creatinine based on a sensor comprising copper oxide nanoparticles (CuO) coated with a molecularly-imprinted polymer (CuO@MIP) and decorating a carbon-paste electrode (CPE) to form the CuO@MIP/CPE electrode. The CuO@MIP was synthesized by using CuO as the supporting core, creatinine as the template, methacrylic acid (MAA) as monomer, N, N′-(1,2-dihydroxyethylene)bis(acrylamide) (DHEBA) as cross-linker, and 2,2′-azobis (2-methylpropionitrile) (AIBN) as initiator. Morphology and structural characterization reveal that CuO nanoparticle imprinted sites (CuO) synthesized using a precipitation method, exhibits features that are well suited to creatinine detection: high surface area, good analyte diffusion and adsorption characteristics that provide shorter response times, and large numbers of specific cavities for enhanced analyte capacity and sensitivity. Cyclic voltammetric measurements indicate that our sensor provides excellent performance toward electro-oxidation of creatinine. The amperometric FI system was used to quantitatively determine creatinine at the CuO@MIP/CPE sensor, in a phosphate buffer carrier. The imprinted sensor exhibits excellent performance for creatinine oxidation at an applied potential of +0.35 V and flow rate of 0.6 mL.min−1. The as-prepared sensor exhibits a linear dynamic range for creatinine detection from 0.5 to 200 μM (r2 = 0.995) with a limit of detection of 0.083 μM (S/N = 3). The system exhibits satisfactorily good precision (%RSD = 1.94%, n = 30) and selectivity toward creatinine. There is only approximately 20% loss from initial response after 2 weeks when stored at 4 oC. We successfully applied the FI detection system to detect creatinine in human urine samples.

มะลิวรรณ อมตธงไชย Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-10-25
    ชื่อวารสาร
  • Journal of Pharmaceutical and Biomedical Analysis
    DOI
40 Highly sensitive and selective electrochemical paper-based device using a graphite screen-printed electrode modified with molecularly imprinted polymers coated Fe3O4@Au@SiO2 for serotonin determination Highly sensitive and selective electrochemical paper-based device using a graphite screen-printed electrode modified with molecularly imprinted polymers coated Fe3O4@Au@SiO2 for serotonin determination

Herein, we propose a highly sensitive and selective three-dimensional electrochemical paper-based analytical device (3D-ePAD) to determine serotonin (Ser). It uses a graphite-paste electrode modified with nanoparticles coated with molecularly imprinted polymer (MIP). Fe3O4@Au nanoparticles were encapsulated with silica to create novel nano-sized MIP. Morphology and structural characterization reveal that silica imprinted sites (Fe3O4@Au@SiO2) synthesized via sol-gel methods provide excellent features for Ser detection, including high porosity, and greatly improve analyte diffusion and adsorption to provide a faster response by the MIP sensor. The template molecule was effectively removed by solvent extraction to provide a greater number of specific cavities that enhance analyte capacity and sensitivity. The 3D-ePAD was fabricated by alkyl ketene dimer (AKD)-inkjet printing of a circular hydrophobic detection zone on filter paper for application of aqueous samples, coupled with screen-printed electrodes on the paper, which was folded underneath the hydrophobic zone. The sensor was constructed by drop coating of Fe3O4@Au@SiO2-MIP nanocomposites on the graphite electrode (GPE) surface. The MIP sensor (Fe3O4@Au@SiO2-MIP/GPE) was used in the detection of Ser by linear-sweep voltammetry (LSV) in 0.1 M phosphate buffer at pH 8.0. The device exhibits high sensitivity toward Ser, which we attribute to synergistic effects between catalytic properties, electrical conductivity of Fe3O4@Au@SiO2, and significantly increased numbers of imprinted sites. Ser oxidation was observed at +0.39 V. Anodic peak currents for Ser show linearity from 0.01 to 1000 μM (y = 0.0075 ± 0.0049 x + 0.4071 ± 0.0052, r2 = 0.993), with a detection limit of 0.002 μM (3S/N). The device provides good repeatability (%relative standard deviations; RSD) = 4.23%, calculated from the current responses of ten different MIP sensors). The device also exhibits high selectivity and reproducibility (%RSD = 8.35%, obtained from five calibration plots). The analytical performance of the device is suitable for the determination of Ser in pharmaceutical capsules and urine samples.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-10-24
    ชื่อวารสาร
  • Analytica Chimica Acta
    DOI
41 Novel Three-Dimensional Molecularly Imprinted Polymer-Coated Carbon nanotubes (3D-CNTs@MIP) for Selective Detection of Profenofos in Food Novel three-Dimensional molecularly imprinted polymer-coated carbon nanotubes (3D-CNTs@MIP) for selective detection of profenofos in food

A new and facile method for selective measurement of profenofos (PFF) using a simple flow-injection system with a molecularly-imprinted-polymer-coated carbon nanotube (3D-CNTs@MIP) amperometric sensor is proposed. The 3D-CNTs@MIP was synthesized by successively coating the surface of carboxylated CNTs with SiO2 and vinyl end groups, then terminating with molecularly imprinted polymer (MIP) shells. MIP was grafted to the CNT cores using methacrylic acid (MAA) monomer, ethylene glycol dimethacrylate (EGDMA) as cross linker, and 2,20 -azobisisobutyronitrile (AIBN) as initiator. We constructed the PFF sensor by coating the surface of a glassy carbon electrode (GCE) with 3D-CNTs@MIP and removed the imprinting template by solvent extraction. Morphological and structural characterization reveal that blending of the MIP on the CNT surface significantly increases the selective surface area, leading to greater numbers of imprinting sites for improved sensitivity and electron transfer. The 3DCNTs@MIP sensor exhibits a fast response with good recognition when applied to PFF detection by cyclic voltammetry and amperometry. The PFF oxidation current signal appears at þ0.7 V vs Ag/AgCl using 0.1 M phosphate buffer (pH 7.0) as the carrier solution. The designed 3D-imprinted sensor provides a

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-10-17
    ชื่อวารสาร
  • Analytica Chimica Acta
    DOI
42 In silico study directed towards identification of the key structural features of GyrB inhibitors targeting MTB DNA gyrase: HQSAR, CoMSIA and molecular dynamics simulations In silico study directed towards identification of the key structural features of GyrB inhibitors targeting MTB DNA gyrase: HQSAR, CoMSIA and molecular dynamics simulations

Mycobacterium tuberculosis DNA gyrase subunit B (GyrB) has been identified as a promising target for rational drug design against fluoroquinolone drug-resistant tuberculosis. In this study, we attempted to identify the key structural feature for highly potent GyrB inhibitors through 2D-QSAR using HQSAR, 3D-QSAR using CoMSIA and molecular dynamics (MD) simulations approaches on a series of thiazole urea core derivatives. The best HQSAR and CoMSIA models based on IC50 and MIC displayed the structural basis required for good activity against both GyrB enzyme and mycobacterial cell. MD simulations and binding free energy analysis using MM-GBSA and waterswap calculations revealed that the urea core of inhibitors has the strongest interaction with Asp79 via hydrogen bond interactions. In addition, cation-pi interaction and hydrophobic interactions of the R2 substituent with Arg82 and Arg141 help to enhance the binding affinity in the GyrB ATPase binding site. Thus, the present study provides crucial structural features and a structural concept for rational design of novel DNA gyrase inhibitors with improved biological activities against both enzyme and mycobacterial cell, and with good pharmacokinetic properties and drug safety profiles.

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-10-14
    ชื่อวารสาร
  • SAR AND QSAR IN ENVIRONMENTAL RESEARCH
    DOI
43 FeIIFeIII layered double hydroxide nanosheets (FeIIFeIII LDHNS) as an enzyme mimic for colorimetric detection of H2O2 FeIIFeIII layered double hydroxide nanosheets (FeIIFeIII LDHNS) as an enzyme mimic for colorimetric detection of H2O2

In this study, a new, rapid, sensitive, and convenient approach for colorimetric detection of H2O2 using FeIIFeIII layered double hydroxide nanosheets (FeIIFeIII LDHNS) is reported. The FeIIFeIII LDHNS were constructed from a mixture of divalent and trivalent Fe ions by a co-precipitation method. FeIIFeIII LDHNS were found to possess superior intrinsic peroxidase-like activity. They were used to catalyze the oxidation of a peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) diammonium salt in the presence of H2O2 to produce a blue and green solution product, respectively, that provided colorimetric detection of H2O2. The colorimetric detection of H2O2 was conveniently carried out by incubating at room temperature. Moreover, for the ABTS substrate, the experiment was facilely and successfully carried out in deionized water at a pH of approximately 5.6. The colorimetric assays displayed linearity for H2O2 determination by using TMB and ABTS systems in the range of 0.1–50 μM and 0.5–20 μM, respectively, and the corresponding limits of detection were found to be 0.05 μM and 0.2 μM, respectively. The catalytic reaction follows Michaelis–Menten kinetics and exhibits strong affinity towards TMB, ABTS, and H2O2 substrates. This selective approach could be applied for H2O2 detection in real milk and disinfectant samples. It is expected that there is great potential for the proposed method for exact detection of H2O2 in biotechnology, clinical diagnoses, the food industry, and other industries

สุภาพ ตาเมือง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-10-07
    ชื่อวารสาร
  • Analytical Methods
    DOI
44 Photophysical Properties of Functionalized Double Decker Phenylsilsesquioxane Macromonomers: [PhSiO1.5]8[OSiMe2]2 and [PhSiO1.5]8[O0.5SiMe3]4. Cage-Centered Lowest Unoccupied Molecular Orbitals Form Even When Two Cage Edge Bridges Are Removed, Verified by Modeling and Ultrafast Magnetic Light Scattering Experiments hotophysical Properties of Functionalized Double Decker Phenylsilsesquioxane Macromonomers: [PhSiO1.5]8[OSiMe2]2 and [PhSiO1.5]8[O0.5SiMe3]4. Cage-Centered Lowest Unoccupied Molecular Orbitals Form Even When Two Cage Edge Bridges Are Removed, Verified by Modeling and Ultrafast Magnetic Light Scattering Experiments

Bromination and iodination of title double decker (DD) phenylsilsesquioxane macromonomers occurs at ortho and para positions, respectively, as in PhT8,10,12 cages. Heck cross-coupling with 4-Me/CNstyrene gives the corresponding 4-Me/CNstilbene-substituted cages. All compounds were characterized by FTIR, MALDI-TOF, TGA, NMR and GPC. These compounds show UV−vis absorptions very similar to individual stilbene analogues. However, emission for all macromonomers, except p-MeStil2Ph6DD(OTMS)4, is redshifted 50−70 nm as seen before in full and partial cages centered LUMOs conjugated to all the stilbene moieties suggesting semiconducting behavior. Cagecentered LUMO formation even occurs in a DD cage where two of four Si−O−Si bridges are broken suggesting that LUMO formation is an extremely common phenomenon. These results are supported by both modeling studies and nonlinear light scattering in which magnetic dipole moments form and scatter light in the cage centers. The exception behaves like p-methylstilbene in both absorption and emission indicating that the onset of semiconducting behavior requires a minimum number of substituents and points to the potential to tailor band gaps and therefore multiple photophysical properties.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-09-26
    ชื่อวารสาร
  • Macromolecules
45 Development of a novel three-dimensional microfluidic paper-based analytical device (3D-µPAD) for chlorpyrifos detection using graphene quantum-dot capped gold nanocomposite for colorimetric assay Development of a novel three-dimensional microfluidic paper-based analytical device (3D-µPAD) for chlorpyrifos detection using graphene quantum-dot capped gold nanocomposite for colorimetric assay

This report presents a three-dimensional microfluidic paper-based analytical device (3D-μPAD) with colorimetric assay, for chlorpyrifos organophosphate pesticide detection in vegetable samples. The 3DµPAD was fabricated by one-step polymer-screen-printing, using rubber latex (RL) waste as a hydrophobic reagent for low-cost and simple manufacture. The 3D-µPAD design comprises two sheets; a testing sheet containing two circular zones, and a sampling sheet in the shape of a dumbbell design. Assay involves the acetylcholinesterase (AChE)-catalysed hydrolysis of an acetylthiocholine (ATCh) substrate to produce thiocholine. Thiocholine causes the aggregation of graphenequantum-dot capped gold-nanocomposite particles (GQD-AuNPs) to give a purple–blue-coloured solution. Incubation with chlorpyrifos inhibits the hydrolysis reaction, resulting in anti-aggregation of redcoloured GQD-AuNPs. The assay can determine chlorpyrifos by ImageJ detection, over a linear range of 0.001 to 1.0 µg mL−1 , with a detection limit of 0.0007 µg mL−1 , without sophisticated instrumentation. The developed 3D-µPAD was applied to detect chlorpyrifos in spiked vegetable samples, with per cent recoveries ranging from 93.0% to 104.6%. Our developed device provides good precision (%RSD ranges from 0.3 to 1.6). The calculated relative error comparison with HPLC ranges from 1.0% to 5.2%, indicating a high degree of accuracy. The 3D-µPAD exhibits good sensitivity and selectivity for a low-cost and rapidscreening test for the presence of insecticides, and might be useful for on-site applications.

มะลิวรรณ อมตธงไชย Q4 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-08-07
    ชื่อวารสาร
  • International Journal of Environmental Analytical Chemistry
    DOI
46 A non-toxic approach to assess total antioxidant capacity (TAC) of exotic tropical fruits from Thailand A non-toxic approach to assess total antioxidant capacity (TAC) of exotic tropical fruits from Thailand

A simple flow injection analysis (FIA) integrating with a metal-free approach for total antioxidant capacity (TAC) was developed. The non-toxic reaction was based on generating a vibrant blue radical from imipramine to avoid the potential interferents arising from the colorful fruit extracts. The blue radical can be rapidly scavenged by antioxidant compounds present in the sample. TAC values of Thai tropical fruit extracts were assessed by monitoring the quenching in absorbance of the test mixture following the addition of the antioxidant compounds/fruit extracts. The FIA co-operated in order to increase the sample throughput. The results demonstrated that Antidesma thwaiteaianum Muell. Arg. has the highest capacity followed by Terminalia chebula Retz. and Phyllanthus Emblica Linn., respectively. An excellent correlation between the proposed method was found with the DPPH assay. The proposed method allowed the TAC determination of fruit extracts in a high-throughput and straightforward way in accordance with the principles of green analytical chemistry.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-07-12
    ชื่อวารสาร
  • Journal of Food Science and Technology
    DOI
47 การศึกษาฤทธิ์ในการต้านอนุมูลอิสระและปริมาณฟีนอลิกรวมของสารสกัดข้าวกล้องงอก สมจินตนา ทวีพานิชย์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-07-11
    ชื่อวารสาร
  • เอกสารสืบเนื่องจากการประชุมวิชาการ มอบ.วิจัย ครั้งที่ 13
    DOI
48 Starch hydrogel-loaded cobalt nanoparticles for hydrogen production from hydrolysis of sodium borohydride Starch hydrogel-loaded cobalt nanoparticles for hydrogen production from hydrolysis of sodium borohydride

In this work, starch hydrogel was successfully prepared using a citric acid cross-linking method and then was utilized in the preparation of starch hydrogel-loaded cobalt nanoparticles (CoNPs) by the reduction of Co2+ ions loaded within the starch hydrogel network. The swelling behavior of starch hydrogel as a function of temperature and pH was also investigated. The resulting hydrogel-loaded CoNPs were confirmed using a number of techniques including powder x-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), selected area electron diffraction (SAED) and thermogravimetric analysis (TGA). The activity of starch hydrogel-loaded CoNPs was evaluated by employing them as a catalyst for the hydrogen production from the hydrolysis of sodium borohydride (NaBH4). The activation energy (Ea) was 52.18 kJ mol−1 ; whereas, the activation enthalpy (ΔH#) and activation entropy (ΔS#) were 49.54 kJ mol−1 and −138.61 kJ mol−1 , respectively. The activity of starch hydrogel-loaded CoNPs maintained over the 5 cycles of utilization. Due to its biocompatibility, flexibility and nontoxicity, starch hydrogel could be considered as a promising candidate to be used as a template for the preparation of metal nanoparticles in the hydrogen production and even in catalysis of other reactions.

เสนอ ชัยรัมย์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-06-14
    ชื่อวารสาร
  • Advances in Natural Sciences: Nanoscience and Nanotechnology
    DOI
49 Optimization of Ultrasonic-Assisted Extraction and Purification of Rhein from Cassia fistula Pod Pulp Optimization of Ultrasonic-Assisted Extraction and Purification of Rhein from Cassia fistula Pod Pulp

: Rhein is used as an active ingredient in laxatives in medicinal herbal products and is a chemical marker for quality control purposes. Thus, a simple and effective method for the optimized extraction of a high amount of rhein from the fruit pulp of Cassia fistula was investigated using ultrasonic-assisted extraction (UAE). The response surface methodology was applied to find the most suitable parameters for optimizing the extraction process and to study the factors’ relationships with each other. The best conditions for ultrasonic extraction were the application of 1:40 g/mL solid-to-liquid ratio and 10% EtOH–H2O as a solvent at 75 ◦C for 40 min. This method was compared to a conventional decoction in two variations. In these experiments, it was confirmed that the UAE was more favorable than the decoction methods. The resulting crude extract was further purified by liquid–liquid extraction with a basic pH adjustment, followed by recrystallization. High-purity rhein was obtained by using chromatographic techniques and nuclear magnetic resonance spectroscopy. Therefore, this study suggests that UAE is an efficient alternative method for the extraction of rhein from C. fistula pod pulp. The resulting optimized conditions can be applied as a useful tool for the large-scale industrial production of a rhein-rich plant extract.

นิภาวรรณ พองพรหม Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-05-02
    ชื่อวารสาร
  • Molecules
    DOI
50 Bioactive oxaphenalenone dimers from the fungus Talaromyces macrosporus KKU-1NK8 ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-04-01
    ชื่อวารสาร
  • Fitoterapia
    DOI
51 Novel biodegradable hydrogel based on natural polymers: synthesis, characterization, swelling/reswelling and biodegradability สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-03-01
    ชื่อวารสาร
  • European Polymer Journal
    DOI
52 Use of unmodified silver nanoparticles (AgNPs) as colorimetric Hg(II) sensor: A new approach to sensitive and high sample throughput determination of Hg(II) under high influence of ionic suppression Use of unmodified silver nanoparticles (AgNPs) as colorimetric Hg(II) sensor: A new approach to sensitive and high sample throughput determination of Hg(II) under high influence of ionic suppression

Facile unmodified silver nanoparticles (AgNPs) as colorimetric sensor for determination of Hg(II) ions in aqueous samples were developed using UV-Vis spectrophotometry. Abrupt change in absorbance of the AgNPs was observed, which progressively decreased and slightly shifted to the blue wavelength as the concentration of Hg(II) increased. It appears that the AgNPs were oxidized by Hg(II), resulting in disintegration of the AgNPs and Hg(0). Deposition of Hg(0) on the surface of AgNPs also occurred, resulting in amalgam particles of mercury (Hg-Ag). Interestingly, the developed approach showed a significant enhancement in the Hg(II) analytical sensitivity when formic acid was doped onto the AgNPs, with the linearity range of 0.01–10 mg L−1 (r2 = 0.999) providing the quantitative detection limit of 0.007 mg L−1 (3SD blank/slope of the calibration curve). Greater selectivity toward Hg(II) over other ions and colour dyes was also observed, likely a result of stabilization by polyvinylpyrrolidone (PVP), which kept the AgNPs well-stabilized and dispersed in the bulk aqueous environment making them resistant to ionic suppression. Under using a 96-well microplate and a smartphone equipped with homemade application as a colorimetric analyzer under controlled lighting, high sample throughput (128 sample h−1, n = 4) was achieved, establishing its potential for practical analysis. The percentage recoveries of spiked aqueous samples obtained from the microplate-based system were in acceptable range, in agreement with the values obtained from the UV-Vis spectrophotometry-based system. The proposed colorimetric sensor has been shown to provide a rapid, simple, sensitive and selective detection of Hg(II) ions in various aqueous samples.

ปุริม จารุจำรัส Q4 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-03-01
    ชื่อวารสาร
  • International Journal of Environmental Analytical Chemistry
    DOI
53 Interaction and structural requirement of 4-thiazolidinone (rhodanine) inhibitors as potential anti-tuberculosis agents: MD simulations พรพรรณ พึ่งโพธิ์ ยังไม่มีระดับ Quartile Scor นานาชาติ
    วันที่ตีพิมพ์
  • 2019-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2019 (PACCON 2019)
    DOI
54 Molecular docking calculations of novel pyrrolyl benzohydrazide and pyrrolyl benzamide derivatives InhA inhibitors as anti-tuberculosis agents พรพรรณ พึ่งโพธิ์ ยังไม่มีระดับ Quartile Scor นานาชาติ
    วันที่ตีพิมพ์
  • 2019-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2019 (PACCON 2019)
    DOI
55 Utilization of zeolites synthesized from water sludge for study of manganese treatment in wastewater มาลี ประจวบสุข ยังไม่มีระดับ Quartile Scor นานาชาติ
    วันที่ตีพิมพ์
  • 2019-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2019 (PACCON 2019)
    DOI
56 Removal of Anionic Dyes from Aqueous Solution using Surfactant Modification of Ranong White Clay as Highly Potential Adsorbent พรพรรณ พึ่งโพธิ์ ยังไม่มีระดับ Quartile Scor นานาชาติ
    วันที่ตีพิมพ์
  • 2019-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2019 (PACCON 2019)
    DOI
57 Removal of industrial dyes from aqueous solution using geopolymer from metakaolin as a highly potential adsorbent สายสมร ลำลอง ยังไม่มีระดับ Quartile Scor นานาชาติ
    วันที่ตีพิมพ์
  • 2019-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference (PACCON2019)
    DOI
58 Development of Agricultural Waste for Reuse Catalyst สายสมร ลำลอง ยังไม่มีระดับ Quartile Scor นานาชาติ
    วันที่ตีพิมพ์
  • 2019-02-07
    ชื่อวารสาร
  • Pure and Applied Chemistry International Conference 2019 (PACCON 2019)
    DOI
59 A direct and sensitive electrochemical sensing platform based on ionic liquid functionalized graphene nanoplatelets for the detection of bisphenol A A direct and sensitive electrochemical sensing platform based on ionic liquid functionalized graphene nanoplatelets for the detection of bisphenol A

A simple electrochemical sensor for bisphenol A (BPA) was developed based on a composite of graphene nanoplatelets (GNPs) and 1-butyl-2, 3-dimethylimidazolium tetrafluoroborate (ionic liquid, IL) as a modifier for glassy carbon paste electrodes (GCPEs). Scanning electron (SEM) and atomic force microscopy (AFM) were employed to characterize the morphology and surface modification. The electrochemical behavior of BPA on IL-GNP/GCPEs was investigated and the results showed that IL-GNP composites enhance the electrochemical signal toward BPA due to the synergetic effect of GNPs and IL. The experimental parameters including the amount of IL and GNPs, pH of solution, pulse potential, step potential, and scan rate were optimized. Under optimal conditions, the proposed sensor exhibited a linear relationship between signal and BPA concentrations ranging from 0.02–5.0 μM, with detection and quantification limits of 6.4 nM and 0.02 μM respectively. Moreover, the electrochemical sensor showed good repeatability (RSD = 3.3%, n = 5 measurements), good reproducibility (RSD = 3.8%, n = 5 sensors), high accuracy of 95.3–104.5% recovery, acceptable selectivity, and stability. The sensor was successfully applied to the determination of BPA in water samples in contact with plastic materials. The results were satisfactory and in agreement with reference values from a standard HPLC method.

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2019-01-15
    ชื่อวารสาร
  • Journal of Electroanalytical Chemistry
60 Development of multicomponent interpenetrating polymer network (IPN) hydrogel films based on 2-hydroxyethyl methacrylate (HEMA), acrylamide (AM), polyvinyl alcohol (PVA) and chitosan (CS) with enhanced mechanical strengths, water swelling and antibacterial properties Development of multicomponent interpenetrating polymer network (IPN) hydrogel films based on 2-hydroxyethyl methacrylate (HEMA), acrylamide (AM), polyvinyl alcohol (PVA) and chitosan (CS) with enhanced mechanical strengths, water swelling and antibacterial properties

The novel poly(2-hydroxyethyl methacrylate-co-acrylamide)/polyvinyl alcohol/chitosan (P(HEMA-co-AM)/PVA/CS) interpenetrating polymer network (IPN-CS) hydrogel films were fabricated by two-step free radical polymerization, aiming to enhance the tensile strength, water swelling and antibacterial activity compared to P(HEMA-co-AM)/PVA hydrogel (IPN-0%CS). The different weight ratios of PVA and CS components were firstly crosslinked by glutaraldehyde. Then P(HEMA-co-AM) copolymers were interpenetrated into the primary networks of PVA/CS and crosslinked by ethylene glycol dimethacrylate to form the IPN-CS hydrogels. The functional group analysis confirmed that the IPN-CS hydrogels were successfully synthesized. The crystallinity, Tg and Tm, microporous and surface area of IPN-CS hydrogels tended to increase significantly with increasing CS content. The swelling equilibrium and surface area of IPN-CS hydrogel exhibited a linearly relationship with CS content. The swelling behavior of IPN-CS hydrogels was best described by the pseudo-first order kinetics and followed a non-Fickian diffusion mechanism. The IPN-5%CS hydrogel film exhibited the highest tensile strength (22.4 MPa) which was increased 2.7 folds of IPN-0%CS. All IPN-CS hydrogels demonstrated an excellent antibacterial activity against E. coli. These results suggest that the IPN-CS hydrogel films have promising potential used as wound dressings.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-11-01
    ชื่อวารสาร
  • Reactive and Functional Polymers
61 Novel amino-containing molecularly-imprinted polymer coating on magnetite-gold core for sensitive and selective carbofuran detection in food Novel amino-containing molecularly-imprinted polymer coating on magnetite-gold core for sensitive and selective carbofuran detection in food

We report a novel and facile method for synthesis of amino-containing molecularly-imprinted coatings on magnetite-gold nanoparticle cores (Fe3O4@Au-MIP-NH2) for constructing robust and sensitive carbofuran sensors. Fe3O4@Au-MIP-NH2 nanoparticles were synthesized by successive self-assembly of organic thiols, 11–mercaptoundecanoic acid, on magnetite-gold core surfaces, followed by coupling with an amino-containing molecularly-imprinted polymer (MIP-NH2) shells. The MIP-NH2 nanocomposite was synthesized via two polymerization steps to form carbofuran imprinted pre-polymer nanoparticles and then terminating the surface with amino-containing polymer. The synthesized pre-polymer nanoparticles possess a large surface-to-volume ratio. This approach allows for increased numbers of carbofuran template molecules to attach to the polymer surface to form larger recognition sites. We constructed the highly sensitive and selective carbofuran amperometric sensor by coating the surface of a glassy carbon electrode with Fe3O4@Au-MIP-NH2 coupled with a simple flow-injection system. Morphological and structural characterization reveals that the coupling of the MIP-NH2 on the Fe3O4@Au core surface significantly increases the recognition surface area and electron transfer efficiency to provide improved selectivity and sensitivity. The MIP-NH2 modified electrode shows substantially enhanced carbofuran current response, which is by a factor of about twenty times that of the non-imprinted polymer electrode. The modified electrode provides fast response with good selectivity when applied to carbofuran detection by amperometry. The carbofuran oxidation-current signal appears at + 0.50 V vs Ag/AgCl, using 0.1 M phosphate buffer (pH 7.0) as the carrier solution. The designed Fe3O4@Au-MIP-NH2 sensor provides a linear response over the range 0.01–100 µM (r2 = 0.9967) with a low detection limit of 1.7 nM. The intraday and inter-day precision (%RSD) of 5 µM CBF are 1.4% and 1.8%, respectively. We demonstrate the successful application of the sensor to the detection of CBF in fruit and vegetable samples.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-11-01
    ชื่อวารสาร
  • Microchemical Journal
62 Local structure elucidation and reaction mechanism of light naphtha aromatization over Ga embedded H-ZSM-5 zeolite: Combined DFT and experimental study Local structure elucidation and reaction mechanism of light naphtha aromatization over Ga embedded H-ZSM-5 zeolite: Combined DFT and experimental study

Local structures and mechanisms for n-pentane aromatization on Ga embedded H-ZSM-5 zeolite (Ga/ZSM-5) were elucidated using Synchrotron-based X-ray absorption spectroscopy (XAS) and density functional theory (DFT) calculations to understand the role of Ga/ZSM-5 zeolite in aromatics synthesis. XAS data suggests that Ga ligates with four oxygen or four hydrogen atoms. Catalytic tests results suggest that conversion by Ga/ZSM-5 catalyst cannot occur via C6–C8 non-aromatic intermediates, while the availability of Ga metal sites promotes the aromatization of C2 and C3 species. Therefore, conversion of n-pentane to benzene or toluene comprises four steps, i) cracking, ii) GaH2 activation, iii) cyclization, and iv) dehydrogenation. Our model predicts the key intermediate in n-pentane aromatization on Ga/ZSM-5 zeolite to be a five-membered Ga-C4 ring structure. The ring undergoes expansion to form a seven-membered Ga-C6 ring. Moreover, we discuss thermodynamics and kinetic results for the benzene and toluene formation pathways. Our results provide new finding for the role of Ga/ZSM-5 zeolites in n-pentane aromatization processes.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-10-15
    ชื่อวารสาร
  • Microporous and Mesoporous Materials
    DOI
63 Removal of H2S to produce hydrogen in the presence of CO on a transition metal-doped ZSM-12 catalyst: a DFT mechanistic study Removal of H2S to produce hydrogen in the presence of CO on a transition metal-doped ZSM-12 catalyst: a DFT mechanistic study

Hydrogen sulfide (H2S) leads to corrosion in transport lines and poisoning of many catalysts. Meanwhile, H2S is an inexhaustible potential source of hydrogen, which is a very valuable chemical reagent and an environmentally friendly energy product. Therefore, removal of H2S and producing hydrogen gas using potential catalysts has been intensively studied, according to the equation: H2S(g) + CO(g) → COS(g) + H2(g). In this study, hydrogen sulfide (H2S) decomposition in the presence of CO over transition metal-doped ZSM-12 clusters (TM-ZSM-12) has been investigated based on DFT calculations at the B3LYP-D3/6-31G(d,p) level. The calculation results reveal that the proposed reaction mechanism is controlled by 4 key steps, (i) hydrogen dissociation (Ea1 = +0.04 eV for the 1st hydrogen and Ea2 = +0.22 eV for the 2nd hydrogen), (ii) COS desorption (the rate-determining step of this H2S removal process, Edes = +1.18 eV), (iii) hydrogen diffusion to the transition metal with an energy barrier (Ea3) of +0.62 eV, and (iv) the H2 formation step (Ea4 = +0.94 eV). Our results indicate that in the presence of CO, the Cu–ZSM-12 cluster has a potential application as a highly active catalyst for H2S removal together with hydrogen production.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-09-21
    ชื่อวารสาร
  • Physical Chemistry Chemical Physics
    DOI
64 Classification of alcohols obtained by QCM sensors with different characteristics using ABC based neural network Classification of alcohols obtained by QCM sensors with different characteristics using ABC based neural network

Alcohols with different structures are used frequently in hygiene products and cosmetics. It is desirable to classify these alcohols to evaluate their potential harmful effects using less costly methods. In this study, five different types of alcohol are classified using five QCM sensors with different structures. The main idea of the study is to determine the QCM sensor that makes the most successful classification. All the five of the QCM sensors gave successful results, but QCM12-constructed using only NP-was the most successful. ABC-based ANN is used for the classification, and the lowest MSE value in test dataset is obtained as 1.41E−16. The results of 300 different scenarios showed that different alcohols can be classified successfully by using ANN-ABC on the sensor data from QCM12.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-06-01
    ชื่อวารสาร
  • Engineering Science and Technology, an International Journal
    DOI
65 Preparation and characterization of natural rubber bio-based wood adhesive: effect of total solid content, viscosity, and storage time Preparation and characterization of natural rubber bio-based wood adhesive: effect of total solid content, viscosity, and storage time

Natural rubber (NR) grafted by methyl methacrylate (MMA) was used to produce bio-based wood adhesive. The efect of total solid content (%TSC) at 55, 57, and 60%, represented as 55NR-g-MMA, 57NR-g-MMA, and 60NR-g-MMA, respectively, and the efect of storage time on lap shear strength were investigated. It was found that contact angle sharply decreased from 95° for NR to approximately 65° for all of NR-g-MMAs. Because the MMA groups were incorporated into various NRg-MMA samples and the highest relative amount of grafted MMA was obtained by 57-NR-g-MMA which is determined by peaks intensities ratio between wave number at 1725 (C=O stretching) and 1450 (CH2 stretching), investigated by attenuated total refectance Fourier transform infrared spectroscopy (ATR-FTIR). These infuences resulted in an increase in storage modulus (E′), whereas tanδ was decreased as compared to that of NR, characterized by dynamic mechanical analyzer (DMA). In addition, the apparent viscosity performed by plate-and-plate rheometer trended to increase with total solid content and storage time. However, the highest lap shear strength was achieved by 57NR-g-MMA. It means that the lap shear strength was not only governed by viscosity as well as total solid content, but the amount of grafted MMA also plays an important role.

