| 1 |
Development of Conceptual Understanding of Oxidation-Reduction Reaction and Determination of Iron Ions Using Smartphone-Assisted Colorimetric Experiment |
Development of Conceptual Understanding of Oxidation-Reduction Reaction and Determination of Iron Ions Using Smartphone-Assisted Colorimetric Experiment |
The main purpose of this study was to develop students’ conceptual understanding of oxidation-reduction reaction and determination of iron ions in water samples. The participants were 36 eleventh grade students. The treatment tool was the experimental determination of iron ions using smartphone-assisted colorimetric analysis. The data collecting tool was a conceptual test consisting of 8 two-tier diagnostic questions. The paired samples T-test analysis indicated that the post-test score (mean 6.83, SD 0.97, % 85.42) was significantly higher than the pre-test score (mean 3.47, SD 1.23, % 43.40) at the significant level of 0.05. The normalized learning gain was 0.74, high gain. After the intervention, the percentages of students in the good understanding (GU), mis-understanding (MU) and no understanding (NU) categories were respectively 70.49, 18.06 and 4.51, while the percentage of students in the non-response (NR) was 6.94. This indicated that the smartphone-assisted colorimetric analysis experiment which was portable, rapid analysis, and no other high-cost instrument required can enhance students’ conceptual understanding of these topics effectively. |
ศักดิ์ศรี สุภาษร |
Oral |
นานาชาติ |
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| 2 |
Development of Conceptual Understanding of Acid-Base Titration Using Paper-Based Experiment for Grade-11 Students |
Development of Conceptual Understanding of Acid-Base Titration Using Paper-Based Experiment for Grade-11 Students |
The main aim of this study was developed students’ conceptual understanding of acidbase titration using paper-based experiment for high school chemistry. Thirty-six grade-11 students were the participants in this study. The treatment tool was the acid-base titration using paper-based experiment. The data collecting tool was a conceptual test of acid-base titration, consisting of 10 two-tier diagnostic items. The paired samples T-test analysis indicated that the post-test score (mean 7.89, SD 1.45, % 78.89) was significantly higher than the pre-test score (mean 3.89, SD 1.43, % 38.89) at the significant level of 0.05. The normalized learning gain was 0.65, medium gain. After the intervention, the percentages of students in the good understanding (GU), mis-understanding (MU), no understanding (NU) and non-response (NR) categories were 68.06, 13.06, 7.50, and 11.39, respectively. This indicated that this paper-based titration experiment which was low-cost, small-scale, and rapid fabrication can enhance students’ conceptual understanding of this topic effectively. |
ศักดิ์ศรี สุภาษร |
Oral |
นานาชาติ |
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| 3 |
The investigation of crucial interactions and binding free energy of novel pyrrolyl benzohydrazide and pyrrolyl benzamide derivatives as InhA inhibitors for anti-tuberculosis agents based on molecular dynamics
simulations |
The investigation of crucial interactions and binding free energy of novel pyrrolyl benzohydrazide and pyrrolyl benzamide derivatives as InhA inhibitors for anti-tuberculosis agents based on molecular dynamics
simulations |
Tuberculosis (TB) is one of the top 10 causes of death worldwide. Enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis is an enzyme which is important for the growth of bacteria. Pyrrolyl benzohydrazide and pyrrolyl benzamide derivatives have been developed as novel InhA inhibitors with promising in vitro InhA inhibitory activity and antimycobacterial activity against Mycobacterium tuberculosis. In this study, the crucial interactions and binding free energy of pyrrolyl benzohydrazide and pyrrolyl benzamide derivatives complexed with InhA were investigated using molecular dynamic simulations and MM-GBSA method. The results showed that binding free energy calculations based on MM-GBSA method was good correlation with the experimental result. Compound 1, the highest active compound, formed Hbonding interaction between H atom of the secondary amine (NH) with O atom of Gly96 that fitted well within the binding pocket of InhA. In addition, compound 25 located in the binding pocket with the hydrophobic interactions mainly with Met155 Tyr158 Met199 Ile202 Leu207. The obtained results can provide fruitfulinformation for further design of new and highly potent InhA inhibitors as anti-tuberculosis agents. |
พรพรรณ พึ่งโพธิ์ |
Oral |
นานาชาติ |
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| 4 |
Preparation of ultrathin-film composite membranes used as nanofiltration materials |
Preparation of ultrathin-film composite membranes used as nanofiltration materials |
Membrane technology is important and widespread in many industries. Nanofiltration process is a highly efficient and useful process for colloid and salt filtering. Therefore, this research studied the synthesis of nanofiltration membrane from ultrathin-film composite membrane to improve the filtering efficiency. The membrane substrate is polyvinylidene fluoride that has hydrophobic property. To enhance hydrophilic property, nanofiltration membrane was modified by coating with tannin and polyamide. Polyamide was prepared by polymerization of 1,3,5-benzenetricarboxylic acid chloride (TMC) and diamine. The type and amount of monomer and condition of polymerization were varied. Then, the surface morphology, functional group and hydrophilic property of nanofiltration membranes were characterized by SEM, FT-IR, contact angle, respectively. The water flux was evaluated. In addition, rejection test for 1000 ppm polyethylene glycol (PEG) with molecular weight of 400 g/mol was performed. The unmodified membrane showed contact angle of 68.25-27.39º. The results showed that the nanofiltration membrane coated with hydrophilic propertyshowed contact angle of 27.75 – 7.69º, water flux of 1.52 (L/m2 hr.) and the highest rejection test of 68.9%. Therefore, the synthesized composite membrane is suitable for further study and development. |