ศิริวัฒน์ ระดาบุตร Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-05-01
    ชื่อวารสาร
  • Polymer Bulletin
    DOI
66 Theoretical Mecchanistic study of Co Catalytic Oxidation by O2 on an Ultra-Small 13-Atom Bimetalliic Ag7Au6 Cluster Theoretical Mecchanistic study of Co Catalytic Oxidation by O2 on an Ultra-Small 13-Atom Bimetalliic Ag7Au6 Cluster

We report an advanced configurational sampling method that uses density functional theory (DFT) to design a highly active catalyst for conversion of CO into less-harmful products, under ambient conditions. The reaction pathway for CO oxidation by O2 on ultra-small 13-Atom bimetallic Ag7Au6 cluster has two possible mechanisms, namely, stepwise adsorption and co-adsorption. The rate-determining step involving with COeO association via a co-adsorption process shows a significantly small barrier of 0.21 eV. Furthermore, microkinetic simulation results suggest that CO oxidation rates and the optimal temperature for CO oxidation exhibit both greater performances for the co-adsorption pathway, compared to that for a stepwise-adsorption mechanism. Our new proposed mechanism suggests that the bimetallic Ag7Au6 catalyst is active for CO oxidation at room temperatures. Thus, it has potential application as a highly-active catalyst for conversion of carbon monoxide into less toxic CO2.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-04-05
    ชื่อวารสาร
  • Applied Catalysis A: General
    DOI
67 An ultrasensitive immunosensor based on manganese dioxide-graphene nanoplatelets and core shell Fe3O4@Au nanoparticles for label-free detection of carcinoembryonic antigen An ultrasensitive immunosensor based on manganese dioxide-graphene nanoplatelets and core shell Fe3O4@Au nanoparticles for label-free detection of carcinoembryonic antigen อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-04-01
    ชื่อวารสาร
  • Bioelectrochemistry
68 High coverage H2O adsorption on CuAl2O4 surface: A DFT study High coverage H2O adsorption on CuAl2O4 surface: A DFT study

Investigation into the interaction between water and surface is important for many reactions. Periodic DFT calculations were performed to investigate the adsorption of nH2O (n = 1–8) on the CuAl2O4 (1 0 0) and (1 1 0) surfaces. The results show that single water molecule is adsorbed on the CuAl2O4 (1 0 0) and (1 1 0) surfaces via dissociative adsorption with adsorption energies of −103 and −170 kJ/mol. On O-defective CuAl2O4 surfaces, the O atom of the water molecule prefers to insert into the O vacancy, leaving two isolated H atoms bonds to surface O atoms forming two in-surface hydroxyls. For nH2O (n = 2–8) on CuAl2O4 surfaces, molecular and dissociative water adsorption can coexist. The interaction of H2O with CuAl2O4 (1 1 0) surface is much stronger than with the (1 0 0) surface. The PDOS analysis revels that the adsorption of water on the surfaces is accompanied by charge transfer. Water adsorption on the CuAl2O4 surfaces leads to the decreases of the work function at low water coverage, while higher water coverage results in the increase of the work function. The phase diagrams of the water adsorption on the CuAl2O4 spinel surfaces show that water will desorb from the CuAl2O4 surfaces at higher temperature and lower H2O pressure.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-03-30
    ชื่อวารสาร
  • Applied Surface Science
69 Novel paper‐based colorimetric immunoassay (PCI) for sensitive and specific detection of salbutamol residues in flesh of swine and urine using Ag3PO4/Ag nanocomposite as label Novel paper‐based colorimetric immunoassay (PCI) for sensitive and specific detection of salbutamol residues in flesh of swine and urine using Ag3PO4/Ag nanocomposite as label

Salbutamol (SAL) can cause potential hazards to human health and its use as a growth promoter in meatproducing animals is illegal. This work reports a novel approach for competitive paper-based colorimetric immunoassay (PCI) using the Ag3PO4/Ag nanocomposite as label for sensitive and specific determination of SAL in flesh of swine and urine. The Ag3PO4/Ag nanocomposite was synthesized by a one-step chemical bath method, which could instantly oxidize a chromogenic substrate for the color development under acidic conditions without the participation of H2O2. This approach provides high affinity between the Ag3PO4/Ag nanocomposite and the substrate (with the Michaelis– Menten constant of 0.44 mM). In addition, the fabrication process of the PCI was simple and cost-effective. Particularly, the novel PCI also exhibits simplicity and cost-effectiveness of the fabrication process through a simple wax screenprinting, which requires inexpensive equipment and material including a screen, wax, a squeegee, and a hair dryer. Under optimal conditions, the competitive PCI exhibited a linearity range of 0.025 to 1.00 µg/L. The developed approach offers advantages over the conventional ELISA for the purpose of routine use because it requires a shorter incubation time (<1 hr), significantly small volumes of reagents and samples (<100 µL each), and an inexpensive consumer-grade digital camera coupled with a simple gray-scale transformation of the RGB (Red Green Blue) color image for the purpose of quantification of the detection.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-01-01
    ชื่อวารสาร
  • Journal of Food Science
70 0 0

We investigated metal-free dyes based on isoindigo by performing density functional theory and Time-dependent density functional theory calculations to improve the efficiency of dye-sensitized solar cells. The D–p¢–A¢–p–A organic dyes (TIDP and TIDT) used triphenylamine as donor, thiophene as the p¢-linker between the donor and auxiliary acceptor, and a phenyl or thiophene ring as the p-linker between the auxiliary acceptor and acceptor. TIDP and TIDT exhibit good charge-transfer properties. The TIDP-based device provides better device performance with a PCE of 4.11%. Calculated results reveal that the phenyl ring directly linking the auxiliary acceptor and acceptor causes a small tilt angle in the TiO2–adsorped dye, resulting in enhanced electroninjection rates, more efficient packing of adsorbed dye molecules, and slow charge recombination at the TiO2 surface. The performance of the TIDT-based device (g = 2.46%), arises from decreased electron-injection rates and fast charge recombination caused by the large dihedral angle of the adsorbed dye. This research identifies a potential p¢-linker group and reveals the influence of the p-linker on photovoltaic performance in organic dyes.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-01-01
    ชื่อวารสาร
  • Journal of ELECTRONIC MATERIALS
71 A new environment-friendly supramolecular solvent-based liquid phase microextraction coupled to high performance liquid chromatography for simultaneous determination of six phenoxy acid herbicides in water and rice samples A new environment-friendly supramolecular solvent-based liquid phase microextraction coupled to high performance liquid chromatography for simultaneous determination of six phenoxy acid herbicides in water and rice samples

A green supramolecular solvent (SUPRAS) has been ex situ synthesized and used as the extraction solvent for liquid phase microextraction (LPME) for six phenoxy acid herbicides including 2,4-dichlorophenoxyacetic acid (2,4-D), 2-methyl-4-chlorophenoxyacetic acid (MCPA), 2-(2,4-dichlorophenoxy)propanoic acid (Dichloprop), 2-(4-Chloro-2-methylphenoxy) propanoic acid (Mecoprop), 4-(2,4-dichlorophenoxy)butanoic acid (2,4-DB) and 4-(4-Chloro-2-methylphenoxy) butanoic acid (MCPB) before their analysis by HPLC. The SUPRAS was generated from the aggregation of sodium dodecyl sulfate (SDS) and tetrabutylammonium bromide (TBABr) at the molar ratio of 1:4, in the presence of AlCl3 at ambient temperature. The synthesized SUPRAS was found to be stable for at least one month and a single prepared batch can be used for extraction of 12 samples. The optimum conditions for the extraction were 20 µL of SUPRAS, 3.5% (w/v) of AlCl3, vortex for 20 s and centrifugation at 6000 rpm for 1 min. The micro-volume extraction phase was settled at the narrow bottom of the centrifugation tube allowing easy collection without any special equipment required, providing high efficiency and reproducibility for HPLC analysis. Under the optimum conditions, the method provided the enhancement factor of 37–149 with the limits of detection in the range of 1–2 µg L − 1. A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) was used for rice sample preparation before extraction and analysis by HPLC. The proposed method was successfully applied for the analysis of the studied herbicides in water and rice samples with the good percentage recovery ranged from 81–110 and 81–108, respectively.

เกษริน สีบุญเรือง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-01-01
    ชื่อวารสาร
  • Microchemical Journal
72 Aspertamarinolides A-C: gamma-butenolides from the marine-derived fungus Aspergillus tamarii PSU-MF90 Aspertamarinolides A-C: gamma-butenolides from the marine-derived fungus Aspergillus tamarii PSU-MF90

Three new γ-butenolides, aspertamarinolides A-C, were isolated from the marine-derived fungus Aspergillus tamarii PSU-MF90. Their structures with absolute configurations were elucidated by spectroscopic techniques, electronic circular dichroism (ECD) calculations and specific rotations. A plausible biosynthetic pathway for the isolated γ-butenolides was also proposed

ศิริพร จึงสุทธิวงษ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-11-12
    ชื่อวารสาร
  • TETRAHEDRON LETTERS
73 Mechanistic and thermodynamic insights into the deoxygenation of palm oils using Ni2P catalyst: A combined experimental and theoretical study Mechanistic and thermodynamic insights into the deoxygenation of palm oils using Ni2P catalyst: A combined experimental and theoretical study

Deoxygenation (DX) is a key enhancement process for biomass-derived biofuel production. To understand the DX mechanism of palm oils, we performed experimental and computational studies to investigate the DX reaction of palmitic acid on Ni2P catalyst. Experimental characterization and catalytic testing demonstrated that the DX on unsupported (0 0 1)-Ni2P catalyst prefers the decarbonylation (DCO) pathway over the hydrodeoxygenation (HDO) pathway with the ratios between 2.17 and 4.13 to 1. Mechanistic study using density functional theory calculation revealed that the DX of butyric acid also prefers DCO over HDO pathway. Both experimental and computational results suggested that the decarboxylation (DCO2) pathway is unlikely. The computation results indicated that the rate-limiting step of HDO pathway is in the butanol to butane conversion (activation energy E-a = 1.99 eV), whereas that of the DCO pathway is found during the butanal to propane conversion (E-a = 1.52 eV). However, additional thermodynamic analysis accounting for hydrotreating reaction condition (H-2 = 50 bars at 653 K) suggested that the rate-determining step for the DCO pathway is actually the hydrogenation of butyric acid. In addition, the thermodynamics analysis also suggests that increasing reaction temperature may increase selectivity of HDO pathway. The mechanistic insights gained from this study will be beneficial for the enhancement of DX process for biofuel production.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2020-11-01
    ชื่อวารสาร
  • CHEMICAL ENGINEERING JOURNAL
74 Comparison of microwave-assisted and thermal-heated synthesis of P(HEMA-co-AM)/PVA interpenetrating polymer network (IPN) hydrogels for Pb(II) removal from aqueous solution: Characterization, adsorption and kinetic study Comparison of microwave-assisted and thermal-heated synthesis of P(HEMA-co-AM)/PVA interpenetrating polymer network (IPN) hydrogels for Pb(II) removal from aqueous solution: Characterization, adsorption and kinetic study

This work aims to compare the properties and Pb(II) adsorption abilities of the interpenetrating polymer network (IPN) hydrogels of poly(2-hydroxyethyl methacrylate-co-acrylamide)/poly(vinyl alcohol), (P(HEMA-co-AM)/PVA), prepared by microwave-assisted (IPN-MW) and conventionally thermal-heated (IPN-TH) processes for evaluating the suitable and economic method. The results revealed that the microwave-assisted synthesis is not only greatly shorten the reaction time in just 10 min but also markedly improves the porosity and crosslink networks. Consequently, the water swelling (1310%), Young’s modulus (351 MPa) and tensile strength (18.6 MPa) of IPN-MW films were significantly higher than those of IPN-TH film (620%, 224 MPa and 8.4 MPa, respectively). The relationship between Pb(II) adsorption capacity and initial concentration (Co) of IPN-MW and IPN-TH hydrogels showed a good linearity described by; qeq (IPN-MW) (mg/g) = 0.28Co(ppm), R2 = 0.995 and qeq (IPN-TH) (mg/g) = 0.07Co(ppm), R2 = 0.986, respectively. The maximum Pb(II) adsorption capacity on IPN-MW adsorbent (292.5 mg/g) was 4.51 folds higher than IPN-TH hydrogel (64.8 mg/g). The adsorption kinetics on both hydrogels fitted well to the pseudo-first-order kinetics and Freundlich isotherm. The overall results indicate that the microwave-assisted synthesis is a promising and effective method for synthesis of P(HEMA-co-AM)/PVA IPN hydrogel as an effective adsorbent for removing of heavy metal ions in various aqueous solutions.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-01-15
    ชื่อวารสาร
  • European Polymer Journal
75 A portable selective electrochemical sensor amplified with Fe3O4@Au-cysteamine-thymine acetic acid as conductive mediator for determination of mercuric ion A portable selective electrochemical sensor amplified with Fe3O4@Au-cysteamine-thymine acetic acid as conductive mediator for determination of mercuric ion

Mercury ion (Hg2+) is considered to be one of the most toxic heavy metal ions and can cause adverse effects on kidney function, the central nervous system, and the immune system. Therefore, it is important to develop a fast and simple method for sensitive and selective detection of Hg2+ in the environment. This research proposes a portable electrochemical sensor for rapid and selective detection of Hg2+. The sensor platform is designed based on thymine acetic acid anchored with cysteamine-conjugated core shell Fe3O4@Au nanoparticles (Fe3O4@Au/CA/T-COOH) immobilized on a sensing area of a screen-printed carbon electrode (SPCE) with the aid of an external magnetic field embedded in a homemade electrode holder for ease of handling. In the presence of Hg2+, the immobilized thymine combines specifically with Hg2+ and forms a thymine-Hg2+-thymine mismatch (T-Hg2+-T). The resulting amount of Hg2+ was determined by differential pulse anodic stripping voltammetry (DPASV). Under optimal conditions, the sensor exhibited two wide linearities in a range from 1 to 200 μg L−1 and 200–2200 μg L−1 with the reliability coefficient of determination of 0.997 and 0.999, respectively. The detection limit (LOD) and the quantification limit (LOQ) were also determined to be 0.5 μg L−1 and 1.0 μg L−1, respectively. The sensor was further applied for determination of Hg2+ in water samples, a certified reference material and fish samples. The results were compared with flow injection atomic spectroscopy-inductively coupled plasma-optical emission spectroscopy (FIAS-ICP-OES) systems as a reference method. Results obtained with the proposed sensor were relatively satisfactory, and they showed no significant differences at a 95% confidence level by t-test from the standard method. Therefore, considering its fast and simple advantages, this novel strategy provides a potential platform for construction of a Hg2+ electrochemical sensor.

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-01-01
    ชื่อวารสาร
  • Talanta
76 Biodegradable hydrogels of cassava starch-g-polyacrylic acid/natural rubber/polyvinyl alcohol as environmentally friendly and highly efficient coating material for slow-release urea fertilizers Biodegradable hydrogels of cassava starch-g-polyacrylic acid/natural rubber/polyvinyl alcohol as environmentally friendly and highly efficient coating material for slow-release urea fertilizers

Biodegradable semi-IPN hydrogels of cassava starch (CSt)-g-polyacrylic acid (PAA)/natural rubber (NR)/polyvinyl alcohol (PVA) at different NR/PVA ratios were developed as low-cost coating membrane for improving slow-released fertilizer with low negative impact on environments. The effect of NR/PVA ratios on mechanical properties, swelling behavior, water retention and biodegradation of the semi-IPN hydrogels was evaluated. The biodegradable hydrogel wax coated urea (BHWCU) was produced by coating urea particles with semi-IPN hydrogel and wax as inner and outer layers, respectively. Results revealed that the higher NR/PVA ratios caused the significant decrease in water swelling, modulus, water-retention and biodegradation of the hydrogels. The BHWCU/9:1 formulation exhibited an excellent slow-release N nutrient in both water (47.5% at 168 h) and soil (38.5% at 30 day), relating well with the lowest surface area (1.95 m2/g) and pore volume (3.75 × 10−3 cm3/g). The release kinetics of BHWCUs in both water and soil followed the Korsmeyer-Peppas model. The released nutrient from the BHWCU/9:1 was strongly depended on the pH, temperature and ionic strength. The growth of chili plant was effectively facilitated by the BHWCU/9:1 having 4–5 times lower production cost (80.36 Baht/kg) than commercial slow-release fertilizer. Thus, the BHWCU formulations could be extensively applicable in sustainable agriculture.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-09-25
    ชื่อวารสาร
  • Journal of Industrial and Engineering Chemistry
77 Theoretical insights into catalytic CO2 hydrogenation over single-atom (Fe or Ni) incorporated nitrogen-doped graphene Theoretical insights into catalytic CO2 hydrogenation over single-atom (Fe or Ni) incorporated nitrogen-doped graphene

Developing highly efficient and cheap catalysts for the CO2 hydrogenation is the key to achieve CO2 conversion into clean energy. Herein, periodic density functional theory (DFT) calculations are performed to investigate possible reaction mechanisms for the hydrogenation of CO2 to formic acid (cis- or trans-HCOOH) product over a single Fe or Ni atom incorporated nitrogen-doped graphene (Fe-N3Gr or Ni-N3Gr) sheets. Our calculations found that the CO2 hydrogenation proceeds via a coadsorption mechanism to produce cis- or trans-HCOOH over Fe-N3Gr and Ni-N3Gr surfaces, which is classified into 2 steps: (1) the CO2 hydrogenation to form a formate (HCOO*) intermediate and (2) hydrogen abstraction to produce cis- or trans-HCOOH. The formation of trans-HCOOH over both Fe-N3Gr and Ni-N3Gr surfaces exhibit the obvious superiority due to the low barrier all through the whole channel. The highest energy barriers (Ea) in the case of trans-HCOOH formation on Fe-N3Gr and Ni-N3Gr surfaces are only 0.57 and 0.37 eV, respectively, which indicated that the CO2 hydrogenation to trans-HCOOH could be realized over these catalysts at low temperatures, especially the Ni-N3Gr surface. On the other hand, our findings show that the competitive reaction that produces CO and H2O is almost impossible or extremely difficult to proceeds under ambient conditions due to the large Ea for the formation of these side products. Moreover, the microkinetic modeling of the CO2 hydrogenation on both surfaces was investigated to confirm these results. Thus, the Fe-N3Gr and Ni-N3Gr catalysts reveal excellent catalytic activity and highly selective for CO2 hydrogenation to trans-HCOOH. This theoretical investigation not only provides a promising catalyst but also gives a deeper understanding of CO2 hydrogenation reaction.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-06-01
    ชื่อวารสาร
  • Journal of CO2 Utilizatio
    DOI
78 Novel dual-sensor for creatinine and 8-hydroxy-2'-deoxyguanosine using carbon-paste electrode modified with molecularly imprinted polymers and multiple-pulse amperometry Novel dual-sensor for creatinine and 8-hydroxy-2'-deoxyguanosine using carbon-paste electrode modified with molecularly imprinted polymers and multiple-pulse amperometry

We present a novel amperometric dual-imprinted sensor for simultaneous determination of creatinine (Cre) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in human urine and serum. The sensor used multiple-pulse amperometric detection in flow injection analysis (MPA-FIA). Copper oxide nanoparticles were coated with the Cre molecularly-imprinted polymer (CuO@MIP), using methacrylic acid as the functional monomer and N, N′-(1,2-dihydroxyethylene) bis-acrylamide as cross-linker. For 8-OHdG sensing, we embedded platinum nanoparticles in reduced graphene oxide and then coated it with guanosine poly-dopamine MIP (PtNPs-rGO@MIP). A carbon-paste electrode (CPE) was then formed containing both nanocomposites to give the dual MIP sensor (CuO@MIP and PtNPs-rGO@MIP/CPE). We developed a dual-potential waveform as a function of time, with Edet.1 (+0.4 V/150 ms) to determine Cre selectively and Edet.2 (+0.6 V/250 ms) to analyze both compounds simultaneously (Cre and 8-OHdG). Subtracting the two signals at 0.6 V and 0.4 V (using a correction factor), respectively, from each other allowed for quantifying 8-OHdG without interference from Cre. The MIP sensor has a linear range of 0.5–150 μM for creatinine and 0.005–50 μM for 8-OHdG, with limits of detection in nano-molar level. The proposed method is successfully applied for the simultaneous determination of Cre and 8-OHdG in urine and serum samples.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-05-01
    ชื่อวารสาร
  • Sensors and Actuators B: Chemical
79 Metal-doped carbon nanocones as highly efficient catalysts hydrogen storage: Nuclear quantum effect on hydrogen spillover mechanism Metal-doped carbon nanocones as highly efficient catalysts hydrogen storage: Nuclear quantum effect on hydrogen spillover mechanism

We investigated H-spillover mechanisms on Pt atoms decorating defective carbon nanocones (Pt/dCNC) using the multicomponent B3LYP (MC_B3LYP) method, which can take account of the nuclear quantum effect (NQE) of light nuclei. MC_B3LYP shows reduced relative energies for all stationary-point structures and lower energy barriers to H-spillover reactions. Interestingly, MC_B3LYP calculations reveal that the activation energy for H2 dissociation completely vanishes indicating that H2 molecules dissociate readily on Pt/dCNC. Our crucial finding is that the different metal (Pt and Pd) on dCNC surface has affected the thermodynamic favorability of the hydrogen dissociation process, on Pt/dCNC is facile and highly exothermic, while on Pd/dCNC is dramatically endothermic. Furthermore, comparison of combined dissociation-spillover mechanism on Pt decorated on carbon nanocone (Pt/dCNC) and Pt decorated on graphene (Pt/dG) catalysts have been focused to explain the curvature effect which can facilitate the hydrogen spillover process and provide a highly exothermic reaction, which is more thermodynamically favorable than that of a metal-graphene surface. Our new understanding of this reaction mechanism and the influence of NQEs on electronic properties will be useful for the future development of the spillover mechanism as well as the synthesis of high-performance Pt/dCNC for H2 energy applications.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-03-01
    ชื่อวารสาร
  • Molecular Catalysis
80 Mimicking Peroxidase-Like Activity of Nitrogen-Doped Carbon Dots (N-CDs) Coupled with a Laminated Three-Dimensional Microfluidic Paper-Based Analytical Device (Laminated 3D-μPAD) for Smart Sensing of Total Cholesterol from Whole Blood Mimicking Peroxidase-Like Activity of Nitrogen-Doped Carbon Dots (N-CDs) Coupled with a Laminated Three-Dimensional Microfluidic Paper-Based Analytical Device (Laminated 3D-μPAD) for Smart Sensing of Total Cholesterol from Whole Blood

This work presents a simple hydrothermal synthesis of nitrogen-doped carbon dots (N-CDs), fabrication of microfluidic paper-based analytical device (μPAD), and their joint application for colorimetric determination of total cholesterol (TC) in human blood. The N-CDs were characterized by various techniques including transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray powder diffraction (XRD), and the optical and electronic properties of computational models were studied using the time-dependent density functional theory (TD-DFT). The characterization results confirmed the successful doping of nitrogen on the surface of carbon dots. The N-CDs exhibited high affinity toward 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)-diammonium salt (ABTS) with the Michaelis–Menten constant (KM) of 0.018 mM in a test for their peroxidase-like activity. Particularly, since hydrogen peroxide (H2O2) is the oxidative product of cholesterol in the presence of cholesterol oxidase, a sensitive and selective method of cholesterol detection was developed. Overall, the obtained results from TD-DFT confirm the strong adsorption of H2O2 on the graphitic N positions of the N-CDs. The laminated three-dimensional (3D)-μPAD featuring a 6 mm circular detection zone was fabricated using a simple wax screen printing technique. Classification of TC according to the clinically relevant criteria (healthy, <5.2 mM; borderline, 5.2–6.2 mM; and high risk, >6.2 mM) could be determined by the naked eye within 10 min by simple comparison using a color chart. Overall, the proposed colorimetric device serves as a low-cost, rapid, simple, sensitive, and selective alternative for TC detection in whole blood samples that is friendly to unskilled end users.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-04-18
    ชื่อวารสาร
  • Analytical Chemistry
81 Microstructural characterization of white charcoal for rapid reduction of chemical oxygen demand and automatically adjust pH to neutral in wastewater treatment Microstructural characterization of white charcoal for rapid reduction of chemical oxygen demand and automatically adjust pH to neutral in wastewater treatment

The purpose of this study was to produce, characterize and apply white and black charcoal for wastewater treatment application. Characterization of charcoals, the results confirmed that white charcoal had higher thermal stability and carbon content than black charcoal. The other elemental analysis results showed that both black and white charcoal show the highest intensity of potassium content. The surface of black charcoal was rougher than the surface of white charcoal. The morphology from scanning electron microscope coupled with Energy Dispersive X-ray Spectrophotometer (SEM-EDS) images demonstrated white charcoal shows a highly porous material, especially coconut shell white charcoal with small holes connected to large holes. X-ray diffraction patterns (XRD) showed peak patterns of graphite. The specific surface area, total pore volume, and pore size of all charcoal were evaluated by the BET method. This result was a higher specific surface area of white charcoal than black charcoal. The coconut shell white charcoal had the highest specific surface area (458.80 m 2/g). All charcoals had an average pore size in the range from 1 to 2 nm, all charcoals had an average pore size in the range from 1 to 2 nm which was microporous materials. Both black and white charcoal were used as an adsorbent for the wastewater treatment from a chemistry laboratory building. The results indicated that white charcoal could neutralize the pH of wastewater after treatment in both acidity and alkalinity wastewater. After treatment, wastewater treated with white charcoal shows a higher level of %COD reduction than wastewater treated with black charcoal.

นุชนาพร พิจารณ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-07-01
    ชื่อวารสาร
  • Journal of Materials Research and Technology
82 In situ self-assembled coating of surfactant-mixed metal hydroxide on Fe3O4@SiO2 magnetic composite for dispersive solid phase microextraction prior to HPLC analysis of triazole fungicides In situ self-assembled coating of surfactant-mixed metal hydroxide on Fe3O4@SiO2 magnetic composite for dispersive solid phase microextraction prior to HPLC analysis of triazole fungicides

A new approach for the determination of five triazole fungicides, i.e. triadimefon, flusilazole, tebuconazole, penconazole and propiconazole, in water samples has been developed. The developed method was based on a self-assembled coating of surfactant-mixed metal hydroxide on Fe3O4@SiO2 magnetic composite. The resulting coated nanocomposite was directly used as an efficient sorbent in dispersive solid phase microextraction of the triazole fungicides. As an in-situ process, surface modification of the sorbent and extraction of the triazole fungicides were accomplished together. Also, the combined unique properties of the composite sorbent exhibited superior performance in terms of high separation and extraction efficiency. After the studied extraction, the extracted triazole fungicides were separated and quantified using high performance liquid chromatographic analysis. The parameters for the optimum extraction condition were 100 mL sample volume, 20 mg of Fe3O4@SiO2 sorbent, 10 mg of sodium dodecyl sulfate, 0.738 g of Mg(NO3)2, 0.36 g of Al(NO3)3, 1 g of NaCl, pH 10, 10 min of extraction time and 6 mL of acetonitrile as desorption solvent. Under the optimized condition, the linearity was obtained in the range of 5–100 µg L−1 for triadimefon and 2.5–50 µg L−1 for flusilazole, tebuconazole, penconazole and propiconazole. The obtained limits of detection were 1.0–2.5 μg L−1. High precision (the intra–day and inter–day precision) was achieved with the relative standard deviation of less than 8%. The enhancement factors ranged from 40 to 237. The proposed extraction was successfully applied for the analysis of the triazole fungicides in water samples with good recovery in the range of 90–104%.

เกษริน สีบุญเรือง Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-05-13
    ชื่อวารสาร
  • Microchemical Journal
83 Formic acid dehydrogenation over single atom Pd-deposited carbon nanocones for hydrogen production: a mechanistic DFT study Formic acid dehydrogenation over single atom Pd-deposited carbon nanocones for hydrogen production: a mechanistic DFT study

A single palladium (Pd) atom embedded in a high curvature defective carbon nanocone (Pd/dCNC) is investigated for formic acid (FA) decompositions using DFT calculations. We used Pd/dCNC as the catalyst for either trans-FA or cis-FA decomposition. FA is stably adsorbed on Pd/dCNC with very high adsorption energy compared to the Pd/dG surface. For the reaction mechanisms, the preferable FA dehydrogenation mechanisms proceed via the formate pathway, with a rate-determining step of only 0.50 eV (trans-FA) and 0.54 eV (cis-FA), which are less than that on active Pd (111) catalysts. The rate of hydrogen (H2) production is dependent on the FA concentration. The active neighboring C atom plays a significant role in facilitating FA dehydrogenation into H2. The side reaction producing CO and H2O via the formyl or carboxyl pathway cannot occur on Pd/dCNC due to a high energy-barrier and low production rate obtained by microkinetic simulations. Thus, our proposed catalysts effectively provide excellent activity and selectivity for FA dehydrogenation into H2.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-06-10
    ชื่อวารสาร
  • Molecular Systems Design & Engineering
84 Theoretical insights into catalytic CO2 hydrogenation over single-atom (Fe or Ni) incorporated nitrogen-doped graphene Theoretical insights into catalytic CO2 hydrogenation over single-atom (Fe or Ni) incorporated nitrogen-doped graphene

Developing highly efficient and cheap catalysts for the CO2 hydrogenation is the key to achieve CO2 conversion into clean energy. Herein, periodic density functional theory (DFT) calculations are performed to investigate possible reaction mechanisms for the hydrogenation of CO2 to formic acid (cis- or trans-HCOOH) product over a single Fe or Ni atom incorporated nitrogen-doped graphene (Fe-N3Gr or Ni-N3Gr) sheets. Our calculations found that the CO2 hydrogenation proceeds via a coadsorption mechanism to produce cis- or trans-HCOOH over FeN3Gr and Ni-N3Gr surfaces, which is classified into 2 steps: (1) the CO2 hydrogenation to form a formate (HCOO*) intermediate and (2) hydrogen abstraction to produce cis- or trans-HCOOH. The formation of transHCOOH over both Fe-N3Gr and Ni-N3Gr surfaces exhibit the obvious superiority due to the low barrier all through the whole channel. The highest energy barriers (Ea) in the case of trans-HCOOH formation on Fe-N3Gr and Ni-N3Gr surfaces are only 0.57 and 0.37 eV, respectively, which indicated that the CO2 hydrogenation to trans-HCOOH could be realized over these catalysts at low temperatures, especially the Ni-N3Gr surface. On the other hand, our findings show that the competitive reaction that produces CO and H2O is almost impossible or extremely difficult to proceeds under ambient conditions due to the large Ea for the formation of these side products. Moreover, the microkinetic modeling of the CO2 hydrogenation on both surfaces was investigated to confirm these results. Thus, the Fe-N3Gr and Ni-N3Gr catalysts reveal excellent catalytic activity and highly selective for CO2 hydrogenation to trans-HCOOH. This theoretical investigation not only provides a promising catalyst but also gives a deeper understanding of CO2 hydrogenation reaction.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-06-01
    ชื่อวารสาร
  • JOURNAL OF CO2 UTILIZATION
85 Mechanistic insight into catalytic carbon dioxide hydrogenation to formic acid over Pt-doped boron nitride nanosheets Mechanistic insight into catalytic carbon dioxide hydrogenation to formic acid over Pt-doped boron nitride nanosheets

In this work, we investigated the mechanism of CO2 hydrogenation over the Pt-doped boron nitride nanosheets (Pt-BNNSs) by using the density functional theory (DFT). It is found that a Pt adatom can be effectively stabilized in boron vacancy site (Pt-BV). Our investigation shows that the reaction mechanisms of CO2 hydrogenation over Pt-BV can be found in three possible reaction pathways: (i) co-adsorption, (ii) H2 dissociation, and (iii) co-adsorption together with H2 dissociation pathways. The co-adsorption together with H2 dissociation provides the most favorable pathway among of these three proposed mechanisms. The important finding of our study is that the presence of CO2 in step of hydrogen dissociation plays an important role in producing the FA on the Pt-BV catalyst. Moreover, we found that the hydrogenation of CO2 via carboxylate (COOH) has the rate-determining step of 0.63 eV in the step of hydrogen dissociation. In addition, the microkinetic modelling suggests that the COOH route is found to be more energetically and kinetically feasible rather than that it is formate route (HCOO) with the reaction temperature at 350 K and pressure of 5 bar. Our calculation results provide an important information for developing Pt-BV catalysts and might shed light on experimental design the novel Pt-BV catalyst for the CO2 hydrogenation and the conversion of greenhouse gases into value-added products.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-06-01
    ชื่อวารสาร
  • Molecular Catalysis
86 Use of nitrogen-doped amorphous carbon nanodots (N-CNDs) as a fluorometric paper-based sensor: a new approach for sensitive determination of lead(II) at a trace level in highly ionic matrices Use of nitrogen-doped amorphous carbon nanodots (N-CNDs) as a fluorometric paper-based sensor: a new approach for sensitive determination of lead(II) at a trace level in highly ionic matrices

This work reports a facile synthesis of nitrogen-doped amorphous carbon nanodots (N-CNDs) and their use as a fluorometric paper-based sensor for the determination of Pb2+ at a low concentration. Both solution-based and paper-based systems were developed. The results show that the linearity ranges for Pb2+ determination were 0.010–10 mg L−1 (LOD = 0.008 mg L−1) and 0.005–0.075 mg L−1 (LOD = 0.004 mg L−1) for the solution-based and the paper-based sensors, respectively. Furthermore, the developed sensors show relatively high selectivity toward Pb2+ over ten other metal cations of different charges including As3+, Hg2+, Cd2+, Mg2+, Ni2+, Zn2+, Fe3+, Cu2+, Ba2+, and Ag+. The mechanism of Pb2+ determination was also investigated. It was found that the sensors exploited the quenching of the fluorescence intensity of N-CNDs by Pb2+via the photo-induced electron transfer (PET) mechanism. When applied to real water and herbal medicine samples, the performance of the sensor exhibited no significant difference as compared to the results of the validation method (ICP-OES). Overall, the developed sensors, especially the paper-based one, are promising for the practical analysis of Pb2+ in pharmaceutical and environmental samples with a low Pb2+ concentration.

ปุริม จารุจำรัส Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-08-01
    ชื่อวารสาร
  • Analytical Methods
87 Ionic liquids for high performance lithium metal batteries Ionic liquids for high performance lithium metal batteries

The pursuit of high energy density has promoted the development of high-performance lithium metal batteries. However, it faces a serious security problem. Ionic liquids have attracted great attention due to their high ionic conductivity, non-flammability, and the properties of promoting the formation of stable SEI films. Deeply understanding the problems existing in lithium metal batteries and the role of ionic liquids in them is of great significance for improving the performance of lithium metal batteries. This article reviews the effects of the molecular structure of ionic liquids on ionic conductivity, Li+ ion transference number, electrochemical stability window, and lithium metal anode/electrolyte interface, as well as the application of ionic liquids in Li-high voltage cathode batteries, Li-O2 batteries and Li-S batteries. The molecular design, composition and polymerization will be the main strategies for the future development of ionic liquid-based electrolytes for high performance lithium metal battery.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-08-01
    ชื่อวารสาร
  • Journal of Energy Chemistry
88 Ti4-Decorated B/N-doped graphene as a high-capacity hydrogen storage material: A DFT study Ti4-Decorated B/N-doped graphene as a high-capacity hydrogen storage material: A DFT study

The adsorption properties of the hydrogen atom on our newly designed materials were investigated using density functional theory (DFT) calculations, focusing on the role of dopants in modulating the binding properties of the metal. We proposed decorating Ti4 on pristine, B- and N-doped graphene surfaces for preparing a large-capacity hydrogen-storage device. Computational results indicate that the doping of B on graphene enhances the interaction between the metal cluster and the supporting substrate with a very strong binding energy of −6.45 eV, which is the strongest interaction among our proposed catalysts. This binding energy prevents the aggregation and formation of Ti–metal clusters. Dissociative chemisorption of the first H2 molecule occurs on all materials. Metal hydrides preferentially exhibit strong hybridization between the H-1s and Ti-3d orbitals. Furthermore, Ti4 decorated B-graphene is the most effective, with a high capacity of hydrogen adsorption which could be released under practical conditions. We confirmed that eight H2 molecules could stably adsorb on Ti4/BGr with six reversible hydrogen adsorptions. Our proposed B-doped graphene-based material, Ti4/BGr, offers high cluster-stability on the substrate with high-capacity hydrogen storage compared to various other surfaces in the previous work. Therefore, Ti4 decorated B-graphene is a promising candidate material for use as a reversible hydrogen storage material.  

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-07-01
    ชื่อวารสาร
  • Dalton Transactions
89 Antibacterial and Antifungal Polyketides from the Fungus Aspergillus unguis PSU-MF16 Antibacterial and Antifungal Polyketides from the Fungus Aspergillus unguis PSU-MF16

Seven new polyketides including a phenol (1), two diphenyl ethers (2 and 3), two depsidones (4 and 5), and two phthalides (6 and 7) were isolated from the fungus Aspergillus unguis PSU-MF16 along with 27 known compounds. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of 1 and 4–7 were established using comparative analyses of calculated and experimental ECD spectra. Among the new metabolites, 2 exhibited the best antimicrobial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and Microsporum gypseum with equal MIC values of 16 μg/mL. In addition, known emeguisin A displayed potent antimicrobial activity against S. aureus, methicillin-resistant S. aureus, and Cryptococcus neoformans with equal MIC values of 0.5 μg/mL, compared with the standard drugs, vancomycin and amphotericin B. The structure–activity relationship study of the isolated compounds for antimicrobial activity is discussed.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-04-16
    ชื่อวารสาร
  • Journal of Natural Products
90 0 0

We report a novel three-dimensional microfluidic paper-based analytical device (3D-μPAD) with colorimetric detection, using Mn–ZnS quantum dot embedded molecularly imprinted polymer (Mn–ZnS QD-MIP), for selective glyphosate determination in whole grain samples. Detection is based on the catalytic activity of Mn–ZnS QD-MIP in the H2O2 oxidation of ABTS. Glyphosate imprinted polymer is successfully synthesized on the Mn–ZnS QD surface using a poly (N-isopropylacrylamide) (NIPAM) and N, N′-Methylenebisacrylamide (MBA) as the functional monomers. The catalytic activity depends on binding or non-binding of glyphosate molecules on the synthetic recognition sites of the Mn–ZnS QD-MIP. Glyphosate selectively binds to the cavities embedded on the Mn–ZnS QD surface, and subsequently turns-off or inhibits the ABTS oxidation and color change to light green. The change of reaction color from dark green to light green depends on the concentration of glyphosate. We report, for the first time, using the relatively new penguard enamel colour to create a hydrophobic barrier. The foldable 3D-μPAD comprises three layers (top/center/bottom), named as the detection zone, immobilized Mn–ZnS QD-MIP disc, and sample loading. Assay on the 3D-μPAD can determine glyphosate by ImageJ detection, over an operating range of 0.005–50 μg mL−1 and with a detection limit of 0.002 μg mL−1. Our 3D-μPAD exhibits high accuracy, with a 0.4% (intra-day) and 0.7% (inter-day) relative difference from the certified CRM value. Moreover, the fabricated 3D-μPAD provides good reproducibility (1.7% RSD for ten devices). The developed 3D-μPAD was successfully applied to determine the glyphosate concentration in whole grain samples and shows great promise as an alternative highly selective and sensitive colorimetric method. The 3D-μPAD is well suited to food-quality control and onsite environmental-monitoring applications, without sophisticated instrumentation.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-04-01
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  • Talanta
91 Conjugated Copolymers That Shouldn't Be Conjugated Copolymers That Shouldn't Be

Multiple studies have explored using cage silsesquioxanes (SQs) as backbone elements in hybrid polymers motivated by their well-defined structures and physical and mechanical properties. As part of this general exploration, we report unexpected photophysical properties of copolymers derived from divinyl double decker (DD) SQs, [vinyl(Me)Si(O0.5)2][PhSiO1.5]8[(O0.5)2Si(Me)vinyl] (vinylDDvinyl). These copolymers exhibit strong emission red-shifts relative to model compounds, implying unconventional conjugation, despite vinyl(Me)Si(O-)2 siloxane bridges. In an effort to identify minimum SQ structures that do/do not offer extended conjugation, we explored Heck catalyzed co-polymerization of vinyl-ladder(LL)-vinyl compounds, vinyl(Me/Ph)Si(O0.5)2[PhSiO1.5]4(O0.5)2Si(Me/Ph)vinyl, with Br-Ar-Br. Most surprising, the resulting oligomers show 30–60 nm emission red-shifts beyond those seen with vinylDDvinyl analogs despite lacking a true cage. Further evidence for unconventional conjugation includes apparent integer charge transfer (ICT) between LL-co-thiophene, bithiophene, and thienothiophene with 10 mol % F4TCNQ, suggesting potential as p-type doped organic/inorganic semiconductors.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-02-25
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  • Angewandte Chemie - International Edition
92 Composite proton conducting membranes from chitosan, poly(vinyl alcohol) and sulfonic acid-functionalized silica nanoparticles Composite proton conducting membranes from chitosan, poly(vinyl alcohol) and sulfonic acid-functionalized silica nanoparticles

Composite proton conducting membranes were successfully synthesized from chitosan, poly (vinyl alcohol) and sulfonic acid-functionalized silica nanoparticles. Sulfosuccinic acid (SSA) and glutaraldehyde were used as double crosslinking agents, where the effect of SSA content on membrane properties, including water vapor absorption, water uptake, ion exchange capacity, and proton conductivity was investigated and were found to increase as a function of SSA loading. The most promising membrane was then formed into a composite with either silica nanoparticles containing poly (2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS-Si) or poly (styrene sulfonic acid) (PSSA-Si). PAMPS-Si and PSSA-Si were characterized by thermogravimetric analysis (TGA), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The effects of nanoparticle loading and polymer shell on membrane properties were studied. Proton conductivity increased at higher nanoparticle loadings, and reached a maximum of 3.8–3.9 × 10−3 S/cm at 20% loading. The influence of polymer shell on membrane properties was not significantly observed.

ประนอม แซ่จึง Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-01-06
    ชื่อวารสาร
  • International Journal of Hydrogen Energy
93 Rational design of anthracene-based deep-blue emissive materials for highly efficient deep-blue organic light-emitting diodes with CIEy ≤ 0.05 Rational design of anthracene-based deep-blue emissive materials for highly efficient deep-blue organic light-emitting diodes with CIEy ≤ 0.05

By using molecular twisting 2,2′-dimethylbiphenyl core and different side group substitutions, three anthracene-based deep blue emitters, 10,10'-(2,2′-dimethyl-[1,1′-biphenyl]-4,4′-diyl)bis(9-phenylanthracene) (PABP), 10,10'-(2,2′-dimethyl-[1,1′-biphenyl]-4,4′-diyl)bis(9-(naphthalen-2-yl)anthracene) (βNABP) and 10,10'-(2,2′-dimethyl-[1,1′-biphenyl]-4,4′-diyl)bis(9-(naphthalen-1-yl)anthracene) (αNABP), were effectively developed. These three twisted anthracene derivatives exhibited strong deep blue photoluminescence which remarkably surpassed the standard blue for the high-definition television (HDTV). Particularly, PABP with high hole mobility of 1.67 × 10−5 cm2 V−1 s−1 delivered a high OLED device performance with external quantum efficiency (EQE) of 4.04% and deep blue emission colour with CIE coordinates of (0.15, 0.05).

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-01-01
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  • Dyes and Pigments
94 Oxygen-deficient bismuth molybdate nanocatalysts: Synergistic effects in boosting photocatalytic oxidative coupling of benzylamine and mechanistic insigt Oxygen-deficient bismuth molybdate nanocatalysts: Synergistic effects in boosting photocatalytic oxidative coupling of benzylamine and mechanistic insigt

Herein, bismuth molybdate (Bi2MoO6) nanocatalysts containing oxygen vacancies (OVs) are found to considerably promote the photocatalytic performance toward oxidative coupling of benzylamine to N-benzylidenebenzylamine under visible light irradiation. The structure-activity relationship for this interesting catalyst is revealed for the first time. The oxygen-deficient Bi2MoO6 nanoplatelets (BMO-NPs) are synthesized using ethylene glycol-ethanol solvent mixture as a reaction medium in solvothermal method. A comparison with hydrothermally prepared Bi2MoO6 square-like sheets (BMO-SHs) suggests that the nanoplatelets are much smaller in size and contain higher amount of OVs. Benzylamine conversion over the BMO-NPs is ca. 4.0 times higher than that over the BMO-SHs and ca. 3.8 and ca. 34.6 times higher than that over the commercial benchmark TiO2 P25 and BiVO4 catalysts, respectively. The BMO-NPs achieve more than 80% product yield within 2 h of irradiation regardless of substituents of benzylamine derivatives. The enhanced activity of BMO-NPs is due to synergistic roles of high surface-to-volume ratio and OVs, providing enlarged active area, extended light absorption range and improved charge separation and transfer efficiency as evidenced from UV–vis DRS, BET surface area, photocurrent response, electrochemical impedance spectroscopy, and time-resolved fluorescence decay measurements. EPR-trapping and radical scavenging experiments indicate O2− as a main active species rather than 1O2 and a plausible imine formation mechanism via O2−-assisted charge transfer is proposed accordingly. The work offers an alternative facile preparation method to design efficient semiconductor photocatalysts and for the first time reveals a possible benzylamine coupling mechanism over the oxygen-deficient Bi2MoO6 nanocatalyst.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-01-01
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  • Journal of Colloid and Interface Science
95 Enhancement of the electroluminescence properties of iridium-complexes by decorating the ligand with hole-transporting carbazole dendrons Enhancement of the electroluminescence properties of iridium-complexes by decorating the ligand with hole-transporting carbazole dendrons

Iridium complexes are particularly essential and have been intensively utilized as emissive phosphorescence emitters for efficient phosphorescent electroluminescent (EL) devices. In order to improve the EL performance, a series of new iridium complexes decorated with carbazole dendrons in a non-conjugated fashion using an ether linkage were designed and synthesized. The iridium(III) bis(4-methyl-2-phenylpyridinato-N,C2′)picolinate substituted with a hexyl chain (IrG0), N-hexyl carbazole (IrG1), N-hexyl-N′-9,3′:6′,N′′-tercarbazole (IrG2) and N-hexyl-6′,6′′′-di(carbazol-N-yl)-N′′,3′:N′,3′′:6′′,N′′′:3′′′,N′′′′-quinquecarbazole (IrG3) was designed to afford improved hole-transporting properties without affecting the iridium core's photophysical and electronic properties. The synthesized iridium complexes exhibited intense yellowish-green photoluminescence (PL) emissions at 542–561 nm in the film state. The hole-transporting capability of the complexes was found to be improved when carbazole dendrons were incorporated in the ligand and increased as the generation of the substituent carbazole dendrons increased in the order of IrG0 < IrG1 < IrG2 < IrG3. In particular, the use of IrG3, showing the highest hole mobility, in an organic light-emitting diode (OLED) device resulted in a strong and stable green emission peaking at 532 nm (color coordinates CIE x, y of (0.36, 0.56)) with a brightness of 16 170 cd m−2, the maximum luminous efficiency of 13.59 cd A−1 and a maximum EQE of 4.36%.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-01-22
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  • New Journal of Chemistry
96 Antimicrobial electrospun nanofiber mats of NaOH-hydrolyzed chitosan (HCS)/PVP/PVA incorporated with in-situ synthesized AgNPs: Fabrication, characterization, and antibacterial activity Antimicrobial electrospun nanofiber mats of NaOH-hydrolyzed chitosan (HCS)/PVP/PVA incorporated with in-situ synthesized AgNPs: Fabrication, characterization, and antibacterial activity

This work aims to improve the electrospinability and antibacterial activity of chitosan (CS) - based nanofibers. Three approaches consisting of reducing molecular weight of CS by NaOH hydrolysis (HCS), blending with two carrying polymers (polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA)) and incorporating with in-situ synthesized silver nanoparticles (AgNPs) were integrated simultaneously for the first time to fabricate the HCS-AgNPs/PVP/PVA multicomponent nanofibers. The electrospinning parameters were optimized to obtain the smooth and uniform nanofibers without beads of both HCS/PVP/PVA and HCS-AgNPs/PVP/PVA systems. The presence of in-situ AgNPs in the multicomponent blends gives the better electrospinning performance and the lowest fiber diameter of 139 nm. In addition, the thermal properties, thermal stability and crystallinity index of both nanofibers also increased with increasing HCS or HCS-AgNPs fractions. Finally, the best antibacterial activity of HCS/PVP/PVA and HCS-AgNPs/PVP/PVA nanofibers against E. coli was found to be 74.4% and 99.9%, respectively. The significant enhancement in bactericidal activity of HCS-AgNPs/PVP/PVA nanofibers against E. coli is due to the synergistic properties of HCS/PVP/PVA blends and AgNPs. Both nanofiber mats displayed the excellent structural stability in moisture environment for at least 7 days. Therefore, the HCS-AgNPs/PVP/PVA nanofibers could be a potential material for applying in the medical purpose.

สายันต์ แสงสุวรรณ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-11-01
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  • International Journal of Biological Macromolecules
97 0 0

A new fluorescence probe based on [5]helicene derivative (MT) was designed and synthesized. The chemical structure of the probe was fully characterized by NMR, mass spectrometry and X-ray crystallography. MT which is the combination of thioamide[5]helicene with Schiff base-thiophene moiety, exhibited a high selectivity to detect Hg2+ through irreversible desulfurization reaction with “TurnON” fluorescence response and large Stokes shift of 110 nm in aqueous methanol solution. The detection limit of MT was 1.2 ppb (6.0 × 10−3 µM), which is lower than the limit of Hg2+ level in drinking water, as specified by WHO (6.0 ppb) and U.S. EPA (2.0 ppb). The Hg2+ detection range of the probe was 0.07–1.6 µM with good linearity. Under UV irradiation, MT possessed the capability to detect Hg2+ in diverse context of real samples, including drinking and sea waters, vegetable tissue and brain tumor cell. In addition, MT could be used as a paper test strip for monitoring and screening of Hg2+ contamination in environment.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-09-15
    ชื่อวารสาร
  • Journal of Hazardous Materials
98 Enzymatic electrochemical biosensor for glyphosate detection based on acid phosphatase inhibition Enzymatic electrochemical biosensor for glyphosate detection based on acid phosphatase inhibition

A novel enzymatic electrochemical biosensor was fabricated for the indirect detection of glyphosate-based acid phosphatase inhibition. The biosensor was constructed on a screen-printed carbon electrode modified with silver nanoparticles, decorated with electrochemically reduced graphene oxide, and chemically immobilized with acid phosphatase via glutaraldehyde cross-linking. We measured the oxidation current by chronoamperometry. The current arose from the enzymatic reaction of acid phosphatase and the enzyme-substrate disodium phenyl phosphate. The biosensing response is a decrease in signal resulting from inhibition of acid phosphatase in the presence of glyphosate inhibitor. The inhibition of acid phosphatase by glyphosate was investigated as a reversible competitive-type reaction based on the Lineweaver-Burk equation. Computational docking confirmed that glyphosate was the inhibitor bound in the substrate-binding pocket of acid phosphatase and that it was able to inhibit the enzyme efficiently. Additionally, the established method was applied to the selective analysis of glyphosate in actual samples with satisfactory results following a standard method.

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-07-27
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  • Analytical and Bioanalytical Chemistry
99 Precisely controlled delivery of plant hormone using poly(vinyl alcohol)/zeolite A hydrofilm composite Precisely controlled delivery of plant hormone using poly(vinyl alcohol)/zeolite A hydrofilm composite

Programmable release of a plant hormone, 1-naphthylacetic acid (NAA), could be achieved by using a novel zeolite–hydrofilm (ZHF) composite. The ZHF was prepared using poly(vinyl alcohol) and glutaraldehyde as a cross-linking agent with the addition of different amounts of zeolite A (0, 1.5, 2.0, 2.5, and 3.0 wt%). This reveals that ZHF was formed as a phase-separated microcomposite with chemical interactions between zeolite A and polymer matrix. We found that the composite film with 2.5 wt% zeolite A had the largest pore size, which exhibited the highest water absorbency and the longest water retention time of over 7 h with high thermal and mechanical stabilities. Release profile displayed rapid desorption of NAA from the film at the initial stage, followed by sustained release thereafter. This behavior was explained by the Korsmeyer–Peppas model with a predominant mechanism of simple Fickian diffusion. Additionally, ZHF with NAA could effectively enhance adventitious root formation of Ocimum basilicum Linn. (sweet basil) cuttings due to accurate releasing NAA and time duration for releasing plant hormone. Finally, the NAA released at the film surface could be in a controlled manner with less negative impact on plant and environment.

มาลี ประจวบสุข Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-07-12
    ชื่อวารสาร
  • Polymer Engineering and Science
100 Cytotoxicity and nitric oxide production inhibitory activities of compounds isolated from the plant pathogenic fungus curvularia sp Cytotoxicity and nitric oxide production inhibitory activities of compounds isolated from the plant pathogenic fungus curvularia sp

Chemical investigation of the mycelia of the pathogenic fungus Curvularia sp. which was isolated from a leaf of Dactyloctenium aegyptium (crowfoot grass), resulted in the isolation of a new compound, curvulariahawadride (5), along with five known compounds (1–4, and 6). Their structures were determined on the basis of spectroscopic data, including 1D and 2D NMR and HRESIMS. The absolute configuration of 5 was established from experimental and calculated electronic circular dichroism (ECD). Compounds 1, 3, and 5 showed nitric oxide (NO) production inhibitory activity with IC50 values of 53.7, 32.8, and 12.8 µM, respectively. Compounds 2 and 4 showed significant cytotoxicity against lung cancer A549, colorectal cancer SW480, and leukemic K562 cells with an IC50 ranging value of 11.73 to 17.59 µM.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-05-22
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  • Journal of Fungi
101 Enhanced catalytic activity in hydrogen production from hydrolysis of sodium borohydride using starch hydrogel-CoNi bimetallic alloys Enhanced catalytic activity in hydrogen production from hydrolysis of sodium borohydride using starch hydrogel-CoNi bimetallic alloys

In this article, starch hydrogel was successfully prepared using a citric acid cross-linking method and was used as a template to synthesize starch hydrogel-CoNi bimetallic alloys by the in situ reduction in Co2+ Ni2+ ions using NaBH4 as the reducing agent in the presence of the starch hydrogel network. The starch hydrogel-CoNi bimetallic alloys were simply isolated by filtration and also characterized by SEM, TEM, TGA, FTIR and XRD, respectively. The catalytic activity of starch hydrogel-CoNi bimetallic alloys was used as a catalyst in the hydrogen production from the hydrolysis of NaBH4 in the presence of alkaline solution. The variables affecting on the hydrolysis of NaBH4 such as the initial CoNi molar ratio, initial NaOH concentration, catalyst amount, initial NaBH4 concentration and reaction temperature were examined. The activation energy (Ea), the activation enthalpy (∆H#) and the activation entropy (∆S#) were found to be 36.24 kJ mol−1, 37.75 kJ mol−1 and − 125.23 kJ mol−1 K−1, respectively. The catalyst can be used up to 5 times with 100% conversion, and the catalyst was remained 68% activity after storing 15 days. This approach offers a great potential to utilize starch hydrogel acting as a biocompatible material for a large-scale synthesis of bimetallic alloys for various applications in catalysis.

เสนอ ชัยรัมย์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-03-01
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  • Journal of the Iranian Chemical Society volume
102 Intrinsic property and catalytic performance of single and double metal atoms incorporated g-C3N4 for O2 activation: A DFT insight Intrinsic property and catalytic performance of single and double metal atoms incorporated g-C3N4 for O2 activation: A DFT insight

The intrinsic properties and catalytic performances of single- and double-transition metals on graphitic carbon nitride, TMn@g-C3N4 (n = 1,2), toward the O2 activation were investigated by DFT calculation. The 3d-TM atoms are firmly trapped inside g-C3N4 which prevents the metal clustering and shows high thermodynamic stability. The dimetal-dioxygen adsorption configuration of the O2/TM2@g-C3N4 promotes electron transfer from catalyst to the adsorbed O2, which improves their catalytic performances over the O2/TM@g-C3N4. We observed the two different electron transfer mechanisms for O2 activation on TMn@g-C3N4, in which the double-metal acts as an electron donor while the single-metal acts as the bridge for electron transfer from the substrate to the adsorbed O2. Remarkably, the catalytic performance of the TMn@g-C3N4 for O2 dissociation has a strong correlation with the three factors, (i) the charge gained on adsorbed O2, (ii) the O2 adsorption energy, and (iii) the O-O distance. The Fe2@g-C3N4 as a low-cost and non-precious metal catalyst shows the best catalytic performance with the lowest activation energy barrier of 0.26 eV for O2 activation, and therefore, is predicted as a potential catalyst for O2 consuming reactions. Our finding provides useful information for further design and development of high efficient few-atom catalysts based 2D-carbon materials.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-03-01
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  • Applied Surface Science
103 Effect of the mode of fixation of the thienyl rings on the electronic properties of electron acceptors based on indacenodithiophene (IDT) Effect of the mode of fixation of the thienyl rings on the electronic properties of electron acceptors based on indacenodithiophene (IDT)

Indacenodithiophene (IDT) is a major building block for the design of advanced functional π-conjugated polymers and nonfullerene electron-acceptor materials for organic photovoltaics. Preliminary results of a synthetic approach aiming at the modulation of the electronic properties of IDT-based acceptors by modification of the mode of linkage of the thiophene rings with the median phenyl ring are presented. The synthesis of three acceptor-donor-acceptor (A-D-A) structures corresponding to the different possible modes of thiophene-phenyl connection (1–3) is described and their electronic properties are discussed on the basis of the results of UV–Vis absorption spectroscopy, cyclic voltammetry and theoretical calculations.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-03-01
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  • Dyes and Pigments
104 New Pyrrolobenzoxazine Sesquiterpenoid Derivatives from the Fungus Talaromyces trachyspermus New Pyrrolobenzoxazine Sesquiterpenoid Derivatives from the Fungus Talaromyces trachyspermus

Three new pyrrolobenzoxazine sesquiterpenoids, talatrachyoxazines A – C (1 – 3), together with fourteen known compounds (4 – 17), were isolated from the fungus Talaromyces trachyspermus EU23. Their structures were identified by spectroscopic evidence and mass spectrometry. The absolute configurations of 1 – 3 were determined by NOESY data and comparison of their calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 showed cytotoxic activity against HelaS3, KB, HT-29, MCF-7, and HepG2 cell lines with IC50 values of 7, 11, 10, 12, and 10 µM, respectively. Compounds 1 and 14 showed weak antibacterial activity against the gram-positive bacteria Bacillus cereus and Bacillus subtilis, while 1 – 3 and 14 showed weak antibacterial activity against the gram-negative bacterium Pseudomonas aeruginosa. In addition, compound 1 showed weak antibacterial activity against Escherichia coli.

ศิริพร จึงสุทธิวงษ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-02-06
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  • Planta Medica
105 Structure-properties relationships in triarylamine-based push-pull systems-C60 dyads as active material for single-material organic solar cells Structure-properties relationships in triarylamine-based push-pull systems-C60 dyads as active material for single-material organic solar cells

The synthesis of a dyad involving a small arylamine-dicyanovinyl push-pull system as donor block and C60 fullerene as acceptor, connected by a flexible insulating linker formed by esterification of a β-hydroxymethylthiophene spacer is described. Unlike previously reported parent dyads with linkers connected at the 2-position of the thienyl spacer, this mode of connection allows the preservation of a free carbaldehyde group and thus the possibility to modulate the energy levels of the push-pull donor block. The electronic properties of the new dyad are analyzed by UV–Vis absorption spectroscopy, cyclic voltammetry, and theoretical calculations. A preliminary evaluation of this compound as active material for single-material organic solar cells is reported and discussed with reference to the mode of linkage of donor and C60 blocks.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-01-01
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  • Dyes and Pigments
106 Turn-on fluorescent probe towards glyphosate and Cr3+based on Cd(ii)-metal organic framework with Lewis basic sites Turn-on fluorescent probe towards glyphosate and Cr3+based on Cd(ii)-metal organic framework with Lewis basic sites

A microcrystalline Cd(II)-MOF, [Cd(NH2-bdc)(azp)]·DMF (NH2-H2bdc = 2-amino-1,4-benzenedicarboxylic acid and azp = 4,4′-azopyridine), namely 1-NH2 was rationally designed and synthesized as a fluorescent sensor in the off state utilizing the photo-induced electron transfer (PET) process. The crystal structure of 1-NH2 features a porous 2-fold interpenetrated 3D framework with 1D channels decorated with open Lewis basic amino and azo groups for recognizing the target species. Time-dependent density functional theory (TD-DFT) calculations were performed to gain insight into the PET process that induces the fluorescent quenching of 1-NH2. The proposed 1-NH2 is the first MOF that presents highly selective and sensitive visual turn-on fluorescence detection of glyphosate and Cr3+ with very low detection limits of 25 nM and 0.6 μM, respectively. The amino moiety in 1-NH2 plays a key role for the selective binding of Cr3+ to facilitate the sensitivity and selectivity of the detection. The fluorescent enhancement mechanism is associated with the inhibition of the PET process stimulated by the dissociation of the framework of 1-NH2 in the presence of glyphosate and Cr3+.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-01-01
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  • Inorganic Chemistry Frontiers
107 Co-embedded sulfur vacant MoS2 monolayer as a promising catalyst for formaldehyde oxidation: a theoretical evaluation† Co-embedded sulfur vacant MoS2 monolayer as a promising catalyst for formaldehyde oxidation: a theoretical evaluation†

In this work, we theoretically evaluated the complete catalytic oxidation of formaldehyde (HCHO) catalyzed by a cobalt embedded sulfur vacant MoS2 (COSv–MoS2) monolayer. The density functional theory calculations demonstrate that the Co atom is strongly anchored at the S vacancy site of the MoS2 monolayer forming a single-atom catalyst without metal clustering. From the study of all possible elementary steps, we propose two possible catalytic pathways for HCHO oxidation; (1) consecutive path: HCHO dehydrogenation followed by CO oxidation with O2, and (2) co-adsorption path: HCHO oxidation by O2 through the Langmuir–Hinshelwood mechanism. Compared to the catalysts reported in the literature, this catalyst presents lower activation energy barriers for C–H bond cleavage. At room temperature, the consecutive path is found to be dominant, and the calculated activation free energy barrier is only 0.46 eV (44.38 kJ mol−1). Our kinetic analyses show that HCHO oxidation can easily occur at room temperature with a rate of 1.12 × 105 s−1. Therefore, this non-noble metal single atom COSv–MoS2 catalyst demonstrates excellent activity for HCHO catalytic oxidation at low temperatures.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-10-07
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  • New Journal of Chemistry
108 Antitubercular and antibacterial activities of isoxazolines derived from natural products: Isoxazolines as inhibitors of Mycobacterium tuberculosis InhA Antitubercular and antibacterial activities of isoxazolines derived from natural products: Isoxazolines as inhibitors of Mycobacterium tuberculosis InhA

Isoxazoline derivatives of the natural products eugenol, 1’-S-acetoxychavicol acetate and sclareol are prepared through 1,3-dipolar cycloaddition reactions in an aqueous buffered system. The compounds are evaluated for their antitubercular and antibacterial activities. Compounds 2, 2a and 3f display strong antitubercular activity with minimum inhibitory concentration values of 26.68, 17.89 and 14.58µM, respectively. Furthermore, derivative 3f exhibits antibacterial activity against Bacillus cereus (minimum inhibitory concentration value of 29.16µM). Isoxazoline derivatives of 1’-Sacetoxychavicol acetate demonstrate improvements in cytotoxicity, and derivative 3f of sclareol demonstrates improved antitubercular and antibacterial activities. Isoxazolines derived from natural products exhibit Mycobacterium tuberculosis enoyl-acyl carrier protein reductase (InhA) inhibitory activity, and molecular modelling predicts that they form hydrogen bonding and hydrophobic interactions with NADH and with the key residues of the InhA binding site.

พรพรรณ พึ่งโพธิ์ Q4 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-11-01
    ชื่อวารสาร
  • Journal of Chemical Research
109 Ready-to-use paraquat sensor using a graphene-screen printed electrode modified with a molecularly imprinted polymer coating on a platinum core Ready-to-use paraquat sensor using a graphene-screen printed electrode modified with a molecularly imprinted polymer coating on a platinum core

We propose the fabrication of a novel ready-to-use electrochemical sensor based on a screen-printed graphene paste electrode (SPGrE) modified with platinum nanoparticles and coated with a molecularly imprinted polymer (PtNPs@MIP) for sensitive and cost-effective detection of paraquat (PQ) herbicide. Successive coating of the PtNPs surface with SiO2 and vinyl end-groups formed the PtNPs@MIP. Next, we terminated the vinyl groups with a molecularly imprinted polymer (MIP) shell. MIP was attached to the PtNPs cores using PQ as the template, methacrylic acid (MAA) as the monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, and 2,2′-azobisisobutyronitrile (AIBN) as the initiator. Coating the SPGrE surface with PtNPs@MIP furnished the PQ sensor. We studied the electrochemical mechanism of PQ on the MIP sensor using cyclic voltammetry (CV) experiments. The PQ oxidation current signal appears at -1.08 V and -0.71 V vs. Ag/AgCl using 0.1 M potassium sulfate solution. Quantitative analysis was performed by anodic stripping voltammetry (ASV) using a deposition potential of -1.4 V for 60 s and linear sweep voltammetric stripping. The MIP sensor provides linearity from 0.05 to 1000 μM (r2 = 0.999), with a lower detection limit of 0.02 μM (at -0.71 V). The compact imprinted sensor gave a highly sensitive and selective signal toward PQ. The ready-to-use MIP sensor can provide an alternative approach to the determination of paraquat residue on vegetables and fruits for food safety applications.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2021-10-21
    ชื่อวารสาร
  • The Analyst
110 0 0

A novel fluorometric assay for selective and sensitive determination of formalin (FA) was developed based on nitrogen-doped carbon dots (N-CDs) coupled with silver mirror reaction. N-CDs was synthesized using the hydrothermal method with the ethylene glycol and ammonia solution as carbon and nitrogen precursors, respectively. The detection principle was based on “off-on” fluorescence switching. Specifically, the fluorescence signal of N-CDs was first turned off after incorporating the Ag+ and Tollens’ reagents. Then, in the presence of FA, the Ag+ species on the N-CDs surface were reduced to Ag0 species and the fluorescence signal of N-CDs was switched back on. The fluorescence intensity due to the N-CDs signal linearly increased with the increasing FA concentrations in the range of 5–100 mg L−1, with the detection limit of 1.5 mg L−1. The proposed approach provides rapid, simple, sensitive, and selective detection of FA in various food samples.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-01-01
    ชื่อวารสาร
  • Talanta
111 Combined in situ XAS and DFT studies on the role of Pt in zeolite-supported metal catalysts for selective n-hexane isomerization Combined in situ XAS and DFT studies on the role of Pt in zeolite-supported metal catalysts for selective n-hexane isomerization

In this study, we used several in situ, and spectroscopy analyses to investigate the roles of platinum (Pt) in zeolite-supported Pt catalysts for selective n-alkane isomerization. HY zeolites were synthesized using the rice husk silica and impregnated with Pt precursor by incipient wetness impregnation. Typically, HY zeolites have proved to be active hydrocarbon cracking catalysts. The particular challenge is to find an effective catalyst, which favors the isomerization of n-alkanes without too much cracking. In this work, adding Pt atoms to HY zeolite provides an enhanced multifunctional catalyst for converting n-alkanes to branched hydrocarbons. To understand the effect of Pt, we further investigated the reaction mechanism of n-hexane isomerization to 2–methylpentane (2MP) and 3-methylpentane (3MP) by DFT simulations, using a cluster of 30T HY zeolite modeled through B3LYP + 3D calculations. We found that, at 450 °C, the isomerization on Pt-HY gives higher cracking products. Decreasing temperature to 300 °C yielded greater selectivity of branched hydrocarbons. In addition, DFT calculations demonstrate that the 2MP production via route A1 (C3-C4 bond activation) and a rate-determining step of 0.97 eV proved more thermodynamically and kinetically favorable than the 3MP product. This agrees well with our experimental observations. Consequently, the presence of Pt on the HY zeolite plays an essential role in both C–C forming and breaking. Finally, the Pt–HY zeolite is an efficient catalyst for petroleum production, improving the octane number for catalytic performance and product selectivity by isomerizing straight-chain alkanes to their branched chain isomers.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-04-15
    ชื่อวารสาร
  • Fuel
    DOI
112 Ag3PO4/Ag nanocomposite for selective and sensitive cyanide determination in food samples through catalytical colorimetry using a paper-based test kit Ag3PO4/Ag nanocomposite for selective and sensitive cyanide determination in food samples through catalytical colorimetry using a paper-based test kit

A paper-based test kit for selective and sensitive determination of cyanide was successfully developed using a Ag3PO4/Ag nanocomposite for catalytic colorimetry. The Ag3PO4/Ag nanocomposite synthesized via a one-step chemical bath method could instantly oxidize the chromogenic substrate ABTS for the color development under acidic conditions without the requirement of H2O2. During the detection step, cyanide in the sample was converted into gaseous hydrogen cyanide (HCN) using sulfuric acid. The HCN species then reacted with the generated Ag+ species via coordinate covalent bonding to form silver cyanide complex ions [Ag (CN2)]-. The amount of Ag+ species used for oxidizing ABTS subsequently decreased and so did the color intensity on the paper-based test kit. Specifically, the color intensity decreased with increasing cyanide concentrations in the range of 2.50–20.0 mg L−1. The limit of detection (LOD) and limit of quantification (LOQ) were 0.48 mg L−1 and 1.59 mg L−1, respectively. The developed test kit showed relatively high selectivity towards cyanide and high tolerance towards other cations and anions present in real samples. When applied to real samples including fruit juices and food products, the performance of the rapid and low-cost test kit was well validated by a conventional precipitation titration method. © 2022 Elsevier B.V.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-04-01
    ชื่อวารสาร
  • Sensors and Actuators B: Chemical
113 Smart sensor for assessment of oxidative/nitrative stress biomarkers using a dual-imprinted electrochemical paper-based analytical device Smart sensor for assessment of oxidative/nitrative stress biomarkers using a dual-imprinted electrochemical paper-based analytical device

We present a novel dual-imprinted electrochemical paper-based analytical device (Di-ePAD) to simultaneously determine 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 3-nitrotyrosine (3-NT) and assess oxidative and nitrative biomarkers in urine and plasma samples. The Di-ePAD was designed with hydrophobic barrier layers formed on filter paper to provide three-dimensional circular reservoirs and assembled electrodes. The molecularly imprinted polymer (MIP) was synthesized using a silica nanosphere decorated with silver nanoparticles (SiO2@AgNPs) as a core covered with dual-analyte imprinted sites on the polymer to recognize selectively and bind the target biomarkers. This strategy drives monodispersity and enhances the conductivity of the resulting MIP core-shell products. 3-NT-MIP and 8-OHdG-MIP were synthesized by successively coating the surface of SiO2@AgNPs with L-Cysteine via the thiol group, then terminating with MIP shells. The dual imprinted core-shell composites possess attractive properties for the target biomarkers' sensing, including catalytic activity, selectivity, and good conductivity. The Di-ePAD revealed excellent linear dynamic ranges of 0.01–500 μM for 3-NT and 0.05–500 μM for 8-OHdG, with detection limits of 0.0027 μM for 3-NT and 0.0138 μM for 8-OHdG. This newly developed method based on the synergistic effects of SiO2@AgNPs combined with promising properties of MIP offers outstanding selectivity, sensitivity, reproducibility, simplicity, and low cost for quantitative analysis of 3-NT and 8-OHdG. The proposed Di-ePAD showed good accuracy and precision when applied to actual samples, including urine and serum samples validated by a conventional HPLC method. 