พรพรรณ พึ่งโพธิ์ |
Oral |
นานาชาติ |
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| 5 |
Preparation of zeolite a using silica from rice husk for dye removal |
Preparation of zeolite a using silica from rice husk for dye removal |
Agricultural waste may be disposed by means of burning, which causes pollution and destroys the environment. Some agricultural wastes can produce the silica as a source for zeolite synthesis. In this research, the extraction of silica from rice husk was conducted. Agricultural waste was purified by leaching in HCl and sintering for 3 hours at 700°C. XRF results showed that the obtained ash has high silica SiO2 content. Zeolite A was then synthesized using silica from natural source. The structure of obtained zeolite A was confirmed by XRD and XRF Consequently, the obtained zeolite A was used as an adsorbent for removal of a cationic dye, brilliant green. The amount of adsorbent was varied from 0.10 to 0.75 g with the adsorption time of 1 hour. The optimal adsorbent dosage was 0 5 g with dye removal efficiency of 83 at the dye concentration of 100 ppm. The adsorption time was varied from 30 to 120 minutes. The maximum sorption capacities was 98 at the adsorption time of 2 hours. These results indicate that the synthesized zeolite A can be a potential adsorbent for removing dyes from wastewater. |
สายสมร ลำลอง |
Oral |
นานาชาติ |
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| 6 |
Understanding the structural requirement of rhodanine derivatives as InhA inhibitors based on ligand-based drug design:2D and 3D-QSAR studies |
Understanding the structural requirement of rhodanine derivatives as InhA inhibitors based on ligand-based drug design:2D and 3D-QSAR studies |
Enoyl-ACP reductase (InhA) of Mycobacterium tuberculosis (M. tb) has been shown promising target of anti-tuberculosis drugs. Currently, drug resistance to TB being the leading cause of death. Rhodanine derivatives improved growth-blocking effect on M. tb and low toxicity were attractive for further development. QSAR technique has demonstrated the capability to provide accurate predictions for diverse chemical compounds when trained with molecules of various chemical type. In this study, HQSAR was applied for series of rhodanine derivatives acting as InhA inhibitors. The best HQSAR model was generated using atoms, bond, connections, hydrogen atoms and chirality types as fragment distinction showing crossvalidated q2=0.744, r2=0.814. In addition, CoMFA and CoMSIA models of rhodanine derivatives were set up. The results displayed satisfactory statistical based on CoMFA model with q2=0.675, r2=0.996 and CoMSIA model with q2=0.606, r2=0.983. The CoMFA contour maps reveal that steric and electrostatic interactions corresponding to the InhA inhibition contributing to 55.7%, 44.3%, respectively. Moreover, the CoMSIA contour maps were explained on steric, electrostatic, hydrophobic and hydrogen bond acceptor contributions to 22.6%, 28.7%, 37.7%, 11.1%, respectively. The integrated results of this ligand-based drug design study are fruitful to further design new and more potent rhodanine derivatives as highly potential InhA inhibitors. |
พรพรรณ พึ่งโพธิ์ |
Oral |
นานาชาติ |
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| 7 |
Utilization of fly ash for industrial dyes removal |
Utilization of fly ash for industrial dyes removal |
The aim this work is to investigate potential of fly ash for removal of industrial cationic dye, brilliant green. Fly ash is an abandon waste from power plant. Thailand has expelled fly ash higher than 1.5 million tons each year for almost 2 decades. Fly ash was characterized by X-ray diffraction (XRD), X-ray fluorescence (XRF) and Scanning Electron Microscope (SEM). The results showed that silicon dioxide content was 35.6% of fly ash. An attempt to find an alternative way of fly ash utilization as adsorbent for removal of brilliant green, cationic dye from aqueous solutions was performed. With the initial dye concentration of 300 mg/L, the optimal parameters for adsorption such as adsorbent dosage, contact time, and adsorption isotherm were investigated by batch experiments. The results showed that the optimal fly ash dosage was 4 g/L. The optimal adsorption time was 30 minutes. The regression analysis showed a good fit of the Langmuir isotherm model. It can be concluded that the fly ash can be used as an potential adsorbent without modification for the removal of brilliant green, an industrial dye, from aqueous solutions. |
สายสมร ลำลอง |
Oral |
นานาชาติ |
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| 8 |
Elucidating the binding interactions of benzo[d]isothiazole derivatives as mycobacterium tuberculosis GyrB inhibitors based on molecular dynamics simulations |
Elucidating the binding interactions of benzo[d]isothiazole derivatives as mycobacterium tuberculosis GyrB inhibitors based on molecular dynamics simulations |
The benzo[d]isothiazole derivatives have been developed as Mycobacterium tuberculosis GyrB inhibitor. In the present study the binding mode, binding interactions, decomposition energy and binding energy between benzo[d]isothiazole derivatives and GyrB were determined using molecular dynamics simulations. The results showed good correlation between the MM-GBSA binding energy. The crucial interactions showed cation-pi between benzo[d]isothazole rings with ammonium ion (NH3 + ) of Lys108 residue. 4-Chlorophenyl ring at the R substituent formed hydrophobic interactions with Val49, Val123, Leu135 and Ile171 residues. Van der Waals interactions between benzo[d]isothiazole derivatives and Asn52 and Thr169 residues were found. The high contributions of these interactions were evaluated by their decomposition energy. Therefore, our results obtained aid to better understand the crucial binding characteristics of benzo[d]isothiazole derivatives with GyrB and to gain useful information on how to design novel GyrB inhibitors as potential anti-tuberculosis agents. |
พรพรรณ พึ่งโพธิ์ |
Oral |
นานาชาติ |
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