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-01-25
    ชื่อวารสาร
  • Analytica Chimica Acta
114 Preparation of environment-friendly hydrophilic rubber from natural rubber grafted with sodium acrylate by reactive melt mixing Preparation of environment-friendly hydrophilic rubber from natural rubber grafted with sodium acrylate by reactive melt mixing

In this research, we present an easy way to prepare environment-friendly hydrophilic rubbers derived from natural rubber (NR) grafted with sodium acrylate (NaAA) through reactive blending using an internal mixer operated at a rotor speed of 80 rpm and 150°C. The key parameters affecting the grafting efficiency of NR-g-NaAA were investigated in terms of the fill factor (FF) of the chamber, mixing time, and NaAA content. Lastly, the grafted sample (with a suitable grafting efficiency) was crosslinked using peroxide curing to produce X(NR-g-NaAA) as a hydrophilic NR sample. Results showed that grafting efficiency of the NR-g-NaAA samples tended to decrease with increasing FF and NaAA contents owing to the higher chain-scission reaction rather than the free-radical generation on the NR molecules in the mastication step, while the optimal mixing time was only 4 min. The remarkable improvement in the hydrophilicity of NR by grafting with NaAA was established via the presence of C = O vibration of the ionized carboxylate group (–COO−) of NaAA located at 1559 cm−1. Increasing the grafting efficiency up to 69% resulted in a marked decrease in the water contact angle from 103° to 72° and enhanced the water swelling of the X(NR-g-NaAA) sample. © 2022 Society of Plastics Engineers.

ชัยวุฒิ วัดจัง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-06-01
    ชื่อวารสาร
  • Polymer Engineering and Science
115 0 0

Cadmium ion (Cd (II)) is a highly toxic heavy metal usually found in natural water. Exposure to Cd (II) can produce serious effects in human organs such as Itai-Itai disease. Therefore, the maximum allowance levels of Cd (II) in drinking water and herbal medicines imposed by the World Health Organization (WHO) are 3 μg L−1 and 300 μg kg−1, respectively. In this work, nitrogen-doped graphene quantum dots (N-GQDs) as a fluorescent sensor for Cd (II) determination was developed in both solution-based and paper-based systems. N-GQDs were synthesized from citric acid (CA) and ethylenediamine (EDA) via the hydrothermal method. The synthesized N-GQDs emitted intense blue fluorescence with a quantum yield (QY) of up to 80%. The functional groups on the surface of N-GQDs measured by FTIR were carboxyl (COO−), hydroxyl (OH−), and amine (NH2) groups, suggesting that they could be bound to Cd (II) for complexation. The fluorescence intensity of N-GQDs was gradually enhanced with the increase of Cd (II) concentration. This phenomenon was proved to result from the fluorescence enhancement (turn-on) based on the chelation enhanced fluorescence (CHEF) mechanism. Under the optimum conditions in the solution-based and paper-based systems, the limits of detection (LODs) were found to be 1.09 and 0.59 μg L−1, respectively. Furthermore, the developed sensors showed relatively high selectivity toward Cd (II) over ten other metal cations and six other anions of different charges. The performance of the sensor in real water and herbal medicine samples exhibited no significant difference as compared to the results of the validation method (ICP-OES). Therefore, the developed sensors can be used as fluorescent sensors for Cd (II) determination with high sensitivity, high selectivity, short incubation time (5 min). As such, the paper-based strategy has excellent promising potential for practical analysis of Cd (II) in water and herbal medicine samples with a trace level of Cd (II) concentrations.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-05-15
    ชื่อวารสาร
  • Talanta
116 Smartphone-Assisted Colorimetric Determination of Iron Ions in Water by Using Anthocyanin from Ruellia tuberosa L. as a Green Indicator and Application for Hands-on Experiment Kit Smartphone-Assisted Colorimetric Determination of Iron Ions in Water by Using Anthocyanin from Ruellia tuberosa L. as a Green Indicator and Application for Hands-on Experiment Kit

The present work describes a simple hands-on experiment kit for colorimetric quantification of ferric (III) ion (Fe3+) in an aqueous medium using anthocyanin extracted from Ruellia tuberosa L. as a green indicator. The extraction of a high amount of anthocyanin was easily accomplished by using only hot water instead of an organic solvent. The formation of the colored Fe3+-anthocyanin complex occurred on a homemade 24-well plate and the generated color was captured by a smartphone. The increase in color intensity was measured in the red, green, blue (RGB) system by the ImageJ software under the optimum conditions. The developed method enabled quantification of Fe3+ at low concentrations with the detection limit of 0.03 mg L-1 and provided the linear range (0.05-2.0 mg L-1) with good linearity (R2 = 0.9985) with Fe3+ concentration. The concentrations of Fe3+ in water samples determined by the developed method were not significantly different from those measured with UV-visible spectrophotometry at a 95% confidence level. In addition, the extracted anthocyanin stored at 4 °C was stable for two months. This hands-on experiment was implemented as a 2 h activity for 30 grade-12 students in which they were asked to determine the concentration of Fe3+ in a water sample using the smartphone-assisted colorimetric method. The students' understanding of the related concepts of oxidation-reduction and determination of iron was collected by a diagnostic conceptual test. Having participated in the experiment, the students were found to have significantly improved understanding of both concepts. 

ปุริม จารุจำรัส Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-04-12
    ชื่อวารสาร
  • Journal of Chemical Education
117 Microwave Synthesis of Blue Emissive N-Doped Carbon Quantum Dots as a Fluorescent Probe for Free Chlorine Detection Microwave Synthesis of Blue Emissive N-Doped Carbon Quantum Dots as a Fluorescent Probe for Free Chlorine Detection

Blue emissive N-doped carbon quantum dots (N-CQDs) were prepared through a convenient and sustainable microwave synthesis method using citric acid monohydrate (CA) and urea as carbon and nitrogen sources, respectively, with an optimum molar ratio of 1:3 (CA:Urea). The surface functional groups, morphology, and hydrodynamic characteristics of N-CQDs were analysed with Fourier-transform infrared (FTIR) spectroscopy, high-resolution transmission electron microscopy (HRTEM) and dynamic light scattering (DLS). The as-synthesised N-CQDs with a quantum yield of 14.8%, exhibited excitation-independent fluorescence emission at 443 nm due to surface-state-induced fluorescence, with an optimum excitation wavelength at 360 nm. The N-CQDs were spherical, with an average particle size of 7.29 ± 3.91 nm based on HRTEM analysis. However, DLS analysis showed that the hydrodynamic size (293.0 ± 110.8 nm) was larger than the average particle size due to the presence of hydrophilic polymer chains and abundant surface groups on the N-CQDs. The free chorine-induced fluorescence quenching of N-CQDs at pH 9 denotes the sensitivity of N-CQDs towards detection of free chlorine in the form of hypochlorite (ClO-) ion, providing the limit of detection (LOD) of 0.4 mM and limit of quantification (LOQ) of 1.2 mM. The fluorescence quenching effect in the N-CQDs caused by the quencher (ClO-) is attributed to the dynamic quenching mechanism, via an intersystem crossing. The low selectivity of N-CQDs towards various ions justified N-CQDs' selectivity as a free chlorine fluorescent probe that can be used for wastewater testing due to its high range sensitivity.

ปุริม จารุจำรัส Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-04-01
    ชื่อวารสาร
  • Sains Malaysiana
118 Preparation and characterization of wood-to-wood bonding adhesive by glycidyl methacrylate grafting natural rubber Preparation and characterization of wood-to-wood bonding adhesive by glycidyl methacrylate grafting natural rubber

In this study, a wood adhesive obtained from natural rubber (NR) was prepared by grafting glycidyl methacrylate (GMA)/styrene (St) at a weight ratio of 9/1 (NR-g-GMA) with the aid of a cumene hydroperoxide (CHP)/tetraethylene pentamine (TEPA) initiating system. The effect of reaction time on lap shear strength and the adhesion mechanism were investigated. A water contact angle on NR-g-GMA decreased from 95° to 54°; attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy confirmed the introduction of oxirane rings and St onto the NR; subsequently a ring-opening reaction in basic media occurred. In addition, dynamic mechanical analysis (DMA) showed that the storage modulus (G‘) of NR-g-GMA increased, whereas the glass transition temperature (Tg) slightly shifted to lower temperature and the height of tan δ decreased as compared to NR. The lap shear strength of NR-g-GMAs increased with increasing reaction time together with the hydroxyl content due to the ring-opening reaction, whereas the percentage grafting efficiency and the carbonyl content decreased after 4 h of reaction time. X-ray photoelectron spectroscopy (XPS) and ATR-FTIR showed that C–H, C[dbnd]O, and OH groups were mainly chemical compositions of wood and NR-g-GMA adhesive. Therefore, we propose that adsorption and molecular interaction were the main mechanisms determining adhesive strength.

ศิริวัฒน์ ระดาบุตร Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-04-01
    ชื่อวารสาร
  • International Journal of Adhesion and Adhesives
119 Sensitive electrochemical sensor based on gold nanoparticles assembled ferrocene-functionalised graphene oxide modified glassy carbon electrode for simultaneous determination of dopamine and acetaminophen Sensitive electrochemical sensor based on gold nanoparticles assembled ferrocene-functionalised graphene oxide modified glassy carbon electrode for simultaneous determination of dopamine and acetaminophen

In this article, a novel electron transfer mediator based on the ferrocene-functionalised graphene oxide (Fc-GO) was successfully synthesised by the amide linkage between amino (–NH2) in m-ferrocenylaniline (FcAni) and carboxylic (–COOH) in GO sheet through coupling reagents. This novel electroactive Fc-GO can effectively prevent the ferrocene mediator leaking from the electrode surface. Then, gold nanoparticles assembled ferrocene-functionalised graphene oxide (AuNPs@Fc-GO) was prepared and further confirmed by transmission electron microscopy (TEM), field emission scanning electron microscopy (FE-SEM) with energy dispersive X-ray spectroscopy (EDS), Fourier transform-infrared spectroscopy (FTIR) and X-ray powder diffractometer (XRD). The AuNPs@Fc-GO was modified on the surface of glassy carbon electrode (GCE) to construct an electrochemical sensor for sensitively simultaneous determination of dopamine (DA) and acetaminophen (AC). The characteristics toward DA and AC were investigated by the cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods. Simultaneous determination of both analytes was accomplished under the optimum condition. The oxidation peak potential of DA and AC was 0.20 and 0.43 V, respectively. The linear current response was obtained in the concentration range of 2–200 μM with the detection limit (S/N = 3) of 0.32 μM for DA and 2–200 μM with the detection limit of 0.21 μM for AC, respectively. Finally, the AuNPs@Fc-GO modified GCE was applied for the determination of DA and AC in human urine samples with satisfactory results. Therefore, the AuNPs@Fc-GO was a novel promising candidate for fabricating an electrochemical sensor for the determination of DA and AC in real biological samples.

เสนอ ชัยรัมย์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-03-01
    ชื่อวารสาร
  • Advances in Natural Sciences: Nanoscience and Nanotechnology
120 Fast, sensitive and selective simultaneous determination of paraquat and glyphosate herbicides in water samples using a compact electrochemical sensor Fast, sensitive and selective simultaneous determination of paraquat and glyphosate herbicides in water samples using a compact electrochemical sensor

We report a new ready-to-use sensor for simultaneous determination of paraquat (PQ) and glyphosate (GLY) based on a graphite screen-printed electrode modified with a dual-molecularly imprinted polymer coated on a mesoporous silica-platinum core. Amino-mesoporous silica nanoparticles (MSN-NH2) were first synthesized by a simple co-condensation method using tetraethyl orthosilicate and 3-aminopropyltrimethoxysilane. PtNPs were then decorated on the surface of MSN-NH2 by chemical reduction. Finally, the dual-MIP was successfully coated on the MSN-PtNP core. This 3D-surface-imprinting strategy enhances the conductivity and monodispersity of the MSN-PtNPs@d-MIP. Quantitative analysis was performed by differential pulse voltammetry with an oxidation current appearing at -0.95 V for PQ and +0.97 V for GLY. The dual-MIP sensor shows good linear calibration curves in the range of 0.025-500 μM for both analytes with detection limits of 3.1 nM and 4.0 nM for PQ and GLY, respectively. The dual-MIP sensor shows high selectivity and specificity, attributed to the increased affinity of the imprinted cavities formed on the polymer film for the target PQ and GLY molecules. The proposed dual-MIP sensor was successfully applied to detect PQ and GLY concentrations simultaneously in water samples. The ready-to-use dual-MIP sensor is well suited for water-quality control and on-site applications without sophisticated instrumentation. This journal is © The Royal Society of Chemistry.

มะลิวรรณ อมตธงไชย Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-02-28
    ชื่อวารสาร
  • Analytical Methods
    DOI
121 Nitrogen-doped carbon dots/Ni-MnFe-layered double hydroxides (N-CDs/Ni-MnFe-LDHs) hybrid nanomaterials as immunoassay label for low-density lipoprotein detection Nitrogen-doped carbon dots/Ni-MnFe-layered double hydroxides (N-CDs/Ni-MnFe-LDHs) hybrid nanomaterials as immunoassay label for low-density lipoprotein detection

Nitrogen-doped carbon dots/Ni-MnFe-layered double hydroxides (N-CDs/Ni-MnFe-LDHs) are demonstrated as superior peroxidase mimic antibody labels alternative to horseradish peroxidase (HRP) in an immunoassay, potentially overcoming some of the inherent disadvantages of HRP and other enzyme mimicking nanomaterials. They revealed efficient peroxidase-like activity and catalyzed the oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to form the intense blue product (at 620 nm) in the presence of hydrogen peroxide (H2O2). Using low-density lipoprotein (LDL) as a model target, an ultra-low limit of detection (0.0051 mg/dL) and a linear range of 0.0625–0.750 mg/dL were achieved, exhibiting higher sensitivity than the HRP-based immunoassay. Thus, the proposed N-CDs/Ni-MnFe-LDHs can be used as HRP mimicking analogs for developing highly sensitive colorimetric immunosensors for detection of biomarkers, as well as trace chemical analysis.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-02-01
    ชื่อวารสาร
  • Mikrochimica Acta
122 A new disposable electrochemical sensor for the individual and simultaneous determination of carbamate pesticides using a nanocomposite modified screen-printed electrode A new disposable electrochemical sensor for the individual and simultaneous determination of carbamate pesticides using a nanocomposite modified screen-printed electrode

In this work, we developed a disposable electrochemical sensor with improved sensitivity for the individual and simultaneous detection of carbaryl (CBR), fenobucarb (FNB), and carbosulfan (CBS) pesticides. The device used a screen-printed carbon electrode (SPCE) modified with a nanocomposite comprising manganese dioxide nanoparticles (MnO2) and graphene nanoplatelets (GNPs). We prepared the MnO2-GNPs nanocomposite by an in-situ growth method. The product was characterized by X-ray photoelectron spectrometry (XPS), X-ray diffraction (XRD), Fourier-transformed infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The disposable sensor was fabricated by inhouse-printing using only carbon ink on inexpensive transparency paper. We investigated the electrochemical performance of the developed sensor by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). The MnO2 and GNPs nanocomposite shows the highest electrocatalytic activity toward the oxidation of carbamate when in its phenol form. Under the optimized experimental conditions, the proposed strategy possess a good linear response of the disposable sensor for the individual determination of CBR, FNB and CBS in the concentration range of 1-40 μM, 5-150 μM and 50-600 μM with the low detection limit of 0.30 μM, 1.30 μM, 14.90 μM, respectively. Besides, the analytical performance of the proposed sensor for the simultaneous detection of CBR, FNB, and CBS exhibits a linear response in ranges of 1–30 µM, 5–80 µM, and 50–400 µM, with the limit of detection being 0.30, 1.40, and 15.15 µM, respectively. In addition, the sensor displays high reproducibility, repeatability, and good selectivity. The electrode simultaneously applied to determine the three carbamate residues in Jasmine rice and rice-field water samples. This developed electrochemical sensor is a promising high-sensitivity tool for fast, easy-to-use, low-cost electrochemical detection of multi-pesticide residues in agricultural samples.

อัญชลี สำเภา Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-02-01
    ชื่อวารสาร
  • Microchemical Journal
123 Theoretical study of metal-free catalytic for catalyzing CO-oxidation with a synergistic effect on P and N co-doped graphene Theoretical study of metal-free catalytic for catalyzing CO-oxidation with a synergistic effect on P and N co-doped graphene

P and N co-doped graphene (PNxCy-G with x = 1, 2, 3 and y = 0, 1, 2) is designed to enhance graphene reactivity with a synergistic effect of the P and N atoms for the CO oxidation reaction, focusing on the influence of the N dopant concentration on graphene. The calculated results indicate that increasing two or three coordinated N to P can facilitate charge transfer from the surface onto O2 molecules. However, the adsorbed O2 molecule breaks apart on PN3-G surface, affecting CO oxidation performance. Furthermore, PN2C1-G exhibits excellent catalytic activity towards the oxidation of CO via the ER mechanism, which catalyzes CO oxidation with the rate-determining step of only 0.26 eV for the first and 0.25 eV for the second oxidation at 0 K. Additionally, the catalytic oxidation of PN2C1-G via Eley–Rideal mechanism prefers to occur at room temperature (298.15 K), with a rate-determining step of 0.77 eV. The reaction rates at 298.15 K is calculated to be 5.36 × 1016 mol s–1. The rate constants are obtained according to harmonic transition state theory, which could be supportive for catalytic oxidation of CO on the experiment.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-12-01
    ชื่อวารสาร
  • Scientific Reports
124 Further Proof of Unconventional Conjugation via Disiloxane Bonds: Double Decker Sesquioxane [vinylMeSi(O0.5)2(PhSiO1.5)8(O0.5)2SiMevinyl] Derived Alternating Terpolymers Give Excited-State Conjugation Averaging That of the Corresponding Copolymers Further Proof of Unconventional Conjugation via Disiloxane Bonds: Double Decker Sesquioxane [vinylMeSi(O0.5)2(PhSiO1.5)8(O0.5)2SiMevinyl] Derived Alternating Terpolymers Give Excited-State Conjugation Averaging That of the Corresponding Copolymers

Here, we report the synthesis of DD SQ terpolymers with alternating biphenyl/terphenyl/stilbene and thiophene/hexylthiophene/bithiophene/thienothiophene linkers. These terpolymers were characterized using 1H and 13C nuclear magnetic resonance, gel permeation chromatography, matrix-assisted laser desorption/time-of-flight spectrometry, thermogravimetric analysis, and Fourier-transform infrared with the goal of combining long-wavelength emissions with high quantum yields. Density functional theory modeling studies using the Vienna ab initio simulation package and Gaussian 16 methods were also explored in attempts to determine HOMO-LUMO electronic configurations. Terpolymers' UV-vis properties demonstrate an emission intermediate between the respective copolymers rather than emission from both units as would be expected from physical mixtures, supporting electronic communication along polymer chains and through cages linked via disiloxane units as seen in previous reports on copolymers of the same systems. In addition, terpolymers of DD, thiophene, and terphenyl/stilbene offer φF that improved from 0.09 for DD/thiophene to 0.20 and 0.24, respectively. Compared to the corresponding terphenyl and stilbene copolymers, terpolymers display 35 nm red-shifted emissions, suggesting that it is possible to combine features of both copolymers in a single terpolymer, suggesting new opportunities to tailor photophysical properties by modifying structures, especially in systems with disiloxane linkers.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-09-27
    ชื่อวารสาร
  • Macromolecules
125 Reduced graphene oxide on silver nanoparticle layers-decorated titanium dioxide nanotube arrays as SERS-based sensor for glyphosate direct detection in environmental water and soil Reduced graphene oxide on silver nanoparticle layers-decorated titanium dioxide nanotube arrays as SERS-based sensor for glyphosate direct detection in environmental water and soil

When glyphosate, a widely used organophosphate herbicide in agricultural applications, contaminates the environment, it could lead to chronic harm to human health. Herein, an efficient, air-stable and reusable surface-enhanced Raman scattering (SERS) substrate was designed to be an analytical tool for direct determination of glyphosate. A vertical heterostructure of reduced graphene oxide (rGO)-wrapped dual-layers silver nanoparticles (AgNPs) on titania nanotube (TiO2 NTs) arrays was constructed as a SERS substrate. The TiO2 NTs/AgNPs-rGO exhibited high SERS performance for methylene blue detection, offering an analytical enhancement factor (AEF) as large as 7.1 × 108 and the limit of detection (LOD) as low as 10−14 M with repeatability of 4.4 % relative standard deviation (RSD) and reproducibility of 2.0 % RSD. The sensor was stable in ambient and was reusable after photo-degradation. The designed sensor was successfully applied for glyphosate detection with a LOD of 3 µg/L, which is below the maximum contaminant level of glyphosate in environmental water, as recommended by the U.S. EPA and the European Union. A uniqueness of this study is that there is no significant difference between the real-world applications of the SERS sensor on direct glyphosate analysis in environmental samples compared to an analysis using ultra-high performance liquid chromatography. 

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-09-05
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  • Journal of Hazardous Materials
126 In silico design of novel quinazoline-based compounds as potential Mycobacterium tuberculosis PknB inhibitors through 2D and 3D-QSAR, molecular dynamics simulations combined with pharmacokinetic predictions In silico design of novel quinazoline-based compounds as potential Mycobacterium tuberculosis PknB inhibitors through 2D and 3D-QSAR, molecular dynamics simulations combined with pharmacokinetic predictions

Serine/threonine protein kinase B (PknB) is essential to Mycobacterium tuberculosis (M. tuberculosis) cell division and metabolism and a potential anti-tuberculosis drug target. Here we apply Hologram Quantitative Structure Activity Relationship (HQSAR) and three-dimensional QSAR (Comparative Molecular Similarity Indices Analysis (CoMSIA)) methods to investigate structural requirements for PknB inhibition by a series of previously described quinazoline derivatives. PknB binding of quinazolines was evaluated by molecular dynamics (MD) simulations of the catalytic domain and binding energies calculated by Molecular Mechanics/Poisson Boltzmann Surface Area (MM-PBSA) and Molecular Mechanics/Generalized Born Surface Area (MM-GBSA) methods. Evaluation of a training set against experimental data showed both HQSAR and CoMSIA models to reliably predict quinazoline binding to PknB, and identified the quinazoline core and overall hydrophobicity as the major contributors to affinity. Calculated binding energies also agreed with experiment, and MD simulations identified hydrogen bonds to Glu93 and Val95, and hydrophobic interactions with Gly18, Phe19, Gly20, Val25, Thr99 and Met155, as crucial to PknB binding. Based on these results, additional quinazolines were designed and evaluated in silico, with HQSAR and CoMSIA models identifying sixteen compounds, with predicted PknB binding superior to the template, whose activity spectra and physicochemical, pharmacokinetic, and anti-M. tuberculosis properties were assessed. Compound, D060, bearing additional ortho- and meta-methyl groups on its R2 substituent, was superior to template regarding PknB inhibition and % caseum fraction unbound, and equivalent in other aspects, although predictions identified hepatotoxicity as a likely issue with the quinazoline series. These data provide a structural basis for rational design of quinazoline derivatives with more potent PknB inhibitory activity as candidate anti-tuberculosis agents. © 2022 Elsevier Inc.

สมจินตนา ทวีพานิชย์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-09-01
    ชื่อวารสาร
  • Journal of Molecular Graphics and Modelling
127 In silico design of novel quinazoline-based compounds as potential Mycobacterium tuberculosis PknB inhibitors through 2D and 3D-QSAR, molecular dynamics simulations combined with pharmacokinetic predictions In silico design of novel quinazoline-based compounds as potential Mycobacterium tuberculosis PknB inhibitors through 2D and 3D-QSAR, molecular dynamics simulations combined with pharmacokinetic predictions

Serine/threonine protein kinase B (PknB) is essential to Mycobacterium tuberculosis (M. tuberculosis) cell division and metabolism and a potential anti-tuberculosis drug target. Here we apply Hologram Quantitative Structure Activity Relationship (HQSAR) and three-dimensional QSAR (Comparative Molecular Similarity Indices Analysis (CoMSIA)) methods to investigate structural requirements for PknB inhibition by a series of previously described quinazoline derivatives. PknB binding of quinazolines was evaluated by molecular dynamics (MD) simulations of the catalytic domain and binding energies calculated by Molecular Mechanics/Poisson Boltzmann Surface Area (MM-PBSA) and Molecular Mechanics/Generalized Born Surface Area (MM-GBSA) methods. Evaluation of a training set against experimental data showed both HQSAR and CoMSIA models to reliably predict quinazoline binding to PknB, and identified the quinazoline core and overall hydrophobicity as the major contributors to affinity. Calculated binding energies also agreed with experiment, and MD simulations identified hydrogen bonds to Glu93 and Val95, and hydrophobic interactions with Gly18, Phe19, Gly20, Val25, Thr99 and Met155, as crucial to PknB binding. Based on these results, additional quinazolines were designed and evaluated in silico, with HQSAR and CoMSIA models identifying sixteen compounds, with predicted PknB binding superior to the template, whose activity spectra and physicochemical, pharmacokinetic, and anti-M. tuberculosis properties were assessed. Compound, D060, bearing additional ortho- and meta-methyl groups on its R2 substituent, was superior to template regarding PknB inhibition and % caseum fraction unbound, and equivalent in other aspects, although predictions identified hepatotoxicity as a likely issue with the quinazoline series. These data provide a structural basis for rational design of quinazoline derivatives with more potent PknB inhibitory activity as candidate anti-tuberculosis agents.

พรพรรณ พึ่งโพธิ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-09-01
    ชื่อวารสาร
  • Journal of Molecular Graphics and Modelling
128 In silico multiscale drug design to discover key structural features of potential JAK2 inhibitors In silico multiscale drug design to discover key structural features of potential JAK2 inhibitors

Background: JAK2 inhibitors have been proposed as a new therapeutic option for thalassemia therapy. The objective of this study was to discover the key structural features for improving 2-aminopyrimidine derivatives as potential JAK2 inhibitors. Materials & methods: Quantitative structure-activity relationship (QSAR) approaches (hologram QSAR and comparative molecular similarity indices analysis), molecular dynamics simulations, binding energy calculations and pharmacokinetic predictions were employed. Results: Reliable QSAR models, binding mode and binding interactions of JAK2 inhibitors were obtained and these obtained results were used as the key information for rational design of highly potent JAK2 inhibitors. Conclusion: The concept of new potential JAK2 inhibitors integrated from the obtained results was proved, producing two newly designed compounds, D01 and D02, with potential for use as JAK2 inhibitors.

พรพรรณ พึ่งโพธิ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-09-01
    ชื่อวารสาร
  • Future medicinal chemistry
    DOI
129 Improvement strategies on colorimetric performance and practical applications of Paper-based analytical devices Improvement strategies on colorimetric performance and practical applications of Paper-based analytical devices

Colorimetric paper-based analytical devices (PADs) have been widely fabricated due to the ease of construction of colorimetric reactions on paper and the high compatibility with low-cost and easy-to-use imaging devices for on-site analysis and results recording. However, the further advance of colorimetric PADs is limited by the detection sensitivity and other intrinsic limitations of paper regarding the color quality. This review summarizes the strategies for improving the colorimetric performances (color intensity and uniformity) of PADs. In particular, the principles of controlling liquid-paper interaction for the color intensity enhancement, developed in printing research, are discussed in relation to PAD designs. The influence of the paper assaying environment to the paper assaying selectivity is discussed through a case study for the first time. Image capture techniques and image process algorithms are related to the accuracy and sensitivity of the colored results, which are carefully introduced. Finally, based on the tendency of improvement of colorimetric PADs for practical applications, we summarized the designs that enhance the portability of colorimetric PADs. It is believed that the new links and opinions provided in this review may be useful to researchers to address the challenges in designing future colorimetric PADs with improved sensitivities for field use.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-09-01
    ชื่อวารสาร
  • Microchemical Journal
130 Virtual Screening Identifies Novel and Potent Inhibitors of Mycobacterium tuberculosis PknB with Antibacterial Activity Virtual Screening Identifies Novel and Potent Inhibitors of Mycobacterium tuberculosis PknB with Antibacterial Activity

Mycobacterium tuberculosis protein kinase B (PknB) is essential to mycobacterial growth and has received considerable attention as an attractive target for novel anti-tuberculosis drug development. Here, virtual screening, validated by biological assays, was applied to select candidate inhibitors of M. tuberculosis PknB from the Specs compound library (www.specs.net). Fifteen compounds were identified as hits and selected for in vitro biological assays, of which three indoles (2, AE-848/42799159; 4, AH-262/34335013; 10, AP-124/40904362) inhibited growth of M. tuberculosis H37Rv with minimal inhibitory concentrations of 6.2, 12.5, and 6.2 μg/mL, respectively. Two compounds, 2 and 10, inhibited M. tuberculosis PknB activity in vitro, with IC50 values of 14.4 and 12.1 μM, respectively, suggesting this to be the likely basis of their anti-tubercular activity. In contrast, compound 4 displayed anti-tuberculosis activity against M. tuberculosis H37Rv but showed no inhibition of PknB activity (IC50 > 128 μM). We hypothesize that hydrolysis of its ethyl ester to a carboxylate moiety generates an active species that inhibits other M. tuberculosis enzymes. Molecular dynamics simulations of modeled complexes of compounds 2, 4, and 10 bound to M. tuberculosis PknB indicated that compound 4 has a lower affinity for M. tuberculosis PknB than compounds 2 and 10, as evidenced by higher calculated binding free energies, consistent with experiment. Compounds 2 and 10 therefore represent candidate inhibitors of M. tuberculosis PknB that provide attractive starting templates for optimization as anti-tubercular agents. 

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-08-22
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  • Journal of Chemical Information and Modeling
131 0 0

Fourteen undescribed phloroglucinol-meroterpenoids, namely eucalypcamals A–N, were isolated from a CH2Cl2 extract of the leaves of Eucalyptus camaldulensis Dehnh. In addition, from the same extract, twelve known phloroglucinols, three known flavonoids, and four known phenolic compounds were also isolated. The structures of the undescribed compounds were analyzed by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and high resolution electrospray ionization mass spectrometry (HRESIMS). The assignments of the absolute configurations were performed by comparing the experimental electronic circular dichroism (ECD) data with the calculated values. Eucalyprobusal E was found to be cytotoxic against HCT116, Jurkat, and MDA-MB-231 cell lines with IC50 values of 17.6, 9.44, and 17.9 μM, respectively. Eucalrobusone F exhibited antibacterial activity against methicillin-resistant S. aureus (MRSA) and S. aureus with minimum inhibitory concentration/minimum bactericidal concentration (MIC/MBC) values of 4/4 μg/mL while euglobal Ia1 showed antifungal activity with MIC/MFC values of 16/16 μg/mL. 

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-08-01
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  • Phytochemistry
132 Voltammetric lipase activity assay based on dilinolein and a modified carbon paste electrode Voltammetric lipase activity assay based on dilinolein and a modified carbon paste electrode

In this work, a novel electrochemical assay for characterizing both lipases and lipase inhibitors as well as for the determination of lipase activity is described. It is based on a carbon paste electrodemodified with cobalt(II)phthalocyanine, and multi-walled carbon nanotubes (MWCNTs). As reaction media, a sodium borate buffer was used (0.1 M, pH 9). The measurements were carried out in a batch system using differential pulse voltammetry (DPV) and 1,3-dilinolein as standard substrate. The activity assay showed a linearity for porcine pancreas lipase activity in a range between 20 and 300 U L−1 (per min) with a limit of detection (LOD) of 7 U L−1 and a limit of quantification (LOQ) of 20 U L−1. The kinetic behavior of the lipase reaction was investigated, resulting in a KM value of 0.29 mM. The applicability of the activity assay could be shown by investigating the activity of lipases from Aspergillus oryzae and Candida rugosa, and the results were confirmed by a reference method. The inhibitory effects were characterized with Orlistat. Graphical abstract: [Figure not available: see fulltext.] © 2022, The Author(s).

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-07-01
    ชื่อวารสาร
  • Analytical and Bioanalytical Chemistry
133 Styrene-assisted acrylic acid grafting onto polypropylene surfaces: preparation, characterization, and an automatically latex-coagulating application Styrene-assisted acrylic acid grafting onto polypropylene surfaces: preparation, characterization, and an automatically latex-coagulating application

This work aimed to modify the polypropylene (PP) surface by grafting with acrylic acid (AA) monomer in toluene solution using styrene (ST) and benzoyl peroxide (BPO) as comonomer and initiator, respectively, for potential application as an automatically latex-coagulating cup. The grafting percentage of PP-g-PAA was slightly increased with increasing time of surface activation, grafting reaction time, and concentrations BPO and AA. Interestingly, the presence of ST comonomer significantly improved the grafting percentage of AA onto PP sheets (PP-g-P(ST-co-AA)) and its ion exchange capacity from 5.76 to 25% and 8.87 × 10–5 to 43.1 × 10–5 meq/g, respectively. This indicated that the incorporation of ST could significantly enhance the grafting reaction of AA onto the PP surfaces. The possible mechanism of grafting reaction was also described and demonstrated. Besides, the PP-g-P(ST-co-AA)25 exhibited high coagulum performance of natural rubber latex (NRL) of 93.8% and high NRL coagulation rate of 63.5% %/h. Thus, the grafted PP with ST/AA monomers as an automatically latex-coagulating cup/container could offer not only the lower production cost and lesser environmental problems but also improved properties, qualities, and price of cup lump products. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

ชัยวุฒิ วัดจัง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-06-16
    ชื่อวารสาร
  • Polymer Bulletin
134 An electrochemical sensor for the voltammetric determination of artemisinin based on carbon materials and cobalt phthalocyanine An electrochemical sensor for the voltammetric determination of artemisinin based on carbon materials and cobalt phthalocyanine

An electrochemical sensor for the determination of artemisinin has been developed based on a glassy carbon electrode modified with hybrid nanocomposites of cobalt phthalocyanine, graphene nanoplatelets, multi-walled carbon nanotubes and ionic liquids (IL). To improve the sensitivity and selectivity of the sensorcobalt phthalocyanine (CoPc) was used as an effective redox mediator to promote and catalyze the artemisinin reduction. Furthermore, the graphene nanoplatelets and multi-walled carbon nanotubes were used as excellent conducting supporting materials to improve the sensitivity of the electrochemical sensor. Moreover, IL with a surface charge was also employed to prevent aggregation of the graphene nanoplatelets and multi-walled carbon nanotubes. The analytical signal was generated from the reduction of Co(III)Pc generated by artemisinin. The proposed electrochemical sensor was applied to the detection of artemisinin using differential pulse voltammetry and provided a signal with wide linearity ranging from 1.5–60 μM and 60–600 μM and a detection limit of 0.70 μM (3SD/m). Furthermore, the proposed sensor displayed good repeatability and reproducibility of 2.9–3.0 and 3.1–4.4% RSD, respectively. Applications of the sensor to drug and plant samples demonstrated accuracy in a range of 105–116% recoveries. In addition, the results were in good agreement with those obtained from the HPLC method as a reference technique. Thus, the proposed electrochemical sensor provides a new alternative platform for sensitive and selective determination of artemisinin in the analysis of pharmaceuticals with good precision and accuracy. Graphical abstract: [Figure not available: see fulltext.]. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-06-01
    ชื่อวารสาร
  • Microchimica Acta
135 A compact N-nitrosodiphenylamine imprinted sensor based on a Pd nanoparticles-MIP microsphere modified screen-printed graphene electrode A compact N-nitrosodiphenylamine imprinted sensor based on a Pd nanoparticles-MIP microsphere modified screen-printed graphene electrode

Herein, we report the fabrication of a compact voltammetric sensor for the sensitive and selective determination of N-nitrosodiphenylamine (NDPhA) based on a screen-printed graphene electrode modified with a molecularly imprinted polymer coating on a palladium nanoparticle core (PdNPs@MIP/SPGrE). In addition, a novel approach for 3D-imprinting of NDPhA on the PdNPs surface is presented. PdNPs were first synthesized by chemical reduction using sodium borohydride. Then, Core-shell polymerization was achieved by successively coating the surface of PdNPs with poly(vinylpyrrolidone) and terminating with an MIP consisting of poly(N-Isopropylacrylamide)-co-trimethylolpropane trimethacrylate. Morphological, structural, and electrochemical characterization reveals that the as-prepared micro-sized spherical PdNPs@MIP has a uniform, high electro-catalytic activity and a specific surface area with many NDPhA imprinted sites. We constructed the compact NDPhA imprinted sensor by coating the SPGrE surface with PdNPs@MIP. Quantitative analysis was performed by linear sweep anodic stripping voltammetry (LSASV) using a deposition potential of +0.02 V for 60 s. The linear working ranges for NDPhA measurements were 0.01–0.1 μM (r2 = 0.996) and 0.1–100 μM (r2 = 0.992) with corresponding sensitivities of 51.935 and 0.821 (μA s) µM−1, respectively. The system provides a good precision of %RSD 1.67% with an estimated detection limit (3Sbn = 3) of 0.0013 μM. The intraday and inter-day accuracy (%bias) of the certified reference material (CRM) are −0.74% and −1.01%, respectively. We demonstrate the successful application of the fabricated compact sensor to determine NDPhA in beverage and synthetic samples. The compact NDPhA imprinted sensor can provide an alternative approach to food quality control. © 2022 Elsevier B.V.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-06-01
    ชื่อวารสาร
  • Journal of Electroanalytical Chemistry
136 Composite proton conducting membranes from crosslinked poly(vinyl alcohol)/chitosan and silica particles containing poly(2-acrylamido-2-methyl-1-propansulfonic acid) Composite proton conducting membranes from crosslinked poly(vinyl alcohol)/chitosan and silica particles containing poly(2-acrylamido-2-methyl-1-propansulfonic acid)

Proton conducting membranes based on crosslinked poly(vinyl alcohol) and chitosan were fabricated using sulfosuccinic acid (SSA) and glutaraldehyde (GA) as crosslinking agents. A systematic study on the effects of SSA, chitosan, and GA on membrane properties was conducted. The most promising crosslinked membrane was then chosen to form composites with silica particles containing poly(2-acrylamido-2-methyl-1-propanesulfonic acid) (PAMPS-Si). Two different sizes of PAMPS-Si with similar PAMPS contents were synthesized from vinyltrimethoxysilane precursor following the Stöber method. The process was followed by free radical polymerization of 2-acrylamido-2-methyl-1-propansulfonic acid. Field-emission scanning electron microscopy, thermogravimetric analysis, and Fourier-transform infrared spectroscopy techniques were used to analyze the sample. The results revealed the successful synthesis of PAMPS-Si. All prepared composite membranes exhibited comparable water vapor absorption, water uptake, and ion exchange capacities. The addition of PAMPS-Si enhanced proton conductivity, and the value increased with increasing loading. The size of the PAMPS-Si particles did not significantly affect the proton conductivity. These composite membranes demonstrated good thermal and oxidative stabilities.

ประนอม แซ่จึง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-05-20
    ชื่อวารสาร
  • Journal of Applied Polymer Science
137 Accelerated Decomposition of Potassium Permanganate in Ferrocenium Ion as Ferrocenium-Doped Manganese(IV) Oxide for Selective Oxidation of Alcohols Accelerated Decomposition of Potassium Permanganate in Ferrocenium Ion as Ferrocenium-Doped Manganese(IV) Oxide for Selective Oxidation of Alcohols

Ferrocenium-doped manganese(IV) oxide (Fc+/MnO2) was synthesized through accelerated decomposition of KMnO4 in the presence of ferrocenium ion (Fc+) generated by concentrated sulfuric acid. The corresponding catalysts enabled highly efficient oxidation of alcohols with aldehyde or ketone.

เสนอ ชัยรัมย์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-05-05
    ชื่อวารสาร
  • SYNLETT
138 Discovery of novel and potent InhA inhibitors by an in silico screening and pharmacokinetic prediction Discovery of novel and potent InhA inhibitors by an in silico screening and pharmacokinetic prediction

Aim: In silico screening approaches were performed to discover novel InhA inhibitors. Methods: Candidate InhA inhibitors were obtained from the combination of virtual screening and pharmacokinetic prediction. In addition, molecular mechanics Poisson-Boltzmann surface area, molecular mechanics Generalized Born surface area and WaterSwap methods were performed to investigate the binding interactions and binding energy of candidate compounds. Results: Four candidate compounds with suitable physicochemical, pharmacokinetic and antibacterial properties are proposed. The crucial interactions of the candidate compounds were H-bond, pi-pi and sigma-pi interactions observed in the InhA binding site. The binding affinity of these compounds was improved by hydrophobic interactions with hydrophobic side chains in the InhA pocket. Conclusion: The four newly identified InhA inhibitors reported in this study could serve as promising hit compounds against Mycobacterium tuberculosis and may be considered for further experimental studies.

พรพรรณ พึ่งโพธิ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-05-01
    ชื่อวารสาร
  • Future Medicinal Chemistry
139 α-Glucosidase Inhibitors from the Stems of Knema globularia α-Glucosidase Inhibitors from the Stems of Knema globularia

Six new compounds, globunones A-F (1-6), and two new flavonoids (7 and 8) together with nine known compounds (9-17) were isolated from the stems of Knema globularia. The chemical structures of 1-8 were elucidated by an analysis of their NMR and high-resolution electrospray ionization mass spectrometry data as well as by comparison with literature values. The absolute configurations were determined using time-dependent density functional theory electronic circular dichroism (TD-DFT-ECD). Globunones A-E (1-5) represent the initial combined structures of a flavan-3-ol core and a 1,4-benzoquinone core. Globunone F (6) is the first flavanone-type compound bearing a 2-(2,4-dihydroxyphenyl)-2-oxoethyl group found to date in Nature. Compounds 1-3 and 6-17 were tested for their yeast α-glucosidase inhibitory activity. All compounds tested (except for 13 and 14) showed potent inhibition toward α-glucosidase with IC50values in the range 0.4-26.6 μM. Calodenin A (15) was the most active compound with an IC50value of 0.4 μM (the positive control, acarbose, IC5093.6 μM). A kinetic analysis of 15 revealed that it is a noncompetitive inhibitor with a Kivalue of 3.4 μM. © 2022 American Chemical Society. All rights reserved.

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-04-22
    ชื่อวารสาร
  • Journal of Natural Products
140 Cobalt(II)-Hexaazatriphenylene Hexacarbonitrile Coordination Compounds Based Cathode Materials with High Capacity and Long Cycle Stability Cobalt(II)-Hexaazatriphenylene Hexacarbonitrile Coordination Compounds Based Cathode Materials with High Capacity and Long Cycle Stability

Organic cathode materials are plagued by their low cycle stability and poor electronic conductivity, even though they have attracted increasing attention in the context of lithium-ion batteries (LIBs). Herein, a coordination polymer cobalt-hexaazatriphenylene hexacarbonitrile (Co(HAT-CN)) is prepared via a facile solvothermal method, which is composed of the redox-active HAT-CN linker and the Co(II) ion center. The fabricated material shows excellent structural stability and high conductivity. Moreover, graphene oxide (GO) is introduced as a substrate, and in-situ loading of Co(HAT-CN) on its surface shows enhanced cycling stability. For Co(HAT-CN)/GO, a high specific capacity of 204 mAh g–1 can be retained even after 200 cycles at a current density of 40 mA g–1 in a voltage window of 1.2–3.9 V. Ex situ and in situ analyses are applied to probe the reversibility of the pyrazine redox-active center during the cycling process and the lithium storage process. Density functional theory calculations reveal that the high conductivity of Co(HAT-CN) should be ascribed to the narrow LUMO-HOMO gap (0.61 eV), and strong binding of lithiated molecules. © 2022 Wiley-VCH GmbH.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-04-19
    ชื่อวารสาร
  • Advanced Functional Materials
141 Identification of Potent DNA Gyrase Inhibitors Active against Mycobacterium tuberculosis Identification of Potent DNA Gyrase Inhibitors Active against Mycobacterium tuberculosis

Mycobacterium tuberculosis DNA gyrase manipulates the DNA topology using controlled breakage and religation of DNA driven by ATP hydrolysis. DNA gyrase has been validated as the enzyme target of fluoroquinolones (FQs), second-line antibiotics used for the treatment of multidrug-resistant tuberculosis. Mutations around the DNA gyrase DNA-binding site result in the emergence of FQ resistance in M. tuberculosis; inhibition of DNA gyrase ATPase activity is one strategy to overcome this. Here, virtual screening, subsequently validated by biological assays, was applied to select candidate inhibitors of the M. tuberculosis DNA gyrase ATPase activity from the Specs compound library (www.specs.net). Thirty compounds were identified and selected as hits for in vitro biological assays, of which two compounds, G24 and G26, inhibited the growth of M. tuberculosis H37Rv with a minimal inhibitory concentration of 12.5 μg/mL. The two compounds inhibited DNA gyrase ATPase activity with IC50values of 2.69 and 2.46 μM, respectively, suggesting this to be the likely basis of their antitubercular activity. Models of complexes of compounds G24 and G26 bound to the M. tuberculosis DNA gyrase ATP-binding site, generated by molecular dynamics simulations followed by pharmacophore mapping analysis, showed hydrophobic interactions of inhibitor hydrophobic headgroups and electrostatic and hydrogen bond interactions of the polar tails, which are likely to be important for their inhibition. Decreasing compound lipophilicity by increasing the polarity of these tails then presents a likely route to improving the solubility and activity. Thus, compounds G24 and G26 provide attractive starting templates for the optimization of antitubercular agents that act by targeting DNA gyrase. 

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-04-11
    ชื่อวารสาร
  • Journal of Chemical Information and Modeling
142 Physicochemical investigation of the enhanced removal of methylene blue from aqueous solution using polydopamine/silver nanoparticles Physicochemical investigation of the enhanced removal of methylene blue from aqueous solution using polydopamine/silver nanoparticles

Polydopamine/Ag (PDA/Ag) nanoparticles were synthesized for methylene blue (MB) removal from aqueous solution as a model dye. These particles were prepared in a modified literature procedure in which polydopamine (PDA) nanoparticles were first prepared via the oxidative polymerization of dopamine (DA) under alkaline conditions in the presence of oxygen. Subsequently, nanoparticulate PDA/Ag was accessed from direct reduction of silver precursor [Ag(NH3)2]+ ions by catechol amino groups in the PDA structure to form Ag nanoparticles (AgNPs) fixed on the PDA surface. Confirmation of the formation of the PDA and PDA/Ag nanoparticles, plus characterization of their surface morphologies was achieved. In the MB adsorption studies, the various factors affecting the dye adsorption and thermodynamic parameters were investigated in detail. This adsorption process can be described well by the Langmuir model. In order to gain a deeper molecular insight into this process, we investigated some possible local model structures of PDA/Ag nanoparticles and MB interaction with these structures using density functional theory (DFT) calculations. The results indicated that the adsorption energies (E ads) of MB on the PDA/Ag nanoparticles were higher than the E ads of MB on PDA nanoparticles, which was consistent with the experimental results. Our results provide a significant new finding for the role of Ag nanoparticles in the MB adsorption process on PDA/Ag nanoparticles. Readily accessible nanoparticulate PDA/Ag was shown to be a highly effective adsorbent for MB from aqueous solution and thus has significant potential for applications in wastewater dye removal.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-03-24
    ชื่อวารสาร
  • Journal of the Textile Institute
143 Imidazole-doped proton conducting composite membranes fabricated from double-crosslinked poly(vinyl alcohol) and zeolitic imidazolate framework Imidazole-doped proton conducting composite membranes fabricated from double-crosslinked poly(vinyl alcohol) and zeolitic imidazolate framework

Proton conducting membranes were fabricated from double-crosslinked poly(vinyl alcohol) and zeolitic imidazolate framework (ZIF). The effect of the ZIF type (ZIF-8, ZIF-67, and a 1:1 wt/wt. mixture (ZIF-mix)) on water uptake, ion exchange capacity, proton conductivity, and oxidative stability of the composite membranes was studied. The membrane comprising ZIF-mix exhibited the highest proton conductivity, suggesting a synergistic effect between ZIF-8 and ZIF-67. The influence of ZIF-mix content on the membrane properties was further investigated, and the optimum loading was 7.5%. The introduction of ZIF-mix provided an improvement in proton conductivity and mechanical strength. Moreover, all composite membranes demonstrated low water uptake, low methanol uptake, adequate thermal stability, and high oxidative stability. To the best of our knowledge, this was the first time a ZIF-mix composite membrane was doped with imidazole to improve proton conductivity under non-humidified conditions. The proton conductivity of the imidazole-doped 7.5%ZIF-mix membrane increased with increasing imidazole content and temperature.

ประนอม แซ่จึง Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-03-23
    ชื่อวารสาร
  • Polymer
144 Inhibition of Mycobacterium tuberculosis InhA by 3-nitropropanoic acid Inhibition of Mycobacterium tuberculosis InhA by 3-nitropropanoic acid

3-Nitropropanoic acid (3NP), a bioactive fungal natural product, was previously demonstrated to inhibit growth of Mycobacterium tuberculosis. Here we demonstrate that 3NP inhibits the 2-trans-enoyl-acyl carrier protein reductase (InhA) from Mycobacterium tuberculosis with an IC50 value of 71 μM, and present the crystal structure of the ternary InhA-NAD+-3NP complex. The complex contains the InhA substrate-binding loop in an ordered, open conformation with Tyr158, a catalytically important residue whose orientation defines different InhA substrate/inhibitor complex conformations, in the “out” position. 3NP occupies a hydrophobic binding site adjacent to the NAD+ cofactor and close to that utilized by the diphenyl ether triclosan, but binds predominantly via electrostatic and water-mediated hydrogen-bonding interactions with the protein backbone and NAD+ cofactor. The identified mode of 3NP binding provides opportunities to improve inhibitory activity toward InhA. 

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-03-01
    ชื่อวารสาร
  • Proteins: Structure, Function and Bioinformatics
145 Hydrothermal synthesis of nitrogen-doped graphene quantum dots as a fluorescent probe to detect mercury (II) ions in an aqueous sample Hydrothermal synthesis of nitrogen-doped graphene quantum dots as a fluorescent probe to detect mercury (II) ions in an aqueous sample

The N-doped graphene quantum dots (N-GQDs) with a high quantum yield of 36.23% were synthesised through a facile hydrothermal method by using citric acid monohydrate (CA) and ethylenediamine (EDA) as the carbon and nitrogen precursors, respectively. The morphology and the surface functional group of N-GQDs were analysed by using Fourier transform infrared (FTIR) spectroscopy and high-resolution transmission electron microscopy (HRTEM) while the optical properties were observed with UV–Vis spectroscopy and photoluminescence spectroscopy (PL). The synthesised N-GQDs were reported to form in a spherical shape with an average particles size of 9.96 ± 4.4 nm based on the HRTEM analysis. Furthermore, the as-prepared N-GQDs emitted a bright blue fluorescence emission with an excitation-independent fluorescence emission at 440 nm with the excitation wavelength at 340 nm. Linear regression between fluorescence intensity and Hg2+ ions at different concentrations was obtained and the limit of detection (LOD) and the limit of quantification (LOQ) were calculated as 2.46 μM and 7.45 μM, respectively. In addition, the fluorescence quenching effect that occurs in the interaction between Hg2+ ions and N-GQDs corresponded to the dynamic quenching mechanism. The higher selectivity towards Hg2+ ions proved that this synthesised N-GQDs could be used as a fluorescent probe to detect Hg2+ ions in an aqueous solution.

ปุริม จารุจำรัส Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-02-01
    ชื่อวารสาร
  • Emergent Materials
146 Facile and Compact Electrochemical Paper-Based Analytical Device for Point-of-Care Diagnostic of Dual Carcinogen Oxidative Stress Biomarkers through a Molecularly Imprinted Polymer Coated on Graphene Quantum-Dot Capped Gold Facile and Compact Electrochemical Paper-Based Analytical Device for Point-of-Care Diagnostic of Dual Carcinogen Oxidative Stress Biomarkers through a Molecularly Imprinted Polymer Coated on Graphene Quantum-Dot Capped Gold

Nanoscale imprinting significantly increases the specific surface area and recognition capabilities of a molecularly imprinted polymer by improving accessibility to analytes, binding kinetics, and template removal. Herein, we present a novel synthetic route for a dual molecularly imprinted polymer (dual-MIP) of the carcinogen oxidative stress biomarkers 3-nitrotyrosine (3-NT) and 4-nitroquinolin-N-oxide (4-NQO) as coatings on graphene quantum-dot capped gold nanoparticles (GQDs-AuNPs). The dual-MIP was successfully coated on the GQDs-AuNPs core via a (3-mercaptopropyl) trimethoxysilane (MPTMS) linkage and copolymerization with the 3-aminopropyltriethoxysilane (APTMS) functional monomer. In addition, we fabricated a facile and compact three-dimensional electrochemical paper-based analytical device (3D-ePAD) for the simultaneous determination of the dual biomarkers using a GQDs-AuNPs@dual-MIP-modified graphene electrode (GQDs-AuNPs@dual-MIP/SPGE). The developed dual-MIP device provides greatly enhanced electrochemical signal amplification due to the improved electrode-specific surface area, electrocatalytic activity, and the inclusion of large numbers of dual-imprinted sites for 3-NT and 4-NQO detection. Quantitative analysis used square wave voltammetry, with an oxidation current appearing at -0.10 V for 4-NQO and +0.78 V for 3-NT. The dual-MIP sensor revealed excellent linear dynamic ranges of 0.01 to 500 μM for 3-NT and 0.005 to 250 μM for 4-NQO, with detection limits in nanomolar levels for both biomarkers. Furthermore, the dual-MIP sensor for the simultaneous determination of 3-NT and 4-NQO provides high accuracy and precision, with no evidence of interference from urine, serum, or whole blood samples. 

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-12-06
    ชื่อวารสาร
  • Analytical Chemistry
147 The Development of the Fluorescence-based Portable Device for Lead (II) and Formalin Determination in Food Samples by Using Nitrogen-Doped Carbon Dots (N-CDs) The Development of the Fluorescence-based Portable Device for Lead (II) and Formalin Determination in Food Samples by Using Nitrogen-Doped Carbon Dots (N-CDs)

The fluorescence-based portable device for the determination of lead (Pb2+) and formalin (FA) in food samples by using Nitrogen-doped carbon dots (N-CDs) as a fluorescence probe was developed. The proposed approach, Pb2+, and FA were determined based on the photo-induced electron transfer (PET) mechanism and the silver mirror reaction. The fluorescence intensity of the N-CDs decreased with the increase of Pb2+ concentration and increased with the increasing FA concentration. The fluorescence intensity of N-CDs after the reactions were measured by a filter-free fluorometer platform using a commercial camera module and a Raspberry Pi, a compact computer, as a detector and processor. The experimental results were obtained using control samples with known Pb2+ and FA concentrations in the 0.01-10 mg L− 1 and 25–150 mg L− 1, respectively. The proposed approach is simple, low-cost, and accurate for the on-site monitoring of Pb2+ and FA in various food samples. Of utmost importance, the proposed approach is expected to be a pioneering model for the future development of other analytes with a broad range of practical applications.

ปุริม จารุจำรัส Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-12-01
    ชื่อวารสาร
  • Journal of Fluorescence
148 Superhydrophobic and superoleophiclic natural rubber latex foam coated by hexadecyltrimethoxysilane modified halloysite nanotube for oil/water separation Superhydrophobic and superoleophiclic natural rubber latex foam coated by hexadecyltrimethoxysilane modified halloysite nanotube for oil/water separation

In this research, we introduce a facile synthesis of the superhydrophobic natural rubber latex foam (NRLF), sponge-NRLF materials with a high oil-sorption capacity. The superhydrophobic sponge-NRLF was prepared by decorating the halloysite nanotubes (HNTS), which are chemically modified by n-hexadecyltrimethoxysilane (HDTMS) on the surface. The effects of HDTMS@HNTs loading and vulcanization systems towards the superhydrophobic and superhydrophilic properties of the NRLF were investigated. It was found that NRLF vulcanized by conventional vulcanization system (CV) and coated with 6 wt% HDTMS@HNTs showed favorable oil/water selectivity with excellent water repellence with a contact angle of 151°. The modified NRLF showed excellent performance toward gasoline 95 with high sorption capacity, achieving up to 10 times of its own weight for a wide range of oils. Oil sorption capacity tended to decline with respect to increasing HDTMS@HNTs content and oil viscosity due to the reduced porosity and surface area of the modified NRLF. Interestingly, the modified NRLF exhibited excellent durability, as the sorption efficiency remained unchanged after 10 cycles. Moreover, their fire retardant was also improved. 

ศิริวัฒน์ ระดาบุตร Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-12-01
    ชื่อวารสาร
  • Materials Today Communications
149 0 0

Palladium catalyst supported on chitosan-EDTA composite, CS-EDTA-Pd, was prepared by a simple dissolution method. The chitosan and EDTA (1:1.5 by wt.) were dissolved in dilute acetic acid, then formed the beads, which were used to adsorb palladium(II) and finally reduced to palladium(0) by refluxing in ethanol. The as-prepared CS-EDTA-Pd was characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), and X-ray photoelectron spectroscopy (XPS). Then catalytic activities of the CS-EDTA-Pd catalyst were tested in the synthesis of biaryls from aryl halides and phenylboronic acid using the Suzuki–Miyaura cross-coupling reaction. The results have shown that the CS-EDTA-Pd was successfully applied as a catalyst for the Suzuki–Miyaura to couple aryl iodide and aryl bromide substrates under mild reaction conditions using ethanol as solvent and potassium carbonate as a base. The reactions at 80°C for 2 h under a normal atmosphere results in biaryls at good to excellent yields (>90%). This catalyst is inexpensive, simple to prepare, easy to separate from the reaction by filtration, and can be reused for five consecutive runs with a slight loss of product yields.

ประนอม แซ่จึง Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-12-01
    ชื่อวารสาร
  • Applied Organometallic Chemistry
    DOI
150 Superhydrophobic and superoleophiclic natural rubber latex foam coated by hexadecyltrimethoxysilane modified halloysite nanotube for oil/water separation Superhydrophobic and superoleophiclic natural rubber latex foam coated by hexadecyltrimethoxysilane modified halloysite nanotube for oil/water separation

In this research, we introduce a facile synthesis of the superhydrophobic natural rubber latex foam (NRLF), sponge-NRLF materials with a high oil-sorption capacity. The superhydrophobic sponge-NRLF was prepared by decorating the halloysite nanotubes (HNTS), which are chemically modified by n-hexadecyltrimethoxysilane (HDTMS) on the surface. The effects of HDTMS@HNTs loading and vulcanization systems towards the superhydrophobic and superhydrophilic properties of the NRLF were investigated. It was found that NRLF vulcanized by conventional vulcanization system (CV) and coated with 6 wt% HDTMS@HNTs showed favorable oil/water selectivity with excellent water repellence with a contact angle of 151°. The modified NRLF showed excellent performance toward gasoline 95 with high sorption capacity, achieving up to 10 times of its own weight for a wide range of oils. Oil sorption capacity tended to decline with respect to increasing HDTMS@HNTs content and oil viscosity due to the reduced porosity and surface area of the modified NRLF. Interestingly, the modified NRLF exhibited excellent durability, as the sorption efficiency remained unchanged after 10 cycles. Moreover, their fire retardant was also improved. 

สายันต์ แสงสุวรรณ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-12-01
    ชื่อวารสาร
  • Materials Today Communications
151 A cation-dipole-reinforced elastic polymer electrolyte enabling long-cycling quasi-solid-state lithium metal batteries A cation-dipole-reinforced elastic polymer electrolyte enabling long-cycling quasi-solid-state lithium metal batteries

The application of ionic liquids (IL) in polymer electrolytes represents a safer alternative to the currently used organic solvents in lithium batteries due to their nonflammability and thermal stability. However, as a plasticizer, it is generally agreed that the introduction of ionic liquid usually leads to a trade-off between ion transport and mechanical properties of polymer electrolyte. Here we report the synthesis of an IL-embedded polymer electrolyte with both high ionic conductivity (2.77 × 10−4 S cm−1 at room temperature) and excellent mechanical properties (high tensile strength up to 11.4 MPa and excellent stretchability of 387% elongation at break) achieved by strong ion–dipole interactions between polymer electrolyte components, which was unveiled by the DFT calculation. Moreover, this polymer electrolyte also exhibits nonflammability, good thermal stability and the ability to recover reversibly from applied stress, i.e., excellent elasticity. This highly viscoelastic polymer electrolyte enables tight interfacial contact and good adaptability with electrodes for stable lithium stripping/plating for 2000 h under a current density of 0.1 mA cm−2. By coupling with this polymer electrolyte, the LiFePO4/Li cells exhibit outstanding cycling stability at room temperature as well as the reliability under extreme environmental temperature or being abused.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-12-01
    ชื่อวารสาร
  • Journal of Energy Chemistry
152 A novel spirooxazine derivative as a colorimetric probe for Fe2+ and Pb2+ determination on microfluidic paper-based analytical device (μPAD) for maintaining in photochromic efficiency A novel spirooxazine derivative as a colorimetric probe for Fe2+ and Pb2+ determination on microfluidic paper-based analytical device (μPAD) for maintaining in photochromic efficiency

The synthesis of a novel spirooxazine (1-benzyl-3,3-dimethylspiro[indoline-2,3′-naphtho [2,1-b] [1,4] oxazine, BSP-SP) was developed as a colorimetric probe for the quantitative analysis of Fe2+ and Pb2+ in water samples. The device is based on a microfluidic paper-based analytical device (μPAD). BSP-SP was characterized by various techniques, e.g. single-crystal X-ray diffraction (SC-XRD) and time-dependent density functional theory (TD-DFT). In addition, the density functional theory (DFT) allowed us to understand better the adsorption of Fe2+ and Pb2+ over other cations adsorption on the BSP-MO structure. The structural isomerization of BSP-SP occurs as an open-form merooxazine (BSP-MO), which acts as a ligand to form Fe2+/BSP-MO and Pb2+/BSP-MO complexes. We observed these complexes under UV irradiation as having a light blue coloration. The μPADs were also proposed as detection platforms to maintain photostability and photochromic efficiency and extend the lifetime of the spirooxazine. Under optimal conditions, the developed μPAD enables rapid and sensitive quantitative analysis of Fe2+ at pH 6 and Pb2+ at pH 11. The limits of detection (LOD) were 0.036 mg L−1 for Fe2+ and 0.152 mg L−1 Pb2+. Overall, the developed sensors, particularly the μPADs, promise the practical analysis of Fe2+ and Pb2+ in water samples.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-12-01
    ชื่อวารสาร
  • Dyes and Pigments
153 Benzothiadiazole-based fluorophores as efficient non-doped emitters for solution-processed organic light-emitting diodes Benzothiadiazole-based fluorophores as efficient non-doped emitters for solution-processed organic light-emitting diodes

Hybridized local and charge-transfer (HLCT) is an attractive strategy for achieving efficient electroluminescence (EL) in electro-fluorescent devices, owing to the transformation of the triplet excited state (T) to the singlet excited state (S) via a reverse intersystem crossing that gives rise to a high exciton utilization efficiency exceeding the spin statistical limit. However, most efficient HLCT-based OLED devices are fabricated by high-cost vacuum deposition of the HLCT emitters. Herein, two new solution-processable HLCT fluorophores (CBFPhC and CBFTPA) based on benzothiadiazole (Bz) derivatives are designed and synthesized. The photoluminescence emissions of these two HLCT luminogens are experimentally and theoretically investigated using the solvatochromic effect and density functional theory calculations. Both molecules exhibit a high solubility, HLCT characteristics, and an intense yellow-green fluorescence with solid-state photoluminescence quantum yields of 77-79%. They are successfully employed as non-doped emissive layers in solution-processed double-layered OLEDs, which produce intense yellow-green emission colors with low turn-on voltages (3.0-3.2 V), high maximum luminescence (31 920 cd m−2), high maximum efficiencies (EQEmax = of 5.91%, PEmax = 13.29 lm W−1, and CEmax = 13.18 cd A−1), and decent efficiency low-off.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-11-02
    ชื่อวารสาร
  • New Journal of Chemistry
154 0 0

This study aimed to investigate grade-11 students’ conceptual understanding of chemical reaction rate through 5E inquiry approach in which they were asked to explore data for answering the engaged question using the small-scale syringe-vial experiment (SSVE) and elaborate their understanding using the AR interactive Particulate-level Visualization (ARiPV). The two-tier diagnostic conceptual test and semi-structured interview questions served as the data collection instruments. Thirty-three grade-11 students cooperated in the series of four 2-hour 5E learning activities for a total of 8 hours. Dependent samples T-test analysis showed that the mean score of the postconceptual test (mean 29.77, S.D. 6.77, 66.16%) was statistically greater than that of the preconceptual test (mean 11.68, S.D. 10.14, 25.96%) at the significance level of 0.05. Their actual gain was 40.20% and their normalized gain was 0.54, a medium increase. The majority of them moved from the less correct category, Partial Understanding with Specific Misunderstanding (PMU, 43.03%), to the more correct category, Partial Understanding (43.84%). The semi-structured interview showed that the 5E inquiry technique using SSVE in conjunction with ARiPV was entertaining and successful in identifying and enhancing their understanding. This demonstrated that this integrated intervention can encourage students to shift their conceptual understanding of reaction rate to the more advantageous categories.

ศักดิ์ศรี สุภาษร Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-11-01
    ชื่อวารสาร
  • Jurnal Pendidikan IPA Indonesia
    DOI
155 Multicomponent biodegradable hydrogels based on natural biopolymers as environmentally coating membrane for slow-release fertilizers: Effect of crosslinker type Multicomponent biodegradable hydrogels based on natural biopolymers as environmentally coating membrane for slow-release fertilizers: Effect of crosslinker type

This work aims to explore the suitable crosslinker type for synthesizing multicomponent biodegradable hydrogels of cassava starch (CSt) grafted with acrylic acid (AA) semi-interpenetrated by natural rubber (NR)/polyvinyl alcohol (PVA) blend (CSt-g-PAA/NR/PVA, CSB semi-IPN hydrogel) as coating membranes for slow-release urea fertilizers. Three crosslinker types (ethylene glycol dimethacrylate (EGDMA), glutaraldehyde (GA) and N,N′- methylene-bis-acrylamide (MBA)) were employed to investigate their influences on the properties of CSB semi-IPN hydrogels. The results revealed that the different crosslinkers clearly exhibited different water-retention capacity, biodegradation, slow release and plant growth performance of the CSB semi-IPN hydrogels. The CSB-G2 hydrogel (crosslinked with GA at 2 wt%) remained higher water-retention at 30 days (20.2 %), greater rate of degradation (1.37 %/day) and better biosafety (OD600 = 2.26) compared to CSB-M2 and CSB-E2 hydrogels. After urea pellets were coated by CSB hydrogels and wax layers (UCSBw formulation), the urea release rates from the UCSBw-M2, UCSBw-E2 and UCSBw-G2 formulations in 30 days were 67.7 %, 68.7 % and 78.3 %, respectively, corresponding well with swelling ratio and pore size. Besides, the UCSBw-G2 formulation yielded the greater plant growth performance (height, leaf length and product weight) than other two formulations and commercial fertilizer. In conclusion, GA is the suitable crosslinker for synthesizing the CSB-g-PAA/NR/PVA hydrogels with high water-retention, excellent biodegradation, less negative impact on environments, acceptable slow-release rate, good biosafety and reasonable price for slow-release fertilizers.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-10-15
    ชื่อวารสาร
  • Science of the Total Environment
156 Vanadium-Doped Porous Cobalt Oxide for Its Superior Peroxidase-like Activity in Simultaneous Total Cholesterol and Glucose Determination in Whole Blood Based on a Simple Two-Dimensional Paper-Based Analytical Device Vanadium-Doped Porous Cobalt Oxide for Its Superior Peroxidase-like Activity in Simultaneous Total Cholesterol and Glucose Determination in Whole Blood Based on a Simple Two-Dimensional Paper-Based Analytical Device

Vanadium-doped porous Co3O4 (V-porous Co3O4) was synthesized via a simple soft-templating method and used as a superior peroxidase mimic for the simultaneous colorimetric determination of glucose and total cholesterol (TC) in whole blood samples on a two-dimensional microfluidic paper-based analytical device (2D-μPAD). The large surface area and the presence of two metals in V-porous Co3O4 contributed to its excellent catalytic activity toward 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and 3,3′,5,5′- tetramethylbenzidine (TMB) with Michaelis-Menten constants (KM) of 0.1301 and 0.0141 mM, respectively. The 2D-μPAD was fabricated using simple wax screen-printing and cutting techniques. The colorimetric reactions of both glucose and TC on 2D-μPAD were simultaneously performed by adding a single drop of a whole blood sample on the sample zone made of the LF1 membrane. After the enzymatic reactions, the generated hydrogen peroxide (H2O2) was oxidized by V-porous Co3O4 to produce hydroxy radicals (•OH), inducing ABTS and TMB to generate colored products. The generated H2O2 was proportional to the intensities of the green and blue products of the glucose and TC systems, respectively. The developed 2D-μPAD required a short analysis time (∼5 min) with small volumes of samples (15 μL of whole blood) whereby no sample preparation was needed. Owing to several advantages including simplicity, low cost, long-term stability, and simultaneous readout, the novel V-porous Co3O4 coupled with 2D-μPAD proved to be promising for practical uses as a pioneering portable device for the determination of glucose, TC, and other important biomarkers without the need of technical supports.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-10-11
    ชื่อวารสาร
  • Analytical Chemistry
157 The Use of New Waste-Based Plasticizer Made from Modified Used Palm Oil for Non-Glutinous Thermoplastic Starch Foam The Use of New Waste-Based Plasticizer Made from Modified Used Palm Oil for Non-Glutinous Thermoplastic Starch Foam

A novel waste-based plasticizer derived from modified used palm oil (mUPO) was successfully developed and has been used as a new plasticizer to non-glutinous thermoplastic starch foam to improve their properties. The molecular weight and hydroxyl number of the mUPO was 3150 g/mol and 192.19 mgOH/g, respectively. The effects of mUPO content ranging from 0 to 9 phr were investigated. The results revealed that the optimal mUPO content as an additive was 6 wt%. The addition of mUPO had a direct effect on the mechanical properties and thermal properties. The impact strength increased from 1.30 to 4.55 J/m, while the glass transition temperature (Tg) decreased from 70.83 to 66.50 °C by increasing mUPO from 0 phr to 6 phr in the thermoplastic starch foam. The mUPO, on the other hand, has also the potential to reduce shrinkage from 33.91 to 21.77% and moisture absorption from 5.93 to 1.73% by increasing the content from 0 phr to 6 phr in starch foam. Furthermore, the mUPO helps the forming of the foam structure as measured by SEM, and the mUPO utilization of waste-based material could be a promising green alternative plasticizer for starch components, especially starch foam applications.

จุฑามาส จิตต์เจริญ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-10-01
    ชื่อวารสาร
  • Polymers
158 Facile and Compact Electrochemical Paper-Based Analytical Device for Point-of-Care Diagnostic of Dual Carcinogen Oxidative Stress Biomarkers through a Molecularly Imprinted Polymer Coated on Graphene Quantum-Dot Capped Gold Facile and Compact Electrochemical Paper-Based Analytical Device for Point-of-Care Diagnostic of Dual Carcinogen Oxidative Stress Biomarkers through a Molecularly Imprinted Polymer Coated on Graphene Quantum-Dot Capped Gold

Nanoscale imprinting significantly increases the specific surface area and recognition capabilities of a molecularly imprinted polymer by improving accessibility to analytes, binding kinetics, and template removal. Herein, we present a novel synthetic route for a dual molecularly imprinted polymer (dual-MIP) of the carcinogen oxidative stress biomarkers 3-nitrotyrosine (3-NT) and 4-nitroquinolin-N-oxide (4-NQO) as coatings on graphene quantum-dot capped gold nanoparticles (GQDs-AuNPs). The dual-MIP was successfully coated on the GQDs-AuNPs core via a (3-mercaptopropyl) trimethoxysilane (MPTMS) linkage and copolymerization with the 3-aminopropyltriethoxysilane (APTMS) functional monomer. In addition, we fabricated a facile and compact three-dimensional electrochemical paper-based analytical device (3D-ePAD) for the simultaneous determination of the dual biomarkers using a GQDs-AuNPs@dual-MIP-modified graphene electrode (GQDs-AuNPs@dual-MIP/SPGE). The developed dual-MIP device provides greatly enhanced electrochemical signal amplification due to the improved electrode-specific surface area, electrocatalytic activity, and the inclusion of large numbers of dual-imprinted sites for 3-NT and 4-NQO detection. Quantitative analysis used square wave voltammetry, with an oxidation current appearing at −0.10 V for 4-NQO and +0.78 V for 3-NT. The dual-MIP sensor revealed excellent linear dynamic ranges of 0.01 to 500 μM for 3-NT and 0.005 to 250 μM for 4-NQO, with detection limits in nanomolar levels for both biomarkers. Furthermore, the dual-MIP sensor for the simultaneous determination of 3-NT and 4-NQO provides high accuracy and precision, with no evidence of interference from urine, serum, or whole blood samples.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2022-11-22
    ชื่อวารสาร
  • Analytical Chemistry
159 0 0

We developed a novel, compact, three-dimensional electrochemical paper-based analytical device (3D-ePAD) for patulin (PT) determination. The selective and sensitive PT-imprinted Origami 3D-ePAD was constructed based on a graphene screen-printed electrode modified with manganese-zinc sulfide quantum dots coated with patulin imprinted polymer (Mn–ZnS QDs@PT-MIP/GSPE). The Mn–ZnS QDs@PT-MIP was synthesized using 2-oxindole as the template, methacrylic acid (MAA) as a monomer, N,N′-(1,2-dihydroxyethylene) bis (acrylamide) (DHEBA) as cross-linker and 2,2′-azobis (2-methylpropionitrile) (AIBN) as initiator, respectively. The Origami 3D-ePAD was designed with hydrophobic barrier layers formed on filter paper to provide three-dimensional circular reservoirs and assembled electrodes. The synthesized Mn–ZnS QDs@PT-MIP was quickly loaded on the electrode surface by mixing with graphene ink and then screen-printing on the paper. The PT-imprinted sensor provides the greatest enhancement in redox response and electrocatalytic activity, which we attributed to synergetic effects. This arose from an excellent electrocatalytic activity and good electrical conductivity of Mn–ZnS QDs@PT-MIP, which improved electron transfer between PT and the electrode surface. Under the optimized DPV conditions, a well-defined PT oxidation peak appears at +0.15 V (vs Ag/AgCl) using 0.1 M of phosphate buffer (pH 6.5) containing 5 mM K3Fe(CN)6 as the supporting electrolyte. Our developed PT imprinted Origami 3D-ePAD revealed excellent linear dynamic ranges of 0.001–25 μM, with a detection limit of 0.2 nM. Detection performance indicated that our Origami 3D-ePAD possesses outstanding detection performance from fruits and CRM in terms of high accuracy (%Error for inter-day is 1.11%) and precision (%RSD less than 4.1%). Therefore, the proposed method is well-suited as an alternative platform for ready-to-use sensors in food safety. The imprinted Origami 3D-ePAD is an excellent disposable device with a simple, cost-effective, and fast analysis, and it is ready to use for determining patulin in actual samples. 

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-09-01
    ชื่อวารสาร
  • Talanta
160 Styrene-assisted acrylic acid grafting onto polypropylene surfaces: preparation, characterization, and an automatically latex-coagulating application Styrene-assisted acrylic acid grafting onto polypropylene surfaces: preparation, characterization, and an automatically latex-coagulating application

This work aimed to modify the polypropylene (PP) surface by grafting with acrylic acid (AA) monomer in toluene solution using styrene (ST) and benzoyl peroxide (BPO) as comonomer and initiator, respectively, for potential application as an automatically latex-coagulating cup. The grafting percentage of PP-g-PAA was slightly increased with increasing time of surface activation, grafting reaction time, and concentrations BPO and AA. Interestingly, the presence of ST comonomer significantly improved the grafting percentage of AA onto PP sheets (PP-g-P(ST-co-AA)) and its ion exchange capacity from 5.76 to 25% and 8.87 × 10–5 to 43.1 × 10–5 meq/g, respectively. This indicated that the incorporation of ST could significantly enhance the grafting reaction of AA onto the PP surfaces. The possible mechanism of grafting reaction was also described and demonstrated. Besides, the PP-g-P(ST-co-AA)25 exhibited high coagulum performance of natural rubber latex (NRL) of 93.8% and high NRL coagulation rate of 63.5% %/h. Thus, the grafted PP with ST/AA monomers as an automatically latex-coagulating cup/container could offer not only the lower production cost and lesser environmental problems but also improved properties, qualities, and price of cup lump products.

ชัยวุฒิ วัดจัง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-05-01
    ชื่อวารสาร
  • Polymer Bulletin
161 Enhanced charge carrier density of a p-n BiOCl/BiVO4 heterostructure by Ni doping for photoelectrochemical applications Enhanced charge carrier density of a p-n BiOCl/BiVO4 heterostructure by Ni doping for photoelectrochemical applications

Pure and doped p-n BiOCl/BiVO4 heterostructures with various Ni contents were studied for photoanode applications in photoelectrochemical cells. All materials were synthesized by the coprecipitation method. The properties of the pure and doped materials were characterized by various techniques, such as X-ray diffraction, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, UV[sbnd]visible spectroscopy, and electrochemical impedance spectroscopy. Furthermore, density function theory calculations were employed to investigate the underlying physical mechanism of the Ni substitution. The materials were applied as the photoanode at an applied bias voltage of +1.9 V (vs. RHE) and irradiated over 4200 s under the solar light simulator. The pure p-n BiOCl/BiVO4 heterostructure showed the highest photocurrent of 1 mA/cm2. After 1% Ni doping, the photocurrent density was enhanced, and the highest photocurrent density was approximately 1.7 mA/cm2. From the theoretical calculation aspect, the role of Ni substitution into the parent p-n BiVO4 and BiOCl materials resulted in a surface state under the conduction band of both parent materials. The result was in agreement with the Mott-Schottky analysis, which showed that the charge carrier density increased as Ni atoms were added to the p-n BiOCl/BiVO4 heterostructure. Therefore, the additional state and the increase in the charge carrier density led to the improved photocatalytic activity of the Ni-doped p-n BiOCl/BiVO4 heterostructure. © 2022 Elsevier B.V.

นุชนาพร พิจารณ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-03-15
    ชื่อวารสาร
  • Journal of Alloys and Compounds
162 Origami 3D-microfluidic paper-based analytical device for detecting carbaryl using mesoporous silica-platinum nanoparticles with a molecularly imprinted polymer shell Origami 3D-microfluidic paper-based analytical device for detecting carbaryl using mesoporous silica-platinum nanoparticles with a molecularly imprinted polymer shell

Herein, we present a novel Origami 3D-μPAD for colorimetric carbaryl detection using a super-efficient catalyst, namely mesoporous silica-platinum nanoparticles coated with a molecularly imprinted polymer (MSN-PtNPs@MIP). Morphological and structural characterization reveals that coating MIP on the MSN-PtNPs surface significantly increases the selective area, leading to larger numbers of imprinting sites for improved sensitivity and selectivity in determining carbaryl. The as-prepared MSN-PtNPs@MIP was used for catalytic oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2. Carbaryl selectively binds to the cavities embedded on the MSN-PtNPs surface and subsequently inhibits TMB oxidation leading the color to change to light blue. The change of reaction color from dark blue to light blue depends on the concentration of carbaryl within the 3D-μPAD detection zone. This design integrates the advantages of highly efficient sample delivery through micro channels (top layer) and efficient partition/separation paths (bottom layer) of the cellulose substrate to achieve both improved detection sensitivity and selectivity. Assay on the Origami 3D-μPAD can determine carbaryl by ImageJ detection, over a dynamic range of 0.002–20.00 mg kg−1, with a very low limit of detection at 1.5 ng g−1. The developed 3D-μPAD exhibit high accuracy when applied to detect carbaryl in fruits, with satisfactory recoveries from 90.1% to 104.0% and relative differences from the reference HPLC values less than 5.0%. Furthermore, the fabricated Origami 3D-μPAD provides reliable durability and good reproducibility (3.19% RSD for fifteen devices). 

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-03-01
    ชื่อวารสาร
  • Talanta
163 Rapid synthesis and optimization of UV-photopolymerized cassava starch-based superabsorbent hydrogels as a biodegradable, low-cost, and effective adsorbent for MB removal Rapid synthesis and optimization of UV-photopolymerized cassava starch-based superabsorbent hydrogels as a biodegradable, low-cost, and effective adsorbent for MB removal

In this work, eco-friendly superabsorbent hydrogel (SAH) films based on cassava starch (CSt) and polyacrylic acid (PAA) were successfully fabricated and optimized via a one-pot synthesis and UV-photopolymerization under an air atmosphere to obtain the highest swelling ratio (Seq) and to be employed as an effective adsorbent for removing methylene blue (MB). The optimal CSt-g-PAA film exhibited uniform porous structures with a high specific surface area (24.99 m2/g), acceptable Young’s modulus (60.9 MPa), and a relatively high Seq value (35,645% or 356 g/g). It also revealed selective adsorption toward MB dye. The adsorption process of MB onto CSt-g-PAA SAH followed the pseudo-second-order and Langmuir isotherm models. The maximum adsorption capacity (qm), partition coefficient (PC), and removal efficiency for MB adsorption were evaluated to be 1,044 mg/g, 4.08 mg/g.µM−1, and 95%, respectively, making the CSt-g-PAA SAH film one of the most efficient starch-based adsorbents for MB removal. Thermodynamic studies indicated spontaneous and endothermic adsorption. The plausible adsorption mechanism was mainly described by electrostatic interaction and hydrogen bonding. Furthermore, the prepared CSt-g-PAA SAH film displayed excellent reusability, remarkable biodegradability, good biosafety, and low cost. Therefore, it may be a promising and sustainable adsorbent for removing dye pollutants and enhancing the ecosystem.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-02-25
    ชื่อวารสาร
  • Journal of Industrial and Engineering Chemistry
164 A paper chromatographic-based electrochemical analytical device for the separation and simultaneous detection of carbofuran and carbaryl pesticides A paper chromatographic-based electrochemical analytical device for the separation and simultaneous detection of carbofuran and carbaryl pesticides

We developed an electrochemical paper-based device (ePAD) for the online separation and simultaneous determination of structurally similar carbofuran (CBF) and carbaryl (CBR). Our device combined paper chromatography and an electrochemical sensor as a single system for increasing the selectivity to simultaneous detection of the two pesticides. During the simultaneous detection of CBF and CBR, the separation of the two carbamate compounds depends on the differences between the movements of the substances on the chromatographic paper in the moving phase flow. The isolated pesticides were electrochemically measured using an amperometric method. Under optimal conditions, which include the effect of the mobile phase, separation channel, and the applied potential, the proposed device provides a linear range for the simultaneous determination of CBF and CBR from 0.1 to 2.0 and 0.5–7.5 mg L−1, with the limits of detection at 0.06 and 0.40 mg L−1, respectively. Furthermore, we successfully used the developed device to determine CBF and CBR in water, cucumber, and cabbage samples. The obtained results correspond to results obtained from a standard method. This developed ePAD is low-cost and uses a low sample volume (2 µL). Moreover, it is disposable, portable, and a promising tool for the on-site quantification of pesticides in actual samples.

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-02-15
    ชื่อวารสาร
  • Sensors and Actuators B: Chemical
165 Mechanistic insights into the self-esterification of lactic acid under neutral and acidic conditions Mechanistic insights into the self-esterification of lactic acid under neutral and acidic conditions

Lactic acid (LA) is frequently used as the starting material for the production of biodegradable and/or bio-compatible polymers. We study several mechanisms which have been envisaged as important for the formation of lactide (LT, the cyclic diester of LA) in toluene solutions, both under neutral and acidic conditions. Quantum mechanical calculations of molecules and aggregates have been performed at the DFT level. We determine the free energies and molecular geometries of the reactants, products, the transition states, and intermediates. Among many proposed mechanisms, we confirm that, under neutral conditions, there is no promising reaction at the prevailing experimental conditions. This is to a large extent due to entropic effects. Under acidic conditions, on the other hand, both initial conversion of LA to dimers and the subsequent conversion to lactide will proceed, in particular if additional LA molecules are available (asynchronous concerted trimolecular reaction). However, to be selective towards LT, the systems should not contain an excess of LA, a condition that could be met in suitable porous media. 

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-02-05
    ชื่อวารสาร
  • Journal of Molecular Structure
166 Mechanistic insights into hydrogen production from formic acid catalyzed by Pd@N-doped graphene: The role of the nitrogen dopant Mechanistic insights into hydrogen production from formic acid catalyzed by Pd@N-doped graphene: The role of the nitrogen dopant

The catalytic decomposition of formic acid (HCOOH) is a crucial process for hydrogen production technologies. Herein, periodic density functional theory (DFT) calculations were employed to explore the effect of N-doping on the decomposition of formic acid. We designed a series of single Pd-atoms deposited in the single vacancy of N-doped graphene sheets, namely Pd-DGr, Pd–N1Gr, Pd–N2Gr, and Pd–N3Gr, as the proposed catalysts. Our findings show that H2 production from HCOOH dehydrogenation on these surfaces proceeds via the formate (HCOO) pathway (Path-I) rather than the carboxylate (COOH) pathway (Path-II). Furthermore, the Pd–N3Gr catalyst shows the greatest catalytic reactivity toward HCOOH dehydrogenation via Path-I, requiring an activation energy (Ea) of 0.38 eV. On the other hand, the undesirable dehydration of HCOOH to carbon monoxide (CO) through COOH (Path-IIIA) or formyl (HCO) (Path-IIIB) intermediates is unlikely to occur on Pd–N3Gr due to a large activation energy. We found that the active species on the catalyst surface increased with N-doping concentration. Additionally, microkinetic simulations of the HCOOH decomposition on these surfaces confirmed the high activity and selectivity of the Pd–N3Gr catalyst toward HCOOH dehydrogenation (Path-I). These calculated results highlight that the Pd–N3Gr catalyst is a promising candidate for the formic acid decomposition reaction to yield hydrogen.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-01-31
    ชื่อวารสาร
  • International Journal of Hydrogen Energy
167 Structure-based drug design of novel M. tuberculosis InhA inhibitors based on fragment molecular orbital calculations Structure-based drug design of novel M. tuberculosis InhA inhibitors based on fragment molecular orbital calculations

2-trans enoyl-acyl carrier protein reductase (InhA) is a promising target for developing novel chemotherapy agents for tuberculosis, and their inhibitory effects on InhA activity were widely investigated by the physicochemical experiments. However, the reason for the wide range of their inhibitory effects induced by similar agents was not explained by only the difference in their chemical structures. In our previous molecular simulations, a series of heteroaryl benzamide derivatives were selected as candidate inhibitors against InhA, and their binding properties with InhA were investigated to propose novel derivatives with higher binding affinity to InhA. In the present study, we extended the simulations for a series of 4-hydroxy-2-pyridone derivatives to search widely for more potent inhibitors against InhA. Using ab initio fragment molecular orbital (FMO) calculations, we elucidated the specific interactions between InhA residues and the derivatives at an electronic level and highlighted key interactions between InhA and the derivatives. The FMO results clearly indicated that the most potent inhibitor has strong hydrogen bonds with the backbones of Tyr158, Thr196, and NADH of InhA. This finding may provide informative structural concepts for designing novel 4-hydroxy-2-pyridone derivatives with higher binding affinity to InhA. Our previous and present molecular simulations could provide important guidelines for the rational design of more potent InhA inhibitors.

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-01-01
    ชื่อวารสาร
  • Computers in Biology and Medicine
168 Sesquiterpenoids and sesquiterpenoid dimers from the stem bark of Dysoxylum parasiticum (osbeck) kosterm Sesquiterpenoids and sesquiterpenoid dimers from the stem bark of Dysoxylum parasiticum (osbeck) kosterm

Two undescribed sesquiterpenoids, namely dysoticans A and B, and three undescribed sesquiterpenoid dimers, namely dysoticans C-E, together with six analogs, were isolated from the stem bark of Dysoxylum parasiticum (Osbeck) Kosterm. (Meliaceae), growing in West Java, Indonesia. Their structures were elucidated based on extensive spectroscopic analysis and theoretical simulations of ECD spectra and 13C NMR shifts. Dysoticans A and B possessed undescribed cadinanes with minor modifications, while C and D featured unprecedented pseudo-sesquiterpenoid dimers through O-ether linkages of cadinanes and guaianes, respectively. Dysotican E was also characterized as the true-sesquiterpenoid dimer featuring eudesmane-germacrene hybrid framework from the Meliaceae family. Furthermore, A-C and E showed moderate activities against the human breast cancer MCF-7 and cervical cancer HeLa cell lines with IC50 values ranging from 22.15 to 45.14 μM. D selectively exhibited significant cytotoxicity against the HeLa cell line with an IC50 value of 13.00 ± 0.13 μM. © 2022 Elsevier Ltd

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-01-01
    ชื่อวารสาร
  • Phytochemistry
169 Mickey mouse-shaped laminated paper-based analytical device in simultaneous total cholesterol and glucose determination in whole blood Mickey mouse-shaped laminated paper-based analytical device in simultaneous total cholesterol and glucose determination in whole blood

The microfluidic paper-based analytical device (μPAD) platform is gaining attention as a low-cost, portable, and disposable detection tool. However, the limitations of traditional fabrication methods include poor reproducibility and the use of hydrophobic reagents. In this study, an in-house computer-controlled X–Y knife plotter and pen plotter were used to fabricate μPADs, resulting in a simple, more rapid, reproducible process that consumes less volume of reagents. The μPADs were laminated to increase mechanical strength and reduce sample evaporation during analysis. The resulting laminated paper-based analytical device (LPAD) was used to simultaneously determine glucose and total cholesterol in whole blood using the LF1 membrane as a sample zone. The LF1 membrane selectively separates plasma from whole blood by size exclusion and yields plasma for further enzymatic reaction steps while retaining blood cells and larger proteins. The i1 Pro 3 mini spectrophotometer directly detected color on the LPAD. The results were clinically relevant and in agreement with hospital methods, with a detection limit of 0.16 mmol L⁻1 for glucose and 0.57 mmol L⁻1 for TC. The LPAD retained color intensity after 60 days of storage. The LPAD offers a low-cost, high-performance option for chemical sensing devices and expands the applicability of markers for diagnosing whole blood samples.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-07-04
    ชื่อวารสาร
  • Analytica Chimica Acta
170 Visual detection of formalin in food samples by using a microfluidic thread-based analytical device Visual detection of formalin in food samples by using a microfluidic thread-based analytical device

The use of formalin (FA) to maintain food freshness and storage time is illegal. FA intake causes chronic and acute effects on human health. In this work, the novel visual detection of FA in food samples by using a microfluidic thread-based analytical device (µTAD) was developed. This proposed method based on a sulfite assay where FA reacted with excess Na2SO3 to generate NaOH that was quantified on µTAD using acid-base titration. The µTAD was fabricated from an untreated 100 % cotton thread (20.0 cm) treated with phenolphthalein solution as an indicator and low and high concentrations of Potassium hydrogen phthalate (KHP) as a limiting agent. Both threads were tied together with a central knot before being attached to the woodblock platform before the analysis. The length of the color change (colorless to pink) on the µTAD was analyzed by the visual detection using the digital vernier caliper and ImageJ software (mode: distance measurement) using a captured image from a smartphone. Two linear calibration curves at low concentration (150–350 mg L−1) and high concentration (500–900 mg L−1) were achieved with the limit of quantification at 150 mg L−1. In addition, greater selectivity towards FA compared with potential interference ions was also observed. Furthermore, the developed µTAD was applied to analyze FA in food samples, and the results was agree with those obtained by the conventional method. Thus, the proposed µTAD can be used for developing a colorimetric detection platform for interesting trace chemical analysis. 

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-07-01
    ชื่อวารสาร
  • Microchemical Journal
171 A Mechanistic Study on Homo- and Copolymerization of L-Lactide and Ε-Caprolactone Catalyzed by an Aluminum Complex Bearing a Bis(Phenoxy)Amine Ligand: A Dft Study A Mechanistic Study on Homo- and Copolymerization of L-Lactide and Ε-Caprolactone Catalyzed by an Aluminum Complex Bearing a Bis(Phenoxy)Amine Ligand: A Dft Study

Polymerization of biodegradable lactide and lactones has been the subject of intense research during the past decade. We used density functional theory (DFT) calculations to investigate the initiation and first propagation for ring-opening polymerization (ROP) of L-lactide (LA) and ε-caprolactone (CL) on aluminum complexes bearing the bis(phenoxy)-amine ligand with pyridine (complex I) and diethylamine (complex II) sidearm. Our findings show that the rate-determining steps (RDS) for the ROP reaction of LA and CL are the nucleophilic attack on the carbonyl carbon of the monomer. The LA insertion provided a more thermodynamically stable product in all cases. Furthermore, the homopolymerization of CL on both complexes can occur more favorably than for LA. Therefore, we predict that complex I will have a greater LA homopolymerization rate than complex II. On the other hand, the amine sidearm variation of complexes I and II showed the difference in activities toward LA and CL copolymerization, producing various copolymer types. These calculated results are in good agreement with our previous experimental reports. The understanding gained in the current study might be helpful in the development of high-performance catalysts for the ROP reaction of biodegradable lactide and lactones

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-06-18
    ชื่อวารสาร
  • Polymer
172 A novel immunosensor based on cobalt oxide nanocomposite modified single walled carbon nanohorns for the selective detection of aflatoxin B1 A novel immunosensor based on cobalt oxide nanocomposite modified single walled carbon nanohorns for the selective detection of aflatoxin B1

We developed a novel, sensitive, and selective platform for the specific determination of aflatoxin B1 (AFB1). Single-walled carbon nanohorns decorated by a cobalt oxide composite and gold nanoparticles were created to provide facile electron transfer and improve the sensor's sensitivity. In addition, we attributed the selectivity of the proposed sensor to the specific binding property of the anti-aflatoxin B1 antibody. We clarified the specific interaction of the proposed immunosensor to AFB1 using homology modeling combined with molecular docking. In the presence of AFB1, the current signal of the modified electrode reduced; this involved specific antibody-antigen binding, including hydrophobic hydrogen bonding and pi-pi stack interactions. The new AFB1 sensor platform showed two linearity ranges of 0.01–1 ng mL−1 and 1–100 ng mL−1, with the limit of detection at 0.0019 ng mL−1. We investigated the proposed immunosensor in real samples, including peanuts, certified reference material of a peanut sample (labeled 206 μg kg−1 AFB1), corn, and chicken feed. The sensor's accuracy was 86.1–104.4% recovery, which agrees with the reference HPLC technique using paired t-test analysis. The present work shows excellent performance for AFB1 detection and could be applied for food quality control or modified to detect other mycotoxins. 

อัญชลี สำเภา Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-06-01
    ชื่อวารสาร
  • Talanta
173 Simple colorimetric assay using pectin hydrogel reagent coupled with camera-based photometry for trace arsenic determination Simple colorimetric assay using pectin hydrogel reagent coupled with camera-based photometry for trace arsenic determination

Humans mainly ingest arsenic through contaminated drinking water, causing serious health effects. The World Health Organization (WHO) has set the permissible limit of arsenic in drinking water at 0.01 mg/L and concentrations should be regularly determined to ensure a safe supply. In this study, a leucomalachite green (LMG) pectin-based hydrogel reagent was prepared that selectively reacted with arsenic over other metals including manganese, copper, lead, iron, and cadmium. Pectin, optimized at 0.2% (w/v), was used to form the hydrogel matrix. Arsenic reacts with potassium iodate in sodium acetate buffer medium to liberate iodine that then oxidizes LMG entrapped in pectin hydrogel to form a blue product. Camera-based photometry/ImageJ software was used to monitor the color intensity, eliminating the need for a spectrophotometer. The intensity of gray in the red channel was chosen as optimal for the red, green, and blue (RGB) analysis. The colorimetric assay revealed a dynamic detection range toward arsenic solution standards of 0.003–1 mg/L, covering the WHO recommendation of below 0.01 mg/L arsenic in drinking water. The assay gave recovery rates between 97 and 109% at a 95% confidence interval, with precision of 4–9%. Concentrations of arsenic in the spiked drinking water, tap water, and pond water samples monitored by the developed method agreed well with conventional inductively coupled plasma optical emission spectrometry. This assay showed promise for on-site quantitative analysis of arsenic in water samples. Graphical Abstract: [Figure not available: see fulltext.]

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-05-25
    ชื่อวารสาร
  • Analytical and Bioanalytical Chemistry
174 Mechanistic insights into hydrogen production from formic acid catalyzed by Pd@N-doped graphene: The role of the nitrogen dopant Mechanistic insights into hydrogen production from formic acid catalyzed by Pd@N-doped graphene: The role of the nitrogen dopant

The catalytic decomposition of formic acid (HCOOH) is a crucial process for hydrogen production technologies. Herein, periodic density functional theory (DFT) calculations were employed to explore the effect of N-doping on the decomposition of formic acid. We designed a series of single Pd-atoms deposited in the single vacancy of N-doped graphene sheets, namely Pd-DGr, Pd–N1Gr, Pd–N2Gr, and Pd–N3Gr, as the proposed catalysts. Our findings show that H2 production from HCOOH dehydrogenation on these surfaces proceeds via the formate (HCOO) pathway (Path-I) rather than the carboxylate (COOH) pathway (Path-II). Furthermore, the Pd–N3Gr catalyst shows the greatest catalytic reactivity toward HCOOH dehydrogenation via Path-I, requiring an activation energy (Ea) of 0.38 eV. On the other hand, the undesirable dehydration of HCOOH to carbon monoxide (CO) through COOH (Path-IIIA) or formyl (HCO) (Path-IIIB) intermediates is unlikely to occur on Pd–N3Gr due to a large activation energy. We found that the active species on the catalyst surface increased with N-doping concentration. Additionally, microkinetic simulations of the HCOOH decomposition on these surfaces confirmed the high activity and selectivity of the Pd–N3Gr catalyst toward HCOOH dehydrogenation (Path-I). These calculated results highlight that the Pd–N3Gr catalyst is a promising candidate for the formic acid decomposition reaction to yield hydrogen.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-05-19
    ชื่อวารสาร
  • International Journal of Hydrogen Energy
175 Bioisosteric Design Identifies Inhibitors of Mycobacterium tuberculosis DNA Gyrase ATPase Activity Bioisosteric Design Identifies Inhibitors of Mycobacterium tuberculosis DNA Gyrase ATPase Activity

Mutations in DNA gyrase confer resistance to fluoroquinolones, second-line antibiotics for Mycobacterium tuberculosis infections. Identification of new agents that inhibit M. tuberculosis DNA gyrase ATPase activity is one strategy to overcome this. Here, bioisosteric designs using known inhibitors as templates were employed to define novel inhibitors of M. tuberculosis DNA gyrase ATPase activity. This yielded the modified compound R3-13 with improved drug-likeness compared to the template inhibitor that acted as a promising ATPase inhibitor against M. tuberculosis DNA gyrase. Utilization of compound R3-13 as a virtual screening template, supported by subsequent biological assays, identified seven further M. tuberculosis DNA gyrase ATPase inhibitors with IC50 values in the range of 0.42-3.59 μM. The most active compound 1 showed an IC50 value of 0.42 μM, 3-fold better than the comparator ATPase inhibitor novobiocin (1.27 μM). Compound 1 showed noncytotoxicity to Caco-2 cells at concentrations up to 76-fold higher than its IC50 value. Molecular dynamics simulations followed by decomposition energy calculations identified that compound 1 occupies the binding pocket utilized by the adenosine group of the ATP analogue AMPPNP in the M. tuberculosis DNA gyrase GyrB subunit. The most prominent contribution to the binding of compound 1 to M. tuberculosis GyrB subunit is made by residue Asp79, which forms two hydrogen bonds with the OH group of this compound and also participates in the binding of AMPPNP. Compound 1 represents a potential new scaffold for further exploration and optimization as a M. tuberculosis DNA gyrase ATPase inhibitor and candidate anti-tuberculosis agent. 

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-05-08
    ชื่อวารสาร
  • Journal of Chemical Information and Modeling
176 0 0

We successfully developed a fluorometric paper-based test kit for the selective and sensitive determination of cyanide using nitrogen-doped graphene quantum dots (N-GQDs) as the fluorescent probe. Citric acid and tris(hydroxymethyl)aminomethane were precursors for the one-step synthesis of N-GQDs via in situ hydrothermal methods, providing a high quantum yield of 57.9%. The proposed mechanism uses a fluorescence turn-on approach. Specifically, the fluorescence of N-GQDs is quenched by the incorporation of Ag+ via a photoinduced electron transfer (PET). During the detection step, sulfuric acid converts cyanide (CN-) into hydrogen cyanide (HCN). The Ag+ species on the N-GQD surface then react with the evolved HCN via a coordination bond to form a silver cyanide complex, resulting in the fluorescence emission of the N-GQDs being turned back on. As a result, the fluorescence emission intensity of N-GQDs linearly increased with increasing CN- concentrations in the range of 0.5-25 mg L-1, with a limit of detection (LOD) of 0.08 mg L-1. Notably, the developed sensor has advantages in terms of simplicity, rapidity, low cost, and high selectivity toward CN-. The analytical performance of the test kit was also validated the performance of the test kit against a conventional precipitation titration method. 

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-04-17
    ชื่อวารสาร
  • ACS Applied Nano Materials
177 Physicochemical investigation of the enhanced removal of methylene blue from aqueous solution using polydopamine/silver nanoparticles Physicochemical investigation of the enhanced removal of methylene blue from aqueous solution using polydopamine/silver nanoparticles

Polydopamine/Ag (PDA/Ag) nanoparticles were synthesized for methylene blue (MB) removal from aqueous solution as a model dye. These particles were prepared in a modified literature procedure in which polydopamine (PDA) nanoparticles were first prepared via the oxidative polymerization of dopamine (DA) under alkaline conditions in the presence of oxygen. Subsequently, nanoparticulate PDA/Ag was accessed from direct reduction of silver precursor [Ag(NH3)2]+ ions by catechol amino groups in the PDA structure to form Ag nanoparticles (AgNPs) fixed on the PDA surface. Confirmation of the formation of the PDA and PDA/Ag nanoparticles, plus characterization of their surface morphologies was achieved. In the MB adsorption studies, the various factors affecting the dye adsorption and thermodynamic parameters were investigated in detail. This adsorption process can be described well by the Langmuir model. In order to gain a deeper molecular insight into this process, we investigated some possible local model structures of PDA/Ag nanoparticles and MB interaction with these structures using density functional theory (DFT) calculations. The results indicated that the adsorption energies (E ads) of MB on the PDA/Ag nanoparticles were higher than the E ads of MB on PDA nanoparticles, which was consistent with the experimental results. Our results provide a significant new finding for the role of Ag nanoparticles in the MB adsorption process on PDA/Ag nanoparticles. Readily accessible nanoparticulate PDA/Ag was shown to be a highly effective adsorbent for MB from aqueous solution and thus has significant potential for applications in wastewater dye removal.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-03-24
    ชื่อวารสาร
  • Journal of the Textile Institute
178 Talarostatin, a vermistatin derivative from the soil-derived fungus Talaromyces thailandensis PSU-SPSF059 Talarostatin, a vermistatin derivative from the soil-derived fungus Talaromyces thailandensis PSU-SPSF059

The soil-derived fungus Talaromyces thailandensis PSU-SPSF059 produced one new vermistatin derivative, talarostatin, and seven known compounds including two vermistatins, two chrodrimanins, two diphenyl ethers and one penicillide derivative. Extensive spectroscopic analysis was performed to identify their structures. The absolute configuration of talarostatin was determined by comparing the experimental and calculated electronic circular dichroism data. The antimicrobial and cytotoxic activities of the isolated secondary metabolites were also evaluated. 

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-03-15
    ชื่อวารสาร
  • Natural Product Research
179 0 0

Palladium catalyst supported on chitosan-EDTA composite, CS-EDTA-Pd, was prepared by a simple dissolution method. The chitosan and EDTA (1:1.5 by wt.) were dissolved in dilute acetic acid, then formed the beads, which were used to adsorb palladium(II) and finally reduced to palladium(0) by refluxing in ethanol. The as-prepared CS-EDTA-Pd was characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDX), and X-ray photoelectron spectroscopy (XPS). Then catalytic activities of the CS-EDTA-Pd catalyst were tested in the synthesis of biaryls from aryl halides and phenylboronic acid using the Suzuki–Miyaura cross-coupling reaction. The results have shown that the CS-EDTA-Pd was successfully applied as a catalyst for the Suzuki–Miyaura to couple aryl iodide and aryl bromide substrates under mild reaction conditions using ethanol as solvent and potassium carbonate as a base. The reactions at 80°C for 2 h under a normal atmosphere results in biaryls at good to excellent yields (>90%). This catalyst is inexpensive, simple to prepare, easy to separate from the reaction by filtration, and can be reused for five consecutive runs with a slight loss of product yields.

ประนอม แซ่จึง Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-03-01
    ชื่อวารสาร
  • Applied Organometallic Chemistr
180 0 0

An asymmetrical true-dimeric cadinane via ketonic bridge [C-15/C-3′], dysotican F (1), two symmetrical pseudo-cadinane dimers through an O-ether linkage [C-3/C-3′], dysoticans G (2) and H (3), as well as three known sesquiterpenoids 4–6 were obtained from the stem bark of Dysoxylum parasiticum (Osbeck) Kosterm. (Meliaceae). Their structures were determined by spectroscopic and quantum chemical calculations of 13C NMR shifts using a GIAO method and electronic circular dichroism (ECD) using a TDDFT method. A possible biogenetic pathway for 1–3 beginning from the known compounds (i–ii) was proposed. Cytotoxic evaluation showed that 2 as a new lead compound is the most potent against the MCF-7 and HeLa cell lines with IC50 values of 12.07 ± 0.17 μM and 9.29 ± 0.33 μM, while 1 has moderate inhibition with IC50 values of 31.59 ± 0.34 μM and 27.93 ± 0.25 μM. Furthermore, 3 is a selective inhibitor against the HeLa cell growth with an IC50 value of 39.72 ± 0.18 μM. A brief structure–activity relationship analysis of all isolated compounds 1–6 was also provided, including comparison with the coexisting molecules in the previous report.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-03-01
    ชื่อวารสาร
  • RSC Advances
181 Facile surface-controlled synthesis of phytic acid-facilitated calcium carbonate composites for highly efficient ferric ion adsorption and recovery from rust Facile surface-controlled synthesis of phytic acid-facilitated calcium carbonate composites for highly efficient ferric ion adsorption and recovery from rust

This work presents a simple synthesis of calcium carbonate (CaCO3)-based composites designed for the efficient adsorption of ferric ions (Fe3+) from solution, and specifically applied for Fe3+ recovery from rust. The strategy involves coordinating phytic acid (PA) with calcium ions (Ca2+) and coprecipitation with carbonate ions (CO32−) at room temperature to form phytate-CaCO3 (Ph-CC) composites. The obtained composites exhibited a robust mesoporous crystal structure with numerous phosphate groups of phytate functionalized on CaCO3 microparticles. The surface properties of the composites were optimized by adjusting the molar ratio (x) of PA:Ca2+ in synthesis. The Ph-CC0.10 composite (x = 0.10), with the highest specific surface area (99.56 m2/g), demonstrated exceptional Fe3+ adsorption (>99% efficiency in 80 min). The adsorption process followed the pseudo-second-order and Langmuir isotherm models, indicating monolayer coverage. Impressively, the maximum adsorption capacity reached 1385.85 mg/g, surpassing that of previously reported adsorbents. Thermodynamic studies confirmed a spontaneous and exothermic adsorption process. The superior Fe3+ adsorption of the composite was attributed to electrostatic and chelation interactions, with partial ion exchange. Furthermore, the Ph-CC0.10 composite effectively captured Fe3+ from rust dissolution in an acidic solution (pH 3) under sonication at 35 kHz for 60 min. These results highlight the potential use of the developed composites in mitigating environmental pollution and transforming waste materials into valuable sources. Therefore, Ph-CC composites are promising alternatives for wastewater treatment and metallurgical applications.

เกษริน สีบุญเรือง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-12-01
    ชื่อวารสาร
  • Materials Today Sustainability
182 Asymmetric Crosslinked Polyacrylamide/Natural Rubber Semi-IPN Hydrogel for Application of Methyl Orange Dye Removal: Combined Experimental and DFT Study Asymmetric Crosslinked Polyacrylamide/Natural Rubber Semi-IPN Hydrogel for Application of Methyl Orange Dye Removal: Combined Experimental and DFT Study

This study presents a combined experimental and density functional theory (DFT) investigation into the synthesis and characterization of the polyacrylamide/natural rubber (pAAm/NR) semi-interpenetrating polymer network (semi-IPN) hydrogel crosslinked with allyl methacrylate as an asymmetric crosslinker. Employing 2,2-Azobis 2-methylpropionamidine dihydrochloride (V50 azo) as the initiator, the hydrogel was designed for the efficient removal of methyl orange (MO) dye from aqueous solutions. Prepared through free radical polymerization, the properties of hydrogel encompassing morphology, water absorption, and MO adsorption were examined. FTIR analysis confirmed the semi-IPN structure, featuring functional groups from NR and AAm. SEM images revealed the presence of a porous matrix characterized by interconnected pores of various sizes. Importantly, the efficiency of MO adsorption exhibited a direct correlation with the NR content, culminating in an impressive adsorption capacity of 806.61 mg/g at the AAm/NR ratio of 90/10 for 20 h. The fitting of experimental data corresponding to the 90/10 AAm/NR ratio to theoretical adsorption isotherms consistently suggested a monolayer adsorption mechanism of MO on a homogeneous surface, involving both physisorption and chemisorption. Moreover, DFT results supported experimental findings, indicating more favorable MO adsorption on the pAAm molecule (Eads = − 1.97 eV) than the NR molecule (Eads = − 0.80 eV). In conclusion, the pAAm/NR Semi-IPN Hydrogel, especially at the 90/10 ratio, exhibited strong potential for MO dye removal. These unique hydrogel attributes and efficient MO adsorption capacity suggest promising applications in environmental remediation and wastewater treatment.

จุฑามาส จิตต์เจริญ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-11-10
    ชื่อวารสาร
  • Journal of Polymers and the Environment
183 Enhanced Electrocatalytic CO2 Reduction Reactivity of S- and N-Doped Fe-Embedded Graphene Enhanced Electrocatalytic CO2 Reduction Reactivity of S- and N-Doped Fe-Embedded Graphene

In this work, we studied the reaction mechanisms for CO2 reduction reaction (CRR) on the iron-doped graphene and its coordinating sulfur (S) and nitrogen (N) variants, FeNnS4-n (n=1–4), using density functional theory calculations. Our results revealed that the electronic property and catalytic reactivity of the surfaces can be tuned by varying the N and S atoms ratio. The CRR activities of the mixed surfaces, FeN3S1, FeN2S2, and FeN1S3, were better than FeN4 and FeS4, where the absolute value of the limiting potential of the mixed surface decreased by 0.3 V. Considering the stability, we suggest FeN3S surface to be favorable for CRR. For the bare surfaces, we found a positive linear correlation between the magnetic moment and the charge of Fe metal. For these surfaces, the reduction of CO (*CO+(H++e)→*CHO) was important in deciding the limiting potential. We found that the adsorption energy of CO displayed a volcano relationship with the magnetic moment of the Fe atom. The study showed that the change of local coordinating structure around the Fe atom could modify the electronic and magnetic properties of the active Fe center and improve the CRR activity performance.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-11-01
    ชื่อวารสาร
  • ChemPlusChem
184 Enhanced hydrogen evolution reaction performance of anatase-rutile TiO2 heterojunction via charge transfer from rutile to anatase Enhanced hydrogen evolution reaction performance of anatase-rutile TiO2 heterojunction via charge transfer from rutile to anatase

In light of recent doubts surrounding the industrial viability of photo(electro)catalysis technology for sustainable hydrogen production, it becomes imperative to align materials development with rationalized synthesis protocols. In this study, we present an innovative technique utilizing atmospheric-pressure chemical vapor deposition (APCVD) to rapidly produce TiO2 in just 5 minutes using pure TiCl4 as the sole reagent. The resulting photoanode exhibits exceptional photoelectrochemical (PEC) water-splitting performance, achieving a photocurrent density of 2.06 mA cm−2 at 1.23 V RHE. Moreover, the photoanode demonstrates sustained operation for 16 hours, leading to the successful collection of 138 μmol of H2 and 62 μmol of O2. These remarkable results are attributed to the controlled formation of an anatase–rutile phase-junction, the presence of well-balanced oxygen vacancies, and the bifrustum nanoparticle–nanoflake structure with a unique light trapping effect and large surface area. Density functional theory calculations confirm that the water-splitting reaction primarily occurs at undercoordinated Ti and O atoms in both anatase and rutile TiO2. Notably, the calculated Gibbs free energy values for the hydrogen evolution reaction (HER) differ significantly between rutile (−0.86 eV) and anatase TiO2 (0.22 eV). In the heterojunction, charge transfer enhances the HER performance through shared electronic density, resulting in a synergistic effect that surpasses the capabilities of individual surfaces and underscores the importance of electronic interactions within the junction.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-10-17
    ชื่อวารสาร
  • Catalysis Science and Technology
185 Improvement of adsorption performance and selectivity of GO-COOH towards MB dye through effective carboxylation approach: Combined experimental and DFT studies Improvement of adsorption performance and selectivity of GO-COOH towards MB dye through effective carboxylation approach: Combined experimental and DFT studies

In this work, the impact of carboxylation of graphene oxide (GO) on the adsorption performance and selective adsorption towards methylene blue (MB) dye was explored by both experimental and density functional theory (DFT) approaches. The GO was first synthesized and then functionalized with ClCH2COOH to produce carboxylated GO (GO-COOH). The COOH content and zeta potential at pH 6 for GO-COOH were 6.644% and − 37.2 eV, and for GO were 3.132% and − 29.1 eV, respectively. Results revealed that the adsorption behavior of MB absorbed on the GO and GO-COOH surfaces was best described by the pseudo-second-order model and Langmuir isotherm. The GO-COOH exhibited a maximum adsorption capacity (qm) of 1731 mg/g and was a more active adsorbent compared to the GO (916 mg/g). According to the DFT calculations, the more stable MB/GO-COOH complex and stronger CH···O interaction between OCOOH and H of -CH3 of MB were mainly responsible for the enhanced qm and greater selective adsorption of GO-COOH, whereas other interactions like S···O, CH···N interactions and other CH···O interactions were almost identical to MB/GO. These results demonstrate that carboxylation could be a fruitful way to boost the adsorption performance of GO-based adsorbents and eliminate the MB dye pollutants.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-09-20
    ชื่อวารสาร
  • Colloids and Surfaces A: Physicochemical and Engineering Aspects
186 Novel biodegradable nanocomposite hydrogels based on biopolymers and various montmorillonite contents as high-strength coating membranes for efficient slow-release fertilizers Novel biodegradable nanocomposite hydrogels based on biopolymers and various montmorillonite contents as high-strength coating membranes for efficient slow-release fertilizers

Slow-release fertilizers (SRF) have emerged as a sustainable remedy to the environmental problems caused by conventional water-soluble fertilizers. They have demonstrated their efficacy in reducing fertilizer dosage applications, enhancing fertilizer utilization efficiency, minimizing losses, and ultimately improving crop yield. This study developed biodegradable nanocomposite hydrogels (BHM) as a promising approach by combining cassava starch (Cst), polyacrylamide (PAM), natural rubber (NR), and various montmorillonite (MMT) contents (0–10 wt%) and fabricating via free-radical polymerization and semi-interpenetrating polymer network technology, crosslinked by glutaraldehyde. Notably, the addition of MMT played a crucial role and significantly improved the tensile strength, biodegradability, and N release efficiency of the BHM hydrogels. BHM3 (3 wt% MMT) demonstrated the highest swelling ratio of 7074% and improved N release efficiency, mechanical strength, and biodegradation rate by 39.1%, 260% and 58%, respectively, compared to BHM0. The FWBHM formulations (urea coated with BHM and wax layers) also exhibited good biosafety. Finally, FWBHM3 yielded acceptable growth rates, a greater yield, and a 4-fold lower price than commercial SRF. These findings provide a promising route for developing new nanocomposite hydrogels based on Cst, NR, and MMT components with high swelling and water-retention, high strengths, and excellent biodegradation with greater slow-release duration and sustained environments.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-07-08
    ชื่อวารสาร
  • Journal of Industrial and Engineering Chemistry
187 Polybutylene Succinate/Calcium Carbonate Based Biocomposite Film Reinforced with Silica Derived from Non-glutinous Rice Husk Polybutylene Succinate/Calcium Carbonate Based Biocomposite Film Reinforced with Silica Derived from Non-glutinous Rice Husk

The main purpose of this work is to use biomass-based silica made of non-glutinous rice husk as a green and novel additive for polybutylene succinate (PBS)/calcium carbonate (CaCO3) composite film. The approach started from combusting the acid-treated biomass at 600 °C for 30 min to obtain Rice Husk Silica (RHS) ash with 11.76 wt% and a purity of 99%. Not only the highly purified RHS could be utilized as an additive to minimize the use of PBS matrix, but the RHS could function as a co-additive along with CaCO3 particles to reinforce the mechanical as well as thermal properties to the composite film. Throughout, different sizes of CaCO3 were carefully studied from 100, 325, or 1250 mesh in size and the content of RHS was varied from 0 to 15 phr to acquire the optimal conditions for these two additives. The effect of physical properties, mechanical properties, thermal properties, and morphology of all the PBS composite films were thoroughly investigated when either one of the additive contents were varied. The optimum additive conditions were found when 20 phr and 1250 mesh sizes of CaCO3 and 10 phr of RHS were used. With this optimization, the strength and thermal properties of the PBS composite film has been increased significantly (8.03 vs. 13.97 N mm⁻² and 491.83 vs. 496.00 °C, respectively). This research did not only introduce two types of environmental and eco-friendly additives but also successfully enhanced the pre-existing mechanical and thermal properties of the PBS composite films. 

จุฑามาส จิตต์เจริญ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-06-30
    ชื่อวารสาร
  • Journal of Polymers and the Environment
188 Multilayer biocomposites of PLA woven fabric and PBS sheets using compression molding process Multilayer biocomposites of PLA woven fabric and PBS sheets using compression molding process

Biocomposite materials play an important role to replace the conventional polymer composites in the issue of serious environmental problems from the end-used products. The relationship between the design and construction of biocomposites structure and their properties is an important factor to the composite application. In this study, the biocomposites of poly(butylene succinate) (PBS) reinforced with poly(lactic acid) (PLA) woven fabric to improve mechanical properties of PBS matrix was fabricated by compression molding process. The plain weave PLA woven fabrics showed higher tensile strength (28.9%) and modulus (21.5%) than the twill 2/2 weave pattern. However, the flexural strength and modulus of composites reinforced with multi-layers PLA woven fabric are higher than the one-layer reinforcement (57% and 31%, respectively). The impact and peel strength of PLA twill 2/2 weave biocomposite are higher than the plain weaving. The mechanical property of matrix reinforced with plain structure was found to increase on the vertical axis while the twill weaving showed the increase on horizontal axis adhesion between the reinforced PLA woven fabric and the PBS matrix.

เสาวลักษณ์ บุญยอด Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-06-30
    ชื่อวารสาร
  • Polymer Composites
189 Adsorption kinetic and thermodynamic studies of the dyeing process of pineapple leaf fibre with berberine dye and modeling of associated interactions Adsorption kinetic and thermodynamic studies of the dyeing process of pineapple leaf fibre with berberine dye and modeling of associated interactions

There are on-going investigations on the utilization of pineapple leaf fibre (PALF) as a cheap, safe, and eco-friendly natural fibre. The present work aimed to improve PALF preparation using ultrasonication, investigate the adsorption kinetic and thermodynamic aspects of PALF dyed with berberine dye, and to assess their associated molecular interactions. It was found that concomitant PALF exposure to NaOH solution (5% w/v) plus ultrasonication for 20 min successfully removed non-cellulosic substances from the fibre surface in a very much shorter time compared with the traditional non-ultrasound assisted method (24 h). An adsorption isotherm study of dyeing, the treated fibre with the natural yellow dye berberine revealed a strong adsorption dependence on the pH of the berberine solution with optimal uptake occurring at pH 9–10. A deeper assessment of the mode of dye binding was undertaken by DFT − based calculations on a model cellulose unit and berberine. It revealed that the interaction between berberine and cellulose (PALF) at pH 9.00 was likely to be substantially stronger than at lower pH. From the adsorption kinetic results, a higher affinity and more dye uptake were observed before equilibrium was reached. The adsorption isotherm data could be represented by the Langmuir isotherm (R2 > 0.99). The enthalpy change (ΔH°) and entropy change (ΔS°) values of dyeing were found to be −17.0 kJ mol−1 and −19.4 J mol−1 K−1 respectively, which pointed to the dye adsorption being an exothermic process. The negative standard affinity (Δµo) values at the different temperatures of 30, 60, and 80 °C were −11.2, −10.6, and −10.2 kJ mol−1, respectively. It affirmed the dye adsorption process as a spontaneous one. Higher temperatures resulted in a lower affinity and reduced dye uptake compatible with the process being exothermic. Berberine is a potentially useful natural dye for PALF without the need for additives.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2023-05-31
    ชื่อวารสาร
  • Arab Journal of Basic and Applied Sciences
190 Enhancing antibacterial activity and air filtration performance in electrospun hybrid air filters of chitosan (CS)/AgNPs/PVA/cellulose acetate: Effect of CS/AgNPs ratio Enhancing antibacterial activity and air filtration performance in electrospun hybrid air filters of chitosan (CS)/AgNPs/PVA/cellulose acetate: Effect of CS/AgNPs ratio

The increase in particulate matter (PM), especially PM2.5, has become a global threat to human health. To get rid of this severe pollutant, air filtration is forecasted as a promising, cost-effective, and effective method. This study utilized dual-spinneret electrospinning to fabricate the electrospun hybrid nanofibrous membranes (EHMs) of chitosan (CS)/silver nanoparticles (AgNPs)/polyvinyl alcohol (PVA)/cellulose acetate (CA). The effect of CS/AgNPs ratios was also investigated to obtain high-efficient air filtration membranes with outstanding antibacterial activity. Results disclosed that EHMs containing high AgNPs content improved the filtration performance and antibacterial properties while decreasing the wettability and tensile strength of EHM membranes. In addition, the EHM1 was found to be the most effective air filter membrane due to its high filtration efficiency of 99.78 % (PM2.5), low-pressure drop of 61.15 Pa, high-quality factor of 0.09 Pa−1, and enhanced inhibition zone of 100–141 %. Thus, this study suggests that the EHMs of CS/AgNPs/PVA/CA with a high AgNPs/CS ratio fabricated via a dual-electrospinning technique are expected to be a promising material choice for an air filter with efficient filtration performance and excellent antibacterial activity, resulting in a more sustainable and healthier future.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-06-19
    ชื่อวารสาร
  • Separation and Purification Technology
191 Paraxylines A-G: Highly oxygenated preurianin-type limonoids with immunomodulatory TLR4 and cytotoxic activities from the stem bark of Dysoxylum parasiticum Paraxylines A-G: Highly oxygenated preurianin-type limonoids with immunomodulatory TLR4 and cytotoxic activities from the stem bark of Dysoxylum parasiticum

Seven previously undescribed preurianin-type limonoids, namely paraxylines A-G, and three known analogs were isolated from stem bark of Dysoxylum parasiticum. The structures, including absolute configurations, were established through spectroscopic analyses, quantum chemical calculations using the density functional theory method, as well as the DP4+ algorithm. Paraxylines A-G were identified as the first preurianin-type with full substitution at C, D-rings, leading to the highly oxygenated seco-limonoids skeleton. The secreted alkaline phosphate assay against an engineered human and murine TLR4 of HEK-Blue cells was performed to evaluate the immune regulating effects. Among them, paraxyline B was found to be a remarkable TLR4 agonist whereas two analogs (toonapubesins A and B) were found to antagonise lipopolysaccharide stimulation of the TLR4 pathway. Paraxylines A and C-E acted either as agonists or antagonists depending on the origin of the TLR4 receptor (human or mouse). The effect of these selected compounds on the expression of pro-inflammatory cytokines TNF-α, IL-1α, IL-1β, and IL-6 of the NF-κB signaling pathway were examined in macrophage cell lines, revealing dose-dependent effects. Additionally, paraxylines A, C, D, and G also presented modest cytotoxic activity against MCF-7 and HeLa cell lines with IC50 values ranging from 23.1 to 43.5 μM.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-04-01
    ชื่อวารสาร
  • Phytochemistry
192 Theoretical insights into CO2 electroreduction on single and dual heteroatom-doped diamonds Theoretical insights into CO2 electroreduction on single and dual heteroatom-doped diamonds

We employed Periodic Density Functional Theory (DFT) to investigate the catalytic activity of single and double dopant of boron (B), nitrogen (N), and phosphorous (P) anchored on diamond surfaces for the CO2 reduction reaction (CO2RR) by analyzing reaction energy profiles. Our findings show that the double-doped catalyst exhibits lower energy barriers in CO2RR compared to the single dopants. Specifically, when considering BB and NN configurations, there is a thermodynamic preference towards the formation of formic acid (HCOOH) with overpotentials of 0.40 and 0.09 V, respectively. The co-doped catalyst comprising B and N (BN) demonstrates a tendency towards the formation of HCOOH without requiring any applied overpotentials. Notably, BN outperforms other catalysts, occupying the top position on the volcano plot, indicating the lowest limiting potential (UL), remarkable thermal stability, and the ability to suppress the competing hydrogen evolution reaction (HER). This research provides valuable insights into the product differentiation in the electroreduction of CO2.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-03-15
    ชื่อวารสาร
  • Fuel
193 Smart dual imprinted Origami 3D-ePAD for selective and simultaneous analysis of vanillylmandelic acid and 5-hydroxyindole-3-acetic acid carcinoid cancer biomarkers using graphene quantum dots coated with dual molecularly imprinted polymers Smart dual imprinted Origami 3D-ePAD for selective and simultaneous analysis of vanillylmandelic acid and 5-hydroxyindole-3-acetic acid carcinoid cancer biomarkers using graphene quantum dots coated with dual molecularly imprinted polymers

Measuring the levels of the biomarkers vanillylmandelic acid (VMA) and 5-Hydroxyindole-3-acetic acid (5-HIAA) is a valuable tool for clinical diagnosis not only of neuroblastoma or carcinoid syndrome, but also of essential hypertension, depression, migraine, and Tourette's syndrome. Herein, we explore using graphene quantum dots (GQDs) coated with molecularly imprinted polymer (MIP) as novel dual-imprinted sensors for selective and simultaneous determination of VMA and 5-HIAA in urine and plasma samples. The dual-MIP was successfully coated on the GQDs core via co-polymerization of (3-aminopropyl) triethoxysilane (APTES) and tetraethyl orthosilicate (TEOS), acting as functional and cross-linking monomers, respectively. In addition, we successfully created the dual imprinted VMA and 5-HIAA shell on the GQDs' core via a one-pot synthesis. We fabricated a facile and ready-to-use Origami three-dimensional electrochemical paper-based analytical device (Origami 3D-ePAD) for simultaneous determination of VMA and 5-HIAA using a GQDs@dual-MIP modified graphene electrode (GQDs@dual-MIP/SPGE). The Origami 3D-ePAD was designed to form a voltammetric cell on a three-layer foldable sheet with several advantages. For example, they were quickly assembled and enhanced the device's physical durability with the hydrophobic backup sheet. The developed dual imprinted Origami 3D-ePAD leads to substantially enhanced sensitivity and selectivity to electrochemical signal amplification generated from increasing the electrode-specific surface area, electrocatalytic activity, and the large numbers of dual imprinted sites for VMA and 5-HIAA detection. The synthetic recognition sites are highly selective for 5-HIAA and VMA molecules with an imprinting factor of 8.46 and 7.10, respectively. Quantitative analysis relying on square wave voltammetry reveals excellent linear dynamic ranges of around 0.001–25 μM, with detection limits of 0.023 nM for 5-HIAA and 0.047 nM for VMA (3Sb, n = 3). The Origami 3D-ePAD provides high accuracy and precision (i.e., recovery values of 5-HIAA ranged from 82.98 to 98.40 %, and VMA ranged from 83.28 to 104.39 %), and RSD less than 4.37 %) in urine and plasma samples without any evidence of interference. Hence, it is well suited as a facile and ready-to-use disposable device for point-of-care testing. It is straightforward, cost-effective, reproducible, and stable. Furthermore, it allows for rapid analysis (analysis time ∼20s) useful in medical diagnosis and other relevant fields.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-03-01
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  • Talanta
194 Innovative environment-friendly liquid fertilizer bead from sodium alginate coating with IPN membrane derived from natural rubber and cassava starch Innovative environment-friendly liquid fertilizer bead from sodium alginate coating with IPN membrane derived from natural rubber and cassava starch

This research aims to prepare liquid fertilizer beads formed with sodium alginate (SA) (SAB) that were coated with interpenetrating polymer network (IPN) hydrogels based on pre-vulcanized natural rubber latex (NR) and cassava starch (St) (IPN NR/St) for controlling the release of the urea solutions. The preparation of SAB at various concentrations of SA and calcium chloride (CaCl2) solutions was investigated. Optimal concentrations were determined to be 1.5% and 5.0 wt% for SA and CaCl2, respectively. Subsequently, the obtained SAB underwent coating with IPN NR/St, utilizing a ratio of 1.0/1.0 between SAB and IPN NR/St, with two layers of coating. The resulting coated alginate beads (CSAB) exhibited the ability to slow down the release of urea solution, contributing to enhanced growth in Thai eggplants. Beyond efficient urea release control, CSAB presents advantages in mitigating environmental issues associated with traditional fertilizers. The study proposes CSAB as an innovative technique for the coating and controlled liquid release of organic or biofertilizers. The potential benefits extend to promoting sustainable agriculture practices while addressing environmental concerns, marking CSAB as a promising solution for organic and biofertilizer applications.

ชัยวุฒิ วัดจัง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-03-01
    ชื่อวารสาร
  • Journal of Polymer Research
195 Synergetic coupling of hydrogen-bond bridge and multielectron redox towards stable and efficient lithium storage Synergetic coupling of hydrogen-bond bridge and multielectron redox towards stable and efficient lithium storage

The flexible molecular engineering has been emerged as a viable option for constructing the high-performance organic cathodes. Herein, a unique crystalline organic supramolecular structure of hexaazatrinaphthalene tricarboxylic acid (denoted as HOS-HATNTA) is engineered by constructing a hydrogen-bonded bridge between the organic ligands, which features to couple the synergetic effects of stable network structure and multiple paths for electron redox. Not only does the bridge serve as a stable channel to allow triggering a chain of similar displacements for transporting ions, but the bridge itself also play an important role in boosting the electron transfer between the pyrazine N in different layers, which enables the efficient lithium storage. As a result, HOS-HATNTA cathode exhibits an all-round elevation of electrochemical metrics including the large specific capacity (271.6 mAh g−1 at 50 mA g−1), large-current tolerance (144.3 mAh g−1 at 5 A g−1), and the impressive long-life span (> 3000 cycles at 3 A g1). Mechanistic studies encompassing XPS, in-situ Raman, kinetic analyses and DFT calculations comprehensively reveals the multiple mechanism of hydrogen bond supramolecule network in electrochemical behaviors for LIBs, which bring a promising insight into engineering high performance organic cathode materials.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-03-01
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  • Energy Storage Materials
196 New acylphloroglucinols from a crude acetone extract of Eucalyptus camaldulensis Dehnh. Leaf New acylphloroglucinols from a crude acetone extract of Eucalyptus camaldulensis Dehnh. Leaf

Acylphloroglucinols are well-known Eucalyptus secondary metabolites which exhibit a variety of structures and bioactivities. The investigation of a crude acetone extract of Eucalyptus camaldulensis leaves led to the isolation of two new acylphloroglucinols, eucalypcamals O and P (1 and 2) together with seven phloroglucinols (3-9), and a benzene derivative (10). Their chemical structures were elucidated by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and mass spectroscopy. The absolute configurations of compounds 1 and 2 were established by comparison of experimental and calculated electronic circular dichroism (ECD) data. In the putative biosynthetic pathway, eucalypcamals O and P should be derived from hetero-Diels-Alder reaction between grandinol and trans-isoeugenol.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-02-01
    ชื่อวารสาร
  • Natural Product Research
197 Preparation of water swellable rubber from epoxidized natural rubber and sodium acrylate by in-situ polymerization: Effect of vulcanization system, epoxide, and dicumyl peroxide, and sodium acrylate content Preparation of water swellable rubber from epoxidized natural rubber and sodium acrylate by in-situ polymerization: Effect of vulcanization system, epoxide, and dicumyl peroxide, and sodium acrylate content

Water swellable rubber (WSR) was prepared from epoxidized natural rubber (ENR) and sodium acrylate (NaAA) by in-situ polymerization using sulfur and dicumyl peroxide (DCP) as a vulcanizing agent and an initiator, respectively. The ENR, NaAA, and other additives were mixed in an internal mixer and a two-roll mill. The effect of the vulcanization system, epoxide, and DCP, and NaAA content on the vulcanization, physical, and mechanical properties of WSR were investigated in this research. As the results, the scorch and curing time of WSR compounded with ENR 25 and vulcanized with a mixture of sulfur-peroxided or mixed vulcanization system were less than other systems. Furthermore, the scorch and curing time decreased with the increase in DCP content. The WSR with ENR 50 vulcanized with DCP (1.5 phr) in the mixing system provided the highest tensile strength. However, the volume change of WSR with the mixing system (WSR/M) was lower than the WSR cured with peroxide (WSR/P). For WSR/P, the tensile strength, hardness, and volume change in water increased with increasing DCP, and NaAA content, while the elongation at break decreased. These results suggest that WSR has the potential for diverse applications, including waterproofing and sealing solutions in civil construction projects.

ชัยวุฒิ วัดจัง Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-02-01
    ชื่อวารสาร
  • Polymer Engineering and Science
198 Anti-Inflammatory Properties of Oxygenated Isocoumarins and Xanthone from Thai Mangrove-Associated Endophytic Fungus Setosphaeria rostrata Anti-Inflammatory Properties of Oxygenated Isocoumarins and Xanthone from Thai Mangrove-Associated Endophytic Fungus Setosphaeria rostrata

Chronic inflammation plays a crucial role in the development and progression of numerous chronic diseases. To search for anti-inflammatory metabolites from endophytic fungi isolated from plants growing in Thai mangrove areas, a chemical investigation of those fungi was performed. Five new oxygenated isocoumarins, setosphamarins A-E (1-5) were isolated from the EtOAc extract of an endophytic fungus Setosphaeria rostrata, along with four known isocoumarins and one xanthone. Their structures were determined by extensive spectroscopic analysis. The absolute configurations of the undescribed compounds were established by comparative analysis between experimental and calculated circular dichroism (ECD) spectroscopy. All the compounds were evaluated for their anti-inflammatory activity by monitoring nitric oxide inhibition in lipopolysaccharide-induced macrophage J774A.1 cells. Only a xanthone, ravenelin (9), showed potent activity, with an IC50 value of 6.27 μM, and detailed mechanistic study showed that it suppressed iNOS and COX-2 expression.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-02-01
    ชื่อวารสาร
  • Molecules
199 Toward the early diagnosis of tuberculosis: A gold particle-decorated graphene-modified paper-based electrochemical biosensor for Hsp16.3 detection Toward the early diagnosis of tuberculosis: A gold particle-decorated graphene-modified paper-based electrochemical biosensor for Hsp16.3 detection

Tuberculosis (TB) currently remains a major life-threatening disease as it can be fatal if not treated properly or in a timely manner. Herein, we first describe a disposable and cost-effective paper-based electrochemical biosensor based on a gold particle-decorated carboxyl graphene (AuPs/GCOOH)-modified electrode for detecting heat shock protein (Hsp16.3), which is a specific biomarker indicating the onset of TB infection. The device pattern was first engineered to facilitate detection procedures and printed on low-cost filter paper to create hydrophobic and hydrophilic regions using a wax printing technique. Immunoassays proceeded in a half-sandwich format because it is a reagent-less approach and requires no labeling step. The fabrication of the immunosensor began with GCOOH drop casting, the electrochemical deposition of AuPs, and the establishment of a biorecognition layer against Hsp16.3 utilizing 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS)-sulfo standard chemistry. The appearance of Hsp16.3 resulted in a substantial decrease in the electrochemical signal response of the redox probe employed [Fe (CN)6]3−/4− due to the created immunocomplexes that possess insulation properties. GCOOH enables direct antibody immobilization, and AuPs enhance the electrochemical properties of the sensor. This proposed immunosensor, while requiring only a miniscule sample volume (5 μL), achieved superior performance in terms of the limit of detection, measuring at 0.01 ng/mL. Our platform was confirmed to be highly specific to Hsp16.3 and can rapidly detect TB-infected sera without necessitating any pre-enrichment (20 min), making it an alternative and particularly suitable for the early diagnosis of TB in resource-scarce countries.

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-01-15
    ชื่อวารสาร
  • Talanta
200 Eco-friendly thermosensitive magnetic-molecularly-imprinted polymer adsorbent in dispersive solid-phase microextraction for gas chromatographic determination of organophosphorus pesticides in fruit samples Eco-friendly thermosensitive magnetic-molecularly-imprinted polymer adsorbent in dispersive solid-phase microextraction for gas chromatographic determination of organophosphorus pesticides in fruit samples

A thermosensitive magnetic-molecularly-imprinted polymer (TMMIP) was successfully prepared in an aqueous medium. The TMMIP was applied as an effective adsorbent in dispersive solid-phase microextraction for the selective enrichment of five organophosphorus pesticides (OPPs; diazinon, fenitrothion, fenthion, parathion-ethyl, and ethion) before analysis by gas chromatography. The polymerization was performed using mixed-valence iron hydroxide nanoparticles as the magnetic support, N-isopropyl acrylamide as the thermosensitive monomer, ethion as the template, and methacrylic acid as the functional monomer. The adsorption and desorption mechanisms of OPPs depend on their interactions with the adsorbents and solution temperature. Our methodology provides good linearity (0.50–2000 µg L-1), with a correlation determination of R2 > 0.9980, low limit of detection (0.25–0.50 µg L-1), low limit of quantitation (0.50–1.50 μg L−1), and high precision (%RSD < 7%). The developed method demonstrates excellent applicability for accurately and efficiently determining OPP residuals in fruit and vegetable samples with good recoveries (93–117%).

เกษริน สีบุญเรือง Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-01-01
    ชื่อวารสาร
  • Food Chemistry
201 Computational and experimental investigations of a novel aptamer targeting oxidized low-density lipoprotein Computational and experimental investigations of a novel aptamer targeting oxidized low-density lipoprotein

Oxidized low-density lipoprotein (oxLDL) induces the formation of atherosclerotic plaques. Apolipoprotein B100 (apoB100) is a crucial protein component in low-density lipoprotein (LDL), which includes oxLDL. The oxidation of amino acids and subsequent alterations in their structure generate oxLDL, which is a significant biomarker for the initial phases of coronary artery disease. This study employed molecular docking and molecular dynamics utilizing the MM/GBSA method to identify aptamers with a strong affinity for oxidized apoB100. Molecular docking and molecular dynamics were performed on two sequences of the aptamer candidates (aptamer no.11 (AP11: 5′-CTTCGATGTAGTTTTTGTATGGGGTGCCCTGGTTCCTGCA-3′) and aptamer no.26 (AP26: 5′-GCGAACTCGCGAATCCAGAACGGGCTCGGTCCCGGGTCGA-3′)), yielding respective binding free energies of −149.08 kcal/mol and −139.86 kcal/mol. Interaction modeling of the simulation revealed a strong hydrogen bond between the AP11-oxidized apoB100 complexes. In an aptamer-based gold nanoparticle (AuNP) aggregation assay, AP11 exhibits a color shift from red to purple with the highest absorbance ratio, and shows strong binding affinity to oxLDL, correlating with the simulation model results. AP11 demonstrated the potential for application as a novel recognition element in diagnostic methodologies and may also contribute to future advancements in preventive therapies for coronary artery disease.

มะลิวรรณ อมตธงไชย Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-09-01
    ชื่อวารสาร
  • Computers in Biology and Medicine
202 A sensitive paper-based vapor-test kit for instant formalin detection in food products A sensitive paper-based vapor-test kit for instant formalin detection in food products

A colorimetric sensing method based on a paper-based vapor-test kit was successfully developed for the selective and sensitive real-time monitoring of formalin in food samples. The device was specifically designed to efficiently extract and detect formalin simultaneously. A microcentrifuge tube was used as the sample solution container, with the inner cap serving as the reaction and detection zone. Formalin was converted into gaseous formaldehyde through controlled heating, which was then extracted and collected on a filter paper coated with Nash’s reagent. The color change on paper was used for formalin quantification using a smartphone for detection and image analysis. Under optimal conditions, our method provided a linear range of 0.5–75 mg L− 1 with a detection limit of 0.11 mg L− 1 . This method effectively determined formalin in fresh food and vegetable samples, with recoveries ranging from 92 to 111%, demonstrating comparable accuracy to the standard method for practical food quality control and safety. 

เกษริน สีบุญเรือง Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-09-01
    ชื่อวารสาร
  • Food Chemistry
203 Synthesis and Structure-Property Relationship of meso-Substituted Porphyrin- and Benzoporphyrin-Thiophene Conjugates toward Electrochemical Reduction of Carbon Dioxide Synthesis and Structure-Property Relationship of meso-Substituted Porphyrin- and Benzoporphyrin-Thiophene Conjugates toward Electrochemical Reduction of Carbon Dioxide

A novel series of ZnII-trans-A2B2 porphyrins and benzoporphyrins bearing phenyl and thiophene-based meso-substituents was successfully synthesized and characterized by spectroscopic and electrochemical techniques. Systematic comparison among the compounds in this series, together with the corresponding A4 analogs previously studied by our group, led to the understanding of the effects of π-conjugated system extension of a porphyrin core through β-fused rings, replacement of the phenyl with the thiophene-based meso-groups, and introduction of additional thiophene rings on thienyl substituents on photophysical and electrochemical properties. Oxidative electropolymerization through bithiophenyl units of both A4 and trans-A2B2 analogs was achieved, resulting in porphyrin– and benzoporphyrin–oligothiophene conjugated polymers, which were characterized by cyclic voltammetry and absorption spectrophotometry. Preliminary studies on catalytic performance toward electrochemical reduction of carbon dioxide (CO2) was described herein to demonstrate the potential of the selected compounds for serving as homogeneous and heterogeneous electrocatalysts for the conversion of CO2 to carbon monoxide (CO).

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-08-26
    ชื่อวารสาร
  • Energy and Fuels
204 Ligand-Based Virtual Screening for Discovery of Indole Derivatives as Potent DNA Gyrase ATPase Inhibitors Active against Mycobacterium tuberculosis and Hit Validation by Biological Assays Ligand-Based Virtual Screening for Discovery of Indole Derivatives as Potent DNA Gyrase ATPase Inhibitors Active against Mycobacterium tuberculosis and Hit Validation by Biological Assays

Mycobacterium tuberculosis is the single most important global infectious disease killer and a World Health Organization critical priority pathogen for development of new antimicrobials. M. tuberculosis DNA gyrase is a validated target for anti-TB agents, but those in current use target DNA breakage-reunion, rather than the ATPase activity of the GyrB subunit. Here, virtual screening, subsequently validated by whole-cell and enzyme inhibition assays, was applied to identify candidate compounds that inhibit M. tuberculosis GyrB ATPase activity from the Specs compound library. This approach yielded six compounds: four carbazole derivatives (1, 2, 3, and 8), the benzoindole derivative 11, and the indole derivative 14. Carbazole derivatives can be considered a new scaffold for M. tuberculosis DNA gyrase ATPase inhibitors. IC50 values of compounds 8, 11, and 14 (0.26, 0.56, and 0.08 μM, respectively) for inhibition of M. tuberculosis DNA gyrase ATPase activity are 5-fold, 2-fold, and 16-fold better than the known DNA gyrase ATPase inhibitor novobiocin. MIC values of these compounds against growth of M. tuberculosis H37Ra are 25.0, 3.1, and 6.2 μg/mL, respectively, superior to novobiocin (MIC > 100.0 μg/mL). Molecular dynamics simulations of models of docked GyrB:inhibitor complexes suggest that hydrogen bond interactions with GyrB Asp79 are crucial for high-affinity binding of compounds 8, 11, and 14 to M. tuberculosis GyrB for inhibition of ATPase activity. These data demonstrate that virtual screening can identify known and new scaffolds that inhibit both M. tuberculosis DNA gyrase ATPase activity in vitro and growth of M. tuberculosis bacteria.

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-08-12
    ชื่อวารสาร
  • Journal of Chemical Information and Modeling
205 Optimizing modified natural rubber in starch-based hydrogels: A cost-effective approach for high-performance sustainable slow-release fertilizer coatings Optimizing modified natural rubber in starch-based hydrogels: A cost-effective approach for high-performance sustainable slow-release fertilizer coatings

Effective compatibility between natural rubber (NR) and cassava starch (CSt) is crucial for enhancing the water swelling and retention properties of CSt/NR-based hydrogels. In this study, NR was modified by grafting glycidyl methacrylate (NR-g-GMA, NRG) at 3, 6, and 9 parts per hundred rubber (phr) for blending with CSt. Subsequently, CSt was grafted with acrylamide (AM), crosslinked with N,N′ − methylene-bis-acrylamide (MBA), and interpenetrated with NRG to produce CSt-g-PAM/NRG hydrogels. The resulting CSt-g-PAM/NRGx (x = phr of GMA) hydrogels were characterized using FTIR, XRD, TGA, tensile testing, and water swelling measurements. Results revealed that CSt-g-PAM/NRG3 exhibited the highest equilibrium water swelling at 3300 %, surpassing CSt-g-PAM/NR (1430 %) and demonstrated the highest mechanical strength (0.92 MPa), desirable biodegradability (69 % at 30 days), and good water retention. These properties are attributed to the superior compatibility and stronger interactions between NRG and the CSt-g-PAM networks. Additionally, the WUHNRG3 (urea coated with CSt-g-PAM/NRG3 and wax layers) fertilizer demonstrated good biosafety, an acceptable slow-release rate (50.26 % at 30 days), and effectively promoted the growth of chili plants at a reasonable cost. This study demonstrates that modifying NR with optimal GMA content provides an effective CSt-g-PAM/NRG coating membrane, suitable for sustainable slow-release fertilizers and green agricultural practices.

สายันต์ แสงสุวรรณ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-08-05
    ชื่อวารสาร
  • Journal of Industrial and Engineering Chemistry
206 Alliaceumolide A: A rare undescribed 17-membered macrolide from Indonesian Dysoxylum alliaceum Alliaceumolide A: A rare undescribed 17-membered macrolide from Indonesian Dysoxylum alliaceum

Alliaceumolide A (1), a new macrolide together with known ivorenolide B (2) were isolated from Dysoxylum alliaceum (Blume) Blume ex A.Juss. These compounds were classified as 17-membered macrolide, which is a rare structure for plant-derived natural products. The structures were elucidated by extensive spectroscopic analyses, and the absolute configuration of 1 was determined by electronic circular dichroism (ECD) using TDDFT method. Furthermore, compounds 1 and 2 were tested for cytotoxic activity against two cancer MCF-7 and HeLa cell lines.

ศิริพร จึงสุทธิวงษ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-08-01
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  • Phytochemistry Letters
207 Advancing CO2 hydrogenation to formic Acid: DFT insights into Frustrated Lewis Pair−Functionalized UiO−67 catalysts Advancing CO2 hydrogenation to formic Acid: DFT insights into Frustrated Lewis Pair−Functionalized UiO−67 catalysts

In this study, we explore the potential of metal–organic frameworks (MOFs) as catalysts for converting CO2 into valuable chemicals. The focus is on integrating frustrated Lewis pairs (FLPs) within the UiO-67 framework. We investigated eight distinct functionalized FLP moieties (X = −F, −Cl, −Br, −H, −CH3, −CF3, −CN, and −NO2) to determine their ability to activate small molecules within homogeneous catalysis using density functional theory. This study reveals two critical stages in the CO2 conversion process with H2 in UiO−67−X. First, the initial heterolytic cleavage of H2 at the FLP site, and second, the subsequent hydrogenation of CO2. The latter involves the addition of a hydride and a proton. Our findings demonstrate that these modifications facilitate efficient dissociation of H2 into Hδ− and Hδ+ with energy barriers ranging from barrierless to 0.67 eV and CO2 hydrogenation barriers spanning from 0.70 to 2.03 eV. Notably, the −B(CH3)2 functional group exhibited superior effectiveness in CO2 hydrogenation to formic acid (HCOOH; FA). This group outperformed others, especially under the lowest operational conditions of 400 K and 1 bar pressure. This enhanced activity correlates directly with FLP acidity and the energy changes in H2 dissociation. It highlights the significant influence of FLP−assisted heterolytic dissociation of H2 in the CO2 conversion process. The results of this study do more than introduce metal-free heterogeneous FLPs within MOFs. They also establish a clear link between the functional group composition, FLP acidity, and catalytic efficiency. These insights offer a valuable theoretical foundation for the design of advanced UiO−67−X catalysts. They open up possibilities for transforming greenhouse gases into valuable chemical products, contributing to sustainable chemical synthesis.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-08-01
    ชื่อวารสาร
  • Journal of Catalysis
208 Ionic Pumping Effect at the Tailored Mesoporous Carbon Interface for an Extra-Stable Lithium Ion Battery at Low Temperatures Ionic Pumping Effect at the Tailored Mesoporous Carbon Interface for an Extra-Stable Lithium Ion Battery at Low Temperatures

Ion transportation at the interface significantly influences the electrochemical performance of the lithium ion battery, especially at high rates and low temperatures. Here, we develop a controlled self-assembly strategy for constructing a mesoporous carbon nanolayer with a uniform pore size and varied thicknesses on the two-dimensional monolayer MXene substrate. On the basis of the excellent electron conductivity of MXene, the mesoporous carbon layer is found with a voltage-driven ion accumulation effect, acting as an “ionic pump”. The thicker mesoporous layer (∼2.28 nm) has the ability to accommodate a substantial quantity of ions, demonstrating enhanced ionic conductivity, remarkable cycling stability (192.8 mAh/g after 9400 cycles at 5.0 A/g), and outstanding rate capability at ambient and sub-zero temperatures (∼601 mAh/g at 0 °C and 0.05 A/g). This work provides valuable insights and guidance for the further development of high-performance electrode materials at high rates or low temperatures.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-07-24
    ชื่อวารสาร
  • Nano Letters
209 Quantifying non-transferrin-bound iron (NTBI) in human plasma: incorporating BODIPY-pyridylhydrazone (BODIPY-PH) within a thin green film linked to a portable fluorescence-based device Quantifying non-transferrin-bound iron (NTBI) in human plasma: incorporating BODIPY-pyridylhydrazone (BODIPY-PH) within a thin green film linked to a portable fluorescence-based device

Free iron in human serum or non-transferrin-bound iron (NTBI) can generate free radicals and lead to oxidative damage. Moreover, it is highly toxic to various tissues and a vital biomarker related to the iron-loading status of thalassemia and Alzheimer’s patients. In NTBI in healthy individuals, NTBI levels are typically less than 1 µM; current NTBI analysis usually requires advanced instrumentation and many-step sample pretreatment. To address this issue, we employed our invented BODIPY derivative, BODIPY-PH, as a fluorescence probe and trapped it onto the microcentrifuge tube lid using tapioca starch. The fluorescence intensity of BODIPY-PH increased with increasing NTBI concentration (turn-on). The developed portable reaction chamber facilitates rapid analysis (∼5 min) using small sample volumes (10 μL sample in a total volume of 600 μL). Under optimum conditions, using the sample-developed portable fluorescence device and fluorescence spectrometer, we achieved impressive limits of detection (LOD) of 0.003 and 0.0015 μM, respectively. Furthermore, the developed sensors show relatively high selectivity toward Fe3+ over other metal ions and biomolecules (i.e., Fe2+, Cr3+, Cu2+, and glucose). The sensor performance in serum samples of thalassemia patients exhibited no significant difference compared to the labeled value (obtained from standard methods). Overall, the developed fluorescence sensor is suitable for determining NTBI and offers high sensitivity, high selectivity, and a short incubation time (5 min). Moreover, the method requires a limited number of reagents, is simple to use, and uses low-cost equipment to determine NTBI in human serum samples. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer-Verlag GmbH, DE part of Springer Nature 2024.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-07-19
    ชื่อวารสาร
  • Analytical and Bioanalytical Chemistry
210 Point-of-care blood tests using a smartphone-based colorimetric analyzer for health check-up Point-of-care blood tests using a smartphone-based colorimetric analyzer for health check-up

A microscale colorimetric assay was designed and implemented for the simultaneous determination of clinical chemistry tests measuring six parameters, including glucose (GLU), total protein (TP), human serum albumin (HSA), uric acid (UA), total cholesterol (TC), and triglycerides (TGs) in plasma samples. The test kit was fabricated using chromogenic reagents, comprising specific enzymes and binding dyes. Multiple colors that appeared on the reaction well when it was exposed to each analyte were captured by a smartphone and processed by the homemade Check6 application, which was designed as a colorimetric analyzer and simultaneously generated a report that assessed test results against gender-dependent reference ranges. Six blood checkup parameters for four plasma samples were conducted within 12 min on one capture picture. The assay achieved wide working concentration ranges of 10.45–600 mg dL−1 GLU, 1.39–10.0 g dL−1 TP, 1.85–8.0 g dL−1 HSA, 0.86–40.0 mg dL−1 UA, 11.28–600 mg dL−1 TC, and 11.93–400 mg dL−1 TGs. The smartphone-based assay was accurate with recoveries of 93–108% GLU, 93–107% TP, 92–107% HSA, 93–107% UA, 92–107% TC, and 99–113% TGs. The coefficient of variation for intra-assay and inter-assay precision ranged from 3.2–5.2% GLU, 4.6–5.3% TP, 4.3–5.3% HSA, 2.8–6.6% UA, 2.7–6.5% TC, and 1.1–3.9% TGs. This assay demonstrated remarkable accuracy in quantifying the concentration-dependent color intensity of the plasma, even in the presence of other suspected interferences commonly present in serum. The results of the proposed method correlated well with results determined by the microplate spectrophotometer (R2 > 0.95). Measurement of these six clinical chemistry parameters in plasma using a microscale colorimetric test kit coupled with the Check6 smartphone application showed potential for real-time point-of-care analysis, providing cost-effective and rapid assays for health checkup testing.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-07-01
    ชื่อวารสาร
  • Microchimica Acta
211 Characteristics and catalytic properties of WO3 supported on zeolite A-derived from fly ash of sugarcane bagasse via esterification of ethanol and lactic acid Characteristics and catalytic properties of WO3 supported on zeolite A-derived from fly ash of sugarcane bagasse via esterification of ethanol and lactic acid

In the current trend of industrial manufacturing processes, an interest in utilization of industrial and agricultural wastes for producing green chemistry, eco-friendly product, has been increased. Therefore, this study aimed to produce ethyl lactate using solid-acid catalyst WO3/zeolite-A via esterification. Various analytical techniques, including XRF, BET, XPS, FTIR, NH3-IR, NH3-TPD, SEM-EDX, ICP-OES, XRD, TGA-DTA, and TEM, were employed to analyze the physical and chemical properties of zeolite-A and tungsten-supported on zeolite-A. The results revealed that after five reuse cycles, the lactic acid conversion rates were 20.1 % and 10.3 % for WO3/zeolite-A and Amberlyst-15, respectively. The spent WO3/zeolite-A exhibited a reduction in surface acid site, declining from 1,591.8 μmol/g in the first run to 690.1 μmol/g in the fifth run. The decline in efficiency was attributed to impurities blocking of active sites, structural alterations, and partial leaching of active species. XRD and FTIR analyses confirmed decreased crystallinity and structural changes in spent catalysts. TEM, SEM-EDS, and ICP-OES analyses showed the loss of active tungsten species and the deposition of reaction intermediates leading to a decrease in ethyl lactate yield (decreased from ca. 44 to 20 %). Despite structural changes affecting catalytic performance, WO3/zeolite-A demonstrated a good promising catalyst for ethyl lactate production over five successive cycles (with ca. 50 % decrease).

พรพรรณ พึ่งโพธิ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-07-01
    ชื่อวารสาร
  • South African Journal of Chemical Engineering
212 Peroxidase-like Activity of Aptamer-Gold Nanoparticles for Selective and Sensitive Fluorescence Detection of Low-Density Lipoproteins Peroxidase-like Activity of Aptamer-Gold Nanoparticles for Selective and Sensitive Fluorescence Detection of Low-Density Lipoproteins

Low-density lipoprotein cholesterol (LDL-C), commonly called “bad cholesterol”, is crucial to cardiovascular health. Increased LDL-C levels pose a substantial risk to human health. As a result, there is a demand for reliable, affordable, and highly sensitive analytical methods for LDL-C detection. Herein, a facile fluorometric aptasensor for LDL-C detection based on the aptamer-enhanced peroxidase-mimicking activity of gold nanoparticles (AuNPs) has been developed. AuNPs were functionalized with LDL-C-specific thiolated aptamer to enhance their intrinsic peroxidase-like activity, which could effectively catalyze the oxidation of o-phenylenediamine dihydrochloride (OPD) by H2O2 into the yellow-fluorescent product 2,3-diamino phenazine (DAP). The characterization studies confirmed that the presence of the aptamer enhances the affinity of AuNPs toward the OPD substrate, thereby leading to a marked increase in the peroxidase-mimicking activity. Moreover, after being functionalized with an aptamer, increased dispersibility and substrate affinity of AuNPs were achieved. Using LDL-C as a target analyte, under optimum conditions, a linear relationship between smartphone-recorded signal intensity and the logarithm of the analyte concentration was observed in the range of 0.05–1 mg dL–1 and the limit of detection was 0.0230 mg dL–1. The results agree with those obtained by a clinical laboratory method. This proposed method is readily deployable and a promising prototype for diverse diagnostic applications, particularly in biomarker detection within serum or plasma samples. It holds the potential to yield substantial advantages in point-of-care testing.

ปุริม จารุจำรัส Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-06-14
    ชื่อวารสาร
  • ACS Applied Nano Materials
213 Signal Propagation in the ATPase Domain of Mycobacterium tuberculosis DNA Gyrase from Dynamical-Nonequilibrium Molecular Dynamics Simulations Signal Propagation in the ATPase Domain of Mycobacterium tuberculosis DNA Gyrase from Dynamical-Nonequilibrium Molecular Dynamics Simulations

DNA gyrases catalyze negative supercoiling of DNA, are essential for bacterial DNA replication, transcription, and recombination, and are important antibacterial targets in multiple pathogens, including Mycobacterium tuberculosis, which in 2021 caused >1.5 million deaths worldwide. DNA gyrase is a tetrameric (A2B2) protein formed from two subunit types: gyrase A (GyrA) carries the breakage-reunion active site, whereas gyrase B (GyrB) catalyzes ATP hydrolysis required for energy transduction and DNA translocation. The GyrB ATPase domains dimerize in the presence of ATP to trap the translocated DNA (T-DNA) segment as a first step in strand passage, for which hydrolysis of one of the two ATPs and release of the resulting inorganic phosphate is rate-limiting. Here, dynamical-nonequilibrium molecular dynamics (D-NEMD) simulations of the dimeric 43 kDa N-terminal fragment of M. tuberculosis GyrB show how events at the ATPase site (dissociation/hydrolysis of bound nucleotides) are propagated through communication pathways to other functionally important regions of the GyrB ATPase domain. Specifically, our simulations identify two distinct pathways that respectively connect the GyrB ATPase site to the corynebacteria-specific C-loop, thought to interact with GyrA prior to DNA capture, and to the C-terminus of the GyrB transduction domain, which in turn contacts the C-terminal GyrB topoisomerase-primase (TOPRIM) domain responsible for interactions with GyrA and the centrally bound G-segment DNA. The connection between the ATPase site and the C-loop of dimeric GyrB is consistent with the unusual properties of M. tuberculosis DNA gyrase relative to those from other bacterial species.

พรพรรณ พึ่งโพธิ์ Q3 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-06-04
    ชื่อวารสาร
  • Biochemistry
214 Conjugation in polysiloxane copolymers via unexpected Si-O-Si dπ-pπ overlap, a second mechanism? Conjugation in polysiloxane copolymers via unexpected Si-O-Si dπ-pπ overlap, a second mechanism?

We previously reported that functionalized phenyl- and vinyl-silsesquioxanes (SQs) and [RSiO1.5]8,10,12 (R = Ph or vinyl) exhibited redshifted absorption and emission, suggesting 3-D conjugation via a cage-centered lowest unoccupied molecular orbital (LUMO). The functionalized [PhSiO1.5]7(OSiMe3)3 with a missing corner and edge-opened, end-capped [PhSiO1.5]8(OSiMe2)2 (double decker, DD) analogs also exhibit emission redshifts, indicating 3-D conjugation. DD [PhSiO1.5]8(OSiMevinyl)2 and R-Ar-Br copolymers exhibit polymerization (DP)-dependent emission λmax and integer charge transfer (ICT) to 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TNCQ). The terpolymer-averaged redshifts all suggest conjugation with two (O-Si-O) endcaps, possibly via a cage-centered LUMO. In assessing conjugation limits, it was anticipated that copolymers of the ladder (LL) SQ, (vinylMeSiO2)[PhSiO1.5]4(O2SiMevinyl), with Br-Ar-Br and without a cage would eliminate LUMO formation and a redshift. The λmax values observed were greater for analogous copolymers, which requires a different explanation. Here, we assess the photophysical behavior of copolymers closer to polysiloxanes, namely, the expanded cage (MeVinylSiO)2[PhSiO1.5]8(OSiMeVinyl)2SQs. Copolymers with Br-Ar-Br exhibit redshifted absorption and emission, which supports conjugation via Si-O-Si bonds rather than cage-centered LUMOs, contrary to traditional views of Si-O-Si copolymers. One- and two-photon photophysical probes showed that XDD copolymers exhibit multiple fluorescence-emitting excited states, in violation of Kasha’s rule stating that emission should occur only from the lowest excited state. Finally, new modeling studies suggested that conjugation derives from Si-O-Si bond dπ-pπ interactions, an unexpected result for polysiloxanes that supports two forms of conjugation.

ศิริพร จึงสุทธิวงษ์ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-06-01
    ชื่อวารสาร
  • Polymer Journal
215 0 0

A total of five new mexicanolides (15), namely alliaxylines A–E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI–MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC50 values of 34.95 ± 0.21 and 44.39 ± 1.03 µM.

ศิริพร จึงสุทธิวงษ์ Q1 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-06-01
    ชื่อวารสาร
  • Journal of Natural Medicines
216 Preparation and characterization of hydrogels based on glycidyl methacrylate (GMA)-grafted NR and modified cassava starch as eco-friendly materials for sustainable agriculture Preparation and characterization of hydrogels based on glycidyl methacrylate (GMA)-grafted NR and modified cassava starch as eco-friendly materials for sustainable agriculture

Eco-friendly hydrogel was developed using natural rubber latex (NR) and cassava starch (CSt) through grafting modifications to enhance their swelling and water retention by selecting suitable grafting components and improving compatibility. To improve its hydrophilicity and compatibility with CSt, NR was grafted with glycidyl methacrylate (NR-g-GMA, NRG). Subsequently, CSt was grafted with acrylic acid (AA) and acrylamide (AM), crosslinked with N,N′-methylene-bis-acrylamide (MBA), and ultimately interpenetrated by NRG to produce CSt-g-PAA/NRG and CSt-g-PAM/NRG hydrogels, respectively. The obtained hydrogels were characterized by various techniques. Results revealed that CSt-g-PAM/NRG exhibited exceptional equilibrium water swelling (Seq) at 2413%, surpassing CSt-g-PAA/NRG (416%), and CSt/NR (146%). This was attributed to the synergistic effects of the improved NR polarity and compatibility, the looser structures, the higher rate constant of water swelling (20.06%/s), and the greater compatibility between compositions compared to the CSt-g-PAA/NRG system. Therefore, AM was the suitable grafting monomer for the CSt/NRG hydrogel system. Also, the CSt-g-PAM/NRG hydrogel exhibited remarkable water retention for up to 30 days with excellent biodegradation (55%) and good biosafety. This study demonstrates a promising strategy for improving swelling capacity (~1600%) and water retention (58%) of biodegradable CSt/NR hydrogels as a low-cost coating membrane for sustainable agriculture.

สายันต์ แสงสุวรรณ Q2 นานาชาติ
    วันที่ตีพิมพ์
  • 2024-06-01
    ชื่อวารสาร
  • Polymer Engineering and Science
217 Conjugation through Si-O-Si bonds, silsesquioxane (SQ) half cage copolymers, extended examples via SiO0.5/SiO1.5 units: multiple emissive states in violation of Kasha's rule Conjugation through Si-O-Si bonds, silsesquioxane (SQ) half cage copolymers, extended examples via SiO0.5/SiO1.5 units: multiple emissive states in violation of Kasha's rule

We previously reported that phenyl- and vinyl-silsesquioxanes (SQs), [RSiO1.5]8,10,12 (R = Ph or vinyl) functionalized with three or more conjugated moieties show red-shifted absorption- and emission features suggesting 3-D conjugation via a cage centered LUMOs. Corner missing [PhSiO1.5]7(OSiMe3)3 and edge opened, end capped [PhSiO1.5]8(OSiMe2)2 (double decker, DD) analogs also offer red shifted spectra again indicating 3-D conjugation and a cage centered LUMO. Copolymerization of DD [PhSiO1.5]8(OSiMevinyl)2 with multiple R–Ar–Br gives copolymers with emission red-shifts that change with degree of polymerization (DP), exhibit charge transfer to F4TNCQ and terpolymer averaged red-shifts suggesting through chain conjugation even with two (O–Si–O) end caps possibly via a cage centered LUMO. Surprisingly, ladder (LL) SQ, (vinylMeSiO2)[PhSiO1.5]4(O2SiMevinyl) copolymers offer emission red-shifts even greater for analogous copolymers requiring a different explanation. Here we assess the photophysical behavior of copolymers of a more extreme SQ form: the half cage [PhSiO1.5]4(OSiMe2Vinyl)4, Vy4HC SQs. We again see small red-shifted absorptions coupled with significant red-shifted emissions, even with just a half cage, thus further supporting the existence of pπ–dπ and/or σ*–π* conjugation through Si–O–Si bonds and contrary to most traditional views of Si–O–Si linked polymers. These same copolymers donate an electron to F4TCNQ generating the radical anion, F4TCNQ−. as further proof of conjugation. Column chromatographic separation of short from longer chain oligomers reveals a direct correlation between DP and emission λmax red-shifts as another indication of conjugation. Further, one- and two-photon absorption and emission spectroscopy reveals multiple excited fluorescence-emitting states in a violation of Kasha's rule wherein emission occurs only from the lowest excited state. Traditional modeling studies again find HOMO LUMO energy levels residing only on the aromatic co-monomers rather than through Si–O–Si bonds as recently found in related polymers.

 
